Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004–2006–2011)

Touboul, Pierre‐Jean; Hennerici, Michael G.; Meairs, Stephen; Adams, Hadie; Amarenco, Pierre; Bornstein, Natan M.; Csiba, László; Desvarieux, Moïse; Ebrahim, Shah; Hernández, R.; Jaff, Michael R.; Kownator, Serge; Naqvi, Tasneem Z.; Prati, Patrizio; Rundek, Tatjana; Sitzer, Matthias; Schminke, Ulf; Tardif, Jean‐Claude; Taylor, Allen J.; Vicaut, Éric; Woo, Kam-Sang

doi:10.1159/000343145

Cited by 1,443 publications

(1,030 citation statements)

References 79 publications

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“…IMT is considered a surrogate marker for atherosclerosis and a strong predictor of future cardiovascular events [29][30][31]. However, many methods are used to measure IMT.…”

Section: Discussionmentioning

confidence: 99%

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

et al. 2016

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PRIMARY ALDOSTERONISM (PA) is characterized by excessive secretion of the mineralocorticoid hormone aldosterone and is frequently caused by an aldosterone-secreting adrenocortical adenoma or adrenal hyperplasia [1,2]. PA is the most frequent form of secondary hypertension and has been estimated to affect 5-15% of hypertensive patients [3][4][5]. Moreover, the prevalence of PA has been found to correlate with the severity of hypertension [6,7], and patients with PA are at higher risk for cardiovascular events than those with essential hypertension [8][9][10] Abstract. Primary aldosteronism (PA) is associated with a higher rate of cardiovascular events than essential hypertension. Although adrenalectomy has been reported to reduce carotid intima-media thickness (IMT) in patients with PA, the effects of the selective aldosterone blocker, eplerenone, on vascular damage in these patients remains unclear. To evaluate the effects of eplerenone on vascular status in PA patients, we sequentially measured carotid IMT (using computer software to calculate an average IMT for accurate and reproducible evaluation) in 22 patients including 8 patients treated by unilateral adrenalectomy and 14 patients treated with eplerenone for 12 months. Patients who underwent adrenalectomy showed significant reductions in aldosterone concentration (from 345 ± 176 pg/mL to 67 ± 34 pg/mL; P<0.01) and IMT (from 0.67 ± 0.07 mm to 0.63 ± 0.09 mm; P<0.05) 6 months after surgery. Patients treated with eplerenone showed significant reductions in IMT from baseline (0.75 ± 0.10 mm) to 6 (0.71 ± 0.11 mm; P<0.05) and 12 (0.65 ± 0.09 mm; P<0.01) months, although plasma aldosterone level increased significantly, from 141 ± 105 pg/mL to 207 ± 98 pg/mL (P<0.05). Eplerenone treatment of patients with PA reduces blood pressure, increases serum potassium level, and improves vascular status. Carotid IMT may be a useful marker for evaluating the effectiveness of eplerenone in patients with PA.

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“…IMT is considered a surrogate marker for atherosclerosis and a strong predictor of future cardiovascular events [29][30][31]. However, many methods are used to measure IMT.…”

Section: Discussionmentioning

confidence: 99%

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

et al. 2016

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“…The underlying cause of these cardiovascular disease subgroups is atherosclerosis, a complex multifactorial disorder of the arteries initiated by endothelial dysfunction, inflammation, and dyslipidemia 2, 3. Subclinical measures of atherosclerosis include common carotid artery intima‐media thickness (CCA‐IMT) and carotid atherosclerotic plaques, both of which have been shown to predict myocardial infarction and stroke 4, 5, 6…”

Section: Introductionmentioning

confidence: 99%

Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women

Blekkenhorst

Bondonno

Lewis

et al. 2018

JAHA

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BackgroundDietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima‐media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA‐IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years).Methods and ResultsTotal vegetable intake was calculated at baseline (1998) using a validated food frequency questionnaire. Vegetable types included cruciferous, allium, yellow/orange/red, leafy green, and legumes. In 2001, CCA‐IMT (n=954) and carotid focal plaque (n=968) were assessed using high‐resolution B‐mode carotid ultrasonography. Mean (SD) total vegetable intake was 199.9 (78.0) g/d. Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean CCA‐IMT (P=0.014) and maximum CCA‐IMT (P=0.004) compared with participants consuming <2 servings of vegetables. For each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA‐IMT (P<0.01) and 0.007 mm (0.8%) lower maximum CCA‐IMT (P<0.01). Other vegetable types were not associated with CCA‐IMT (P>0.05). No associations were observed between vegetables and plaque severity (P>0.05).ConclusionsIncreasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women.Clinical Trial Registration URL: http://www.anzctr.org.au. Unique identifier: ACTRN12615000750583.

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“…To measure the left carotid, the participant turned on to the opposite side, and the process was repeated. Data were interpreted according to the Mannheim Consensus [51]. …”

Section: Methodsmentioning

confidence: 99%

Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

Ali

Soo

Agongo

et al. 2018

Global Health Action

152

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There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continent.

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Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004–2006–2011)

Cited by 1,443 publications

References 79 publications

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women

Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

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