Mannich bases of 3H-pyrrolo[3,2-f]quinoline having vasorelaxing activity

Annelated Pyrrolo[1,2-a][1,4]diazepines in Mannich Reaction

“…The diazepines, synthesized using our method (Scheme ), have at least two possible centers that are attractive for iminium ions arisen from formaldehyde and an amine interaction: the pyrrole ring and the aromatic one. Both electron‐rich heterocycles such as pyrroles and activated arenes have been reported to undergo aminoalkylation under Mannich conditions.…”

Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities

“…Quinoline-based heterocycles have attracted much attention from both synthetic chemists and medicinal chemists due to their interesting anticancer, 1 antimalarial, 2 antibacterial, 3 antimycobacterial, 4 anti-inflammatory, 5 antihypertensive, 6 antiviral, 7 and anti-oxidant activities. 8 Several marketed drugs such as quinine and cabozantinib contain the quinoline scaffold.…”

Structural characterisation of some vanillic Mannich bases: Experimental and theoretical study

“…Many alkaloids, nucleotides, steroids, peptides, antibiotics and vitamins [6e10] comprise Mannich base fragments. Bioactivity, such as antioxidative [11], antifungal [12], antiinflammatory [13], antimalarial [14], vasorelaxing [15], antitubercular [16], analgesic [17], anticancer [18e21], etc., is a common feature of this class of compounds. Recently, the details on the synthesis and biological activity of some Mannich bases were reported [22].…”