Mannitol, furosemide, and dopamine infusion in postoperative renal failure complicating cardiac surgery

2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery

“…259,265 In an analysis of 9476 patients hospitalized with an acute coronary syndrome (ACS) who underwent CABG during the index hospitalization, 1344 (14%) were STEMI patients with shock or intra-aortic balloon placement preoperatively. 264 These individuals had a mortality rate of 4% when CABG was performed on the third hospital day, which was lower than the mortality rates reported when CABG was performed earlier or later during the hospitalization. 264 In studies in which the data from STEMI patients were analyzed separately with regard to the optimal timing of CABG, however, the results appear to be different.…”

“…264 These individuals had a mortality rate of 4% when CABG was performed on the third hospital day, which was lower than the mortality rates reported when CABG was performed earlier or later during the hospitalization. 264 In studies in which the data from STEMI patients were analyzed separately with regard to the optimal timing of CABG, however, the results appear to be different. In 1 analysis of 44 365 patients who underwent CABG after MI (22 984 with STEMI; 21 381 with NSTEMI), the inhospital mortality rate was similar in the 2 groups undergoing CABG Ͻ6 hours after diagnosis (12.5% and 11.5%, respectively), but it was higher in STEMI patients than in NSTEMI patients when CABG was performed 6 to 23 hours after diagnosis (13.6% versus 6.2%; Pϭ0.006).…”

Effects of Mannitol and Dopamine on Renal Function in Coronary Artery Bypass Surgery

“…(29) , böbrek kan akımı ve natriürezi-si arttırmaya yarayan ajanlar ile akut böbrek hasarını önlemek için çeşitli yaklaşım şekillerini denemişler-dir (28) . Postoperatif oligurik ve anurik böbrek yetersizliği olan yüz hastaya, randomize olarak loop diü-retikleri aralıklı dozlarda veya mannitol, furosemide ve dopamin (2 μg kg -1 dk -1…”

“…İnterlobüler arterler, afferent ve effrent glomerüler arterioller üzerinde vasodilatasyon yaparak, renal kan akımını ve glomerü-ler filtrasyonu arttırır. Dopamin kalp debisini arttırır ve renal perfüzyonu korur ve renal metabolizmayı azaltır ve diüreze yol açar (3) .…”

Comparison of Early Results Between on-Pump and Off-Pump Cabg in Patients With Preoperative Mild to Moderate Renal Impairment.

“…Drugs that Block Inflammation Inflammation is well documented to occur during CPB and has a prominent role in the pathogenesis of ARF and CPB. [30] It thus is an attractive therapeutic target. Pentoxifylline a phosphodiesterase inhibitor, blocks the activation of neutrophils by TNF-α and IL-1 and TNF-α release by inflammatory cells.…”