Mannich Bases from 1,2-Diphenylindolizine: Ephedrine and Methamphetamine as Amine Components

Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction

“…Indolizines, which consist of a π-excessive pyrrole and a π-deficient pyridine ring, are known to possess a variety of important biological activities, such as antibacterial, antiviral, anti-inflammatory, central nervous system (CNS) depressant activity, etc. They are also widely employed in the field of materials science such as organic light-emitting devices (OLEDs), biological markers, and dyes .…”

Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis

“…The synthesis of “privileged” structures indolizines and imidazopyridines has received significant attention recently, mainly fueled by their attractive and broad biological properties, such as anti-HIV, anti-inflammatory, and CNS depression agents activities. In addition to the traditional methods such as the Scholtz and the Tschitschibabin reactions, the more efficient catalytic processes have been developed for their preparation, but dominated by transition metal catalysis.…”

TLC Analysis of Mannich Bases Derived from Indolizines

“…It was established in previous work that certain indolizines with dialkylaminomethyl side chains at the C-3 position exhibit pronounced CNS depression (1,2). As part of a continuing exploration of indolizines with potential biological activity, a series of Mannich bases with N-substituted cyclohexylaminomethyl groupings were synthesized using 1,2-diphenylindolizine as the starting compound.…”