Mannose-Anchored Nano-Selenium Loaded Nanostructured Lipid Carriers of Etravirine for Delivery to HIV Reservoirs

Rojekar, Satish; Abadi, Leila Fotooh; Pai, Rohan; Prajapati, Mahendra; Kulkarni, Smita; Vavia, Pradeep R.

doi:10.1208/s12249-022-02377-8

Cited by 16 publications

(5 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Methodsmentioning

confidence: 99%

“…The combination of delivering drugs via mannosylated nanostructured lipid carriers, coupled with the inclusion of Nano-Selenium, emerges as a promising and efficient approach for drug delivery to HIV reservoirs while concurrently addressing oxidative stress induced by prolonged therapies. 9 In 2021, Faheem et al also conducted studies about anti-viral drug structural modification. Chitosan (CS) and Starch (SR), which act as hydrophobic drug carriers, were copolymerized as biodegradable nanohydrogels and functionalized with phthalic anhydride and hexamethylenetetramine, respectively, using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide catalyzed coupling.…”

Section: Current Development Of Antiviral Drugs Nanoparticle Drug Del...mentioning

confidence: 99%

“…4 Among the most explored methodologies are nanoparticle drug delivery systems including nanostructured lipid carriers, solid lipid nanoparticle, solid lipid nanoparticle, and hybrid nanoparticle. [5][6][7][8][9] Also, others type of modification like liposomes, cocrystals, solid dispersions, salt formation, and structural modification. Numerous studies pertaining to the development of antiviral drugs have been published.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Revolutionizing Antiviral Therapeutics: Unveiling Innovative Approaches for Enhanced Drug Efficacy

Megantara,

Rusdin,

Budiman

et al. 2024

IJN

View full text Add to dashboard Cite

Since the beginning of the coronavirus pandemic in late 2019, viral infections have become one of the top three causes of mortality worldwide. Immunization and the use of immunomodulatory drugs are effective ways to prevent and treat viral infections. However, the primary therapy for managing viral infections remains antiviral and antiretroviral medication. Unfortunately, these drugs are often limited by physicochemical constraints such as low target selectivity and poor aqueous solubility. Although several modifications have been made to enhance the physicochemical characteristics and efficacy of these drugs, there are few published studies that summarize and compare these modifications. Our review systematically synthesized and discussed antiviral drug modification reports from publications indexed in Scopus, PubMed, and Google Scholar databases. We examined various approaches that were investigated to address physicochemical issues and increase activity, including liposomes, cocrystals, solid dispersions, salt modifications, and nanoparticle drug delivery systems. We were impressed by how well each strategy addressed physicochemical issues and improved antiviral activity. In conclusion, these modifications represent a promising way to improve the physicochemical characteristics, functionality, and effectiveness of antivirals in clinical therapy.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Current Development Of Antiviral Drugs Nanoparticle Drug Del...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Revolutionizing Antiviral Therapeutics: Unveiling Innovative Approaches for Enhanced Drug Efficacy

Megantara,

Rusdin,

Budiman

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

“…On days 14, 21 and 28 of the post-traumatic period, the subjects were humanely euthanized using halothane and their brains were removed. The forebrain was extracted for spectral analysis through the use of energy-dispersive X-ray fluorescence analysis (EDRFA) on the EXPERT 3 XL analyser [12].…”

Section: Methodsmentioning

confidence: 99%

Changes of Biometals in the Rat Forebrain in the Early Period of Blast-Induced Traumatic Brain Injury

Kozlova

2023

Act. Probl. of the Modern Med.

View full text Add to dashboard Cite

Blast-induced traumatic brain injury is a complex of impairments caused by the rapid transfer of energy from the explosion to the brain. The main pathogenic factor is the blast wave, which leads to primary diffuse damage. The question of the biometals participation in the pathogenesis of secondary damage in various structures of the brain, in particular in the forebrain in the early period of mild blast-induced traumatic brain injury, is attracting considerable interest at present. The experiment carried out on 36 sexually mature male Wistar rats weighing 220-270 g in the laboratory of the Department of Pathological Anatomy, Forensic Medicine and Pathological Physiology of the Dnipro State Medical University in compliance with current legislation on ethical treatment of animals. Rats were kept in standard vivarium conditions and were randomly divided into 2 groups: experimental (subjected to anaesthesia and exposure to a baroacoustic wave of 26-36 kPa) and intact groups. On the 14th, 21st, and 28th days of the post-traumatic period, the animals were euthanized with halothane followed by removal of the brain and separation of the forebrain. Spectral research was carried out using energy-dispersive X-ray fluorescence analysis. The analysis of the results showed an intragroup increase in the level of Fe by 3% and Cu by 36% and a decrease in Zn by 36%, but all these biometals and their ratios (Cu/Fe, Cu/Zn, Zn/Fe) were more in the experimental rats. We consider that these biometals lead to oxidative stress, damage to the neurons and mitochondria membranes, development of energy deficit, excitation of neurons, disruption of axonal conduction and synaptic transmission. The obtained data can be suggested as factors of secondary damage and used as diagnostic and prognostic markers of this injury type; they can also be used as the foundation for developing pathogenetically validated neuroprotection.

show abstract

“…22,23 Vavia et al have prepared lipid nanoparticles containing antiretroviral drugs and nanoselenium to act more efficiently against HIV infection. [24][25][26][27] These nanoparticles showed a wide range of sizes and polydisperse nature, which allows them to simultaneously target multiple HIV reservoirs. The formulation was found to exhibit high cellular uptake and efficacy against HIV, further enhancing its potential in multi-reservoir targeting.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible metal–organic frameworks as promising platforms to eradicate HIV reservoirs ex vivo in people living with HIV

Lebrón,

Ostos,

Martínez-Santa

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Mannose-Anchored Nano-Selenium Loaded Nanostructured Lipid Carriers of Etravirine for Delivery to HIV Reservoirs

Cited by 16 publications

References 80 publications

Revolutionizing Antiviral Therapeutics: Unveiling Innovative Approaches for Enhanced Drug Efficacy

Revolutionizing Antiviral Therapeutics: Unveiling Innovative Approaches for Enhanced Drug Efficacy

Changes of Biometals in the Rat Forebrain in the Early Period of Blast-Induced Traumatic Brain Injury

Biocompatible metal–organic frameworks as promising platforms to eradicate HIV reservoirs ex vivo in people living with HIV

Contact Info

Product

Resources

About