Mannich Bases: Synthesis, Pharmacological Activity, and Applications: A Review

Abstract

The Mannich reaction is one of the most important types of organic chemistry fundamental reactions. It is a crucial stage in the production of various medicines, natural goods, and industrial chemicals. Chemists' imaginations have always been piqued because of this. In general, the Mannich reactions can be used as part of a tandem reaction sequence to produce complex target molecules in an elegant and often easy manner. The following article examines and summarizes methods for synthesizing Mannich derivatives, in addition to offering a survey of recent advancements in several fields’ applications of the Mannich reaction, such as biological applications, antimicrobial activity, anticancer activity, anti-inflammation and antioxidant activity, antimalarial activity, anti-viral activity, and so on. We also go over how mannich base is used in industry and agriculture.

Synthesis, Characterization, Biological Activity, and Molecular Docking Study of Some New Sulfamethoxazole Derivatives.

“…The Mannich reaction involved the condensation of aldehyde, amine, and compounds that have H-activity. For many years, The Mannich reaction has been an essential method for yielding molecules with desirable pharmacological characteristics 9,10 . The significant applications of these produced compounds have withdrawn researchers' attention accordingly; this led to extending their efforts in doing much research in this field of knowledge 11 .…”

“…Figs. [5][6][7][8][9][10][11][12][13][14][15] show the bonding of some compounds in proteins. Table 5 shows various interactions involved between receptors and compounds, types of bonding, and bond length.…”

Investigations of Electronic, Structural, and In Silico Anticancer Potential of Persuasive Phytoestrogenic Isoflavene-Based Mannich Bases

“…Secondly, aminomethylation of drugs also improves their bioavailability. The Mannich bases potentially help increase medication distribution in humans [18][19][20]. The drug's hydrophilic characteristics might be improved by introducing a polar molecule into the parent structure through the Mannich reaction.…”