2012
DOI: 10.1186/ar4057
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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

Abstract: IntroductionA role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE.MethodsIn a case control study SLE patients (93 females) and 67 age, sex, ethnicity matched healthy controls were enrolled. Plasma MBL levels were quantified by enzyme linked immunosorbent assay (ELISA). Clinical, serological … Show more

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Cited by 50 publications
(38 citation statements)
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“…In order to improve the outcome of LN, it is crucial to identify biomarkers that can reflect early renal involvement in SLE. During the past few years, several novel biomarkers have been identified as promising candidates for LN [13][14][15][16][17][27][28][29][30][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…In order to improve the outcome of LN, it is crucial to identify biomarkers that can reflect early renal involvement in SLE. During the past few years, several novel biomarkers have been identified as promising candidates for LN [13][14][15][16][17][27][28][29][30][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…Many PRRs have been reported in several chronic inflammatory diseases. Plasma mannose-binding lectin was significantly high in patients with systemic lupus erythematosus (SLE) compared with healthy control (HC), and correlated with disease activity markers [ 15 ]. The level of CD209 was higher in psoriasis vulgaris lesions than normal tissues [ 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…Mice deficient for C1q, the recognition protein of the classical complement pathway, are predisposed to SLE-like diseases [ 10 ] and human studies report that hereditary homozygous deficiencies of C1q are strongly associated with susceptibility to SLE, with a defect in apoptotic cells uptake by macrophages in SLE patients [ 11 ]. Recent reports suggest a role for mannan-binding lectin (MBL), a recognition protein of the lectin complement pathway, in the pathogenesis of SLE [ 12 ]. Indeed, gene polymorphisms leading to reduced levels of serum MBL were found associated with a predisposition to SLE [ 13 ].…”
Section: Introductionmentioning
confidence: 99%