Mannose-binding lectin codon 54 gene polymorphism in relation to risk of nosocomial invasive fungal infection in preterm neonates in the neonatal intensive care unit

Aydemir, Cumhur; Önay, Hüseyin; Oğuz, Şerife Suna; Özdemir, Taha Reşi̇d; Erdeve, Ömer; Özkınay, Ferda; Dilmen, Uğur

doi:10.3109/14767058.2010.536865

Cited by 15 publications

(16 citation statements)

References 21 publications

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“…21 Negative results were also found by Koroglu et al 24 on 99 premature neonates, in which sepsis was defined by microbiological identification of pathogens in blood cultures. However, when clinical sepsis was the outcome, the frequency of sepsis was higher in the group of infants with MBL gene polymorphism than among infants with wildtype MBL genotype (61.2 versus 31.7%, respectively, P = 0.008).…”

Section: Mannose-binding Lectin Polymorphismmentioning

confidence: 70%

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Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

et al. 2013

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CONTEXT AND OBJECTIVE: Neonatal sepsis is associated with premature birth and maternal infection. Large-scale studies seek to define markers that identify neonates at risk of developing sepsis. Here, we examine whether the scientific evidence supports systematic use of polymorphism genotyping in cytokine and innate immunity genes, to identify neonates at increased risk of sepsis. DESIGN AND SETTING: Narrative literature review conducted at Fernandes Figueira Institute, Brazil. METHODS:The literature was searched in PubMed, Embase (Excerpta Medica Database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Cochrane Library. From > 400,000 references, 548 were retrieved based on inclusion/exclusion criteria; 22 were selected for detailed analysis after quality assessment. RESULTS:The studies retrieved addressed the impact of gene polymorphisms relating to immune mechanisms (most often TNF-a, LT-a, IL-6, IL-1β, IL-1ra, L-selectin, CD14 and MBL) or inflammatory mechanisms (ACE and angiotensin II receptors; secretory PLA2; and hemostatic factors). Despite initial reports suggesting positive associations between specific polymorphisms and increased risk of sepsis, the accumulated evidence has not confirmed that any of them have predictive power to justify systematic genotyping. CONCLUSIONS: Sepsis prediction through systematic genotyping needs to be reevaluated, based on studies that demonstrate the functional impact of gene polymorphisms and epidemiological differences among ethnically distinct populations. RESUMO CONTEXTO E OBJETIVO:A sepse neonatal está associada ao parto prematuro e à infecção materna. Estudos em grande escala buscam marcadores que identifiquem neonatos em risco de desenvolver sepse. Examinamos aqui se a evidência científica apoia o uso sistemático de genotipagem dos polimorfismos em genes de citocinas e imunidade inata, para identificar neonatos com risco elevado de sepse. TIPO DE ESTUDO E LOCAL:Revisão narrativa da literatura, Instituto Fernandes Figueira, Brasil. MÉTODOS: Busca online da literatura foi feita no PubMed, Embase (Excerpta Medica Database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) e Cochrane Library. De mais de 400.000 referências, 548 foram recuperadas com base nos critérios de inclusão/exclusão, e 22, selecionadas para análise detalhada após verificação da qualidade. RESULTADOS: Recuperamos estudos de impacto dos polimorfismos em genes relacionados com mecanismos imunes (mais frequentemente, TNF-a, LT-a, IL-6, IL-1β, IL-1ra, L-selectin, CD14, e MBL) ou inflamató-rios (ACE e receptores de angiotensina II; PLA2 secretória; fatores hemostáticos). Contrariando estudos que inicialmente sugeriram associação positiva entre polimorfismos específicos e risco aumentado de sepse, a evidência acumulada não confirmou, para qualquer deles, valor preditivo que justifique genotipagem sistemática para orientar antibioticoterapia. CONCLUSÕES: A...

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Section: Mannose-binding Lectin Polymorphismmentioning

confidence: 70%

“…Aydemir et al 21 Härtel et al 9 Abu-Maziad et al 22 Auriti et al 23 Koroglu et al 24 Spiegler et al 25 Abdel-Hady et al 26 Bertalan et al 27 Reiman et al 28 Dzwonek et al 29 van Der Zwet et al 30 Schueller et al 31 Derzbach et al 32 Härtel et al 33 Baier et al 34 Göpel et al…”

Section: Questions (Q)unclassified

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

et al. 2013

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“…Hashimoto et al (25) found no significant difference between patient and control groups in their study investigating the role of MBL2 codon 54 polymorphisms on the predisposition of patients with atopic dermatitis to cutaneous infections, such as the herpes virus and Staphylococcus aureus. The MBL2 gene codon 54 polymorphism was reported to exhibit no difference in preterm neonates with nosocomial fungal infection and the control group (26). Rantala et al (27) reported that MBL2 promoter site polymorphism and low serum levels were associated with increased Chlamydia pneumoniae antibodies.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Mannose-binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens Johnson Syndrome and Stevens Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome

Karkucak¹,

Bülbül²,

Turan³

et al. 2012

Balkan Med J

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Objective: Monnose-Binding lectin (MBL) appears to play an important role in the immune system. The genetic polymorphisms in the MBL2 gene can result in a reduction of serum levels, leading to a predisposition to recurrent infection. The aim of this study is to investigate the influence of a polymorphism in codon 54 of the MBL2 gene on the susceptibility to Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome (EM, SJS and SJS/TEN overlap syndrome).Material and Methods: Our study included 64 patients who were clinically and/or histopathologically diagnosed with EM, SJS, and SJS/TEN overlap syndrome and 66 healthy control subjects who were genotyped for the MBL2 gene codon 54 polymorphism using the PCR-RFLP method. For all statistical analyses, the level of significance was set at p<0.05. Results:The prevalence of the B allele was 18% in the EM, SJS and SJS/TEN patient groups and 13% in the control group. No significant differences in allele frequencies of any polymorphism were observed between the patient and control groups, although the B allele was more frequent in the patient groups (p=0.328). Conclusion:Our results provide no evidence of a relationship between MBL2 gene codon 54 polymorphism and the susceptibility to EM, SJS and SJS/ TEN overlap syndrome. However, these findings should be confirmed in studies with a larger sample size.

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“…The persistence of infection was demonstrated to correlate with decreased IL-12 and increased IL-10 production induced by the presence of Candida , which may result in inhibition of the T H 1 response that is known to be crucial for anti- Candida systemic immunity [66,67]. In agreement with this, a decreased production of T H 2 cytokines such as IL-4 owing to genetic variation in the IL4 gene also leads to protective effects [68,69]. …”

Section: Common Genetic Variation and Susceptibility To Fungal Infectmentioning

confidence: 98%

“…Indeed, genetic associations of MBL deficiency with infection risk have been observed in cohorts of patients with candidemia, abdominal infections and RVVC [48–50,68]. …”

Section: Common Genetic Variation and Susceptibility To Fungal Infectmentioning

confidence: 99%

Medical mycology and fungal immunology: new research perspectives addressing a major world health challenge

Gow

Netea

2016

Phil. Trans. R. Soc. B

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Fungi cause more than a billion skin infections, more than 100 million mucosal infections, 10 million serious allergies and more than a million deaths each year. Global mortality owing to fungal infections is greater than for malaria and breast cancer and is equivalent to that owing to tuberculosis (TB) and HIV. These statistics evidence fungal infections as a major threat to human health and a major burden to healthcare budgets worldwide. Those patients who are at greatest risk of life-threatening fungal infections include those who have weakened immunity or have suffered trauma or other predisposing infections such as HIV. To address these global threats to human health, more research is urgently needed to understand the immunopathology of fungal disease and human disease susceptibility in order to augment the advances being made in fungal diagnostics and drug development. Here, we highlight some recent advances in basic research in medical mycology and fungal immunology that are beginning to inform clinical decisions and options for personalized medicine, vaccine development and adjunct immunotherapies.This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.

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Mannose-binding lectin codon 54 gene polymorphism in relation to risk of nosocomial invasive fungal infection in preterm neonates in the neonatal intensive care unit

Abstract: In our study, no relationship was found between MBL codon 54 gene polymorphism and the risk of nosocomial invasive fungal infection in preterm neonates in NICU.

Cited by 15 publications

References 21 publications

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

Investigation of Mannose-binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens Johnson Syndrome and Stevens Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome

Medical mycology and fungal immunology: new research perspectives addressing a major world health challenge

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