Mannich reaction of secondary amines, aldehydes and alkynes in water using Cu/C nanoparticles as a heterogeneous catalyst

Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base

“…Step 1: Molecular sieves, Toluene, 0˚C, 10 h, Step 2: TOSMIC/K 2 CO 3 , 0˚C, 16 h, Step 3: 5% Pd(OH) 2 , H 2 , 70 Psi, 3 h, Step 4: 2-bromo-1,1-dimethoxyethane, K 2 CO 3 /DMF, 5 h, Step 5: thiazolidine-2,4-dione, Piperdine, 90˚C, 6 h, Step 6: Paraformaldehyde/2˚ Amine, Sc(OTf) 3 , EtOH, 90˚C, 8 h.…”

“…The Reaction mixture was poured in ice cold water (200 mL) and stirred for 20 min. The reaction mixture was acidified with aqNaHSO 3 Step 6 Table 1. Step 7: General procedure for -3-…”

“…The reaction mixture was poured in aq sat NaHCO 3 and stirred for 15 min. The a.q layer was extracted with 10% MeOH-CHCl 3 (3 × 25 ml) and dried over anhydrous Na 2 SO 4 , filtered and evaporated under vacuum to give crude product.…”

Simple, Efficient, and Applicable Route for Synthesis of 2-Aryl(Heteroaryl)-Benzimidazoles at Room Temperature Using Copper Nanoparticles on Activated Carbon as a Reusable Heterogeneous Catalyst

“…Synthetic organic routes followed by using heterogeneous catalysts have advantages over their counterparts in which, used-catalyst can be easily recycled [21]. As a part of our continued efforts to utilize heterogeneous catalysts for developing organic reactions [37][38][39][40][41][42][43][44][45][46][47][48][49][50], herein we report on a new and reused catalyst system based on copper on charcoal (Cu/C). This heterogeneous catalyst system exhibits an excellent catalytic performance for the construction of the 2-arylbenzimidazoles framework.…”

NiO nanoparticles catalyzed three component coupling reaction of aldehyde, amine and terminal alkynes

“…These catalysts are expensive and suffer from one or more drawbacks such as longer reaction time and difficulty in recovery of the catalyst. The heterogeneous catalysts have numerous advantages over the homogeneous catalysts because recyclability of catalysts such as mesoporous copper silicate [28], mesoporous copper-aluminum based nanocomposites [29], Ag nanoparticles supported on nickel metal organic framework [30], Ni-Y-Zeolite [31], Cu/C nanoparticles [32], Co 3 O 4 nanoparticles [33], copper-zeolites [34] nanocrystalline copper oxide [35], gold nanoparticles [36,37] has been reported for the synthesis of three component coupling reaction of aldehyde, amine and terminal alkynes.…”