Mannose-binding lectin gene polymorphisms and hepatitis B virus infection in Vietnamese patients

Song, Lê Hữu; Binh, Vu Q.; Duy, Dinh N.; Jüliger, Simone; Bock, C.‐Thomas; Luty, Adrian J. F.; Kremsner, Peter G.; Kun, Jürgen F. J.

doi:10.1016/s0027-5107(02)00284-1

Cited by 47 publications

(45 citation statements)

References 28 publications

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“…22,23,27 Another report suggested that allele B (codon 54) was over-represented in Vietnamese patients with acute hepatitis B when compared with healthy controls. 35 However, we did not find any increase in low MBL genotype frequency in spontaneously recovered individuals or nonprogressed HBsAg carriers compared with naïve controls to implicate low MBL levels as a susceptibility factor in acute HBV infection. In the Vietnamese study, the number of patients with acute HBV infection was relatively small at 31, and the healthy controls, which were defined as HBsAg negative, may have included both naïve and spontaneously recovered individuals.…”

Section: Discussioncontrasting

confidence: 75%

Mannose-Binding Lectin in Chronic Hepatitis B Virus Infection *

Chong

et al. 2005

Hepatology

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Mannose binding lectin (MBL) is a pattern-recognition molecule of the innate immune system. The roles of MBL and its gene (mbl2) polymorphisms, ؊221X/Y and codon 54A/B, in hepatitis B virus (HBV) infection were investigated in this study. We recruited 320 nonprogressed hepatitis B surface antigen (HBsAg) carriers; 199 progressed HBsAg carriers with hepatocellular carcinoma or cirrhosis; 87 spontaneously recovered individuals who were HBsAg negative and anti-HBs and anti HBc positive; and 484 controls who were naïve to HBV. There was no significant difference between nonprogressed carriers, spontaneously recovered individuals, and controls in terms of serum MBL levels and mbl2 polymorphisms distributions. However, the low MBL genotypes had a dose-dependent correlation with the cirrhosis and hepatocellular carcinoma in progressed carriers with odds ratios of 1.36 and 3.21 for the low and extremely low MBL genotypes, respectively (P ‫؍‬ .01). The lowexpression promoter haplotype XA (OR ‫؍‬ 1.97) and the mutant haplotype YB (OR ‫؍‬ 1.90) were also associated with the cirrhosis and hepatocellular carcinoma (P ‫؍‬ .002). As expected, the lower serum MBL levels in progressed carriers as compared with nonprogressed carriers were due to an overrepresentation of low and extremely low MBL genotypes. Moreover, MBL could bind HBsAg in a dose-and calcium-dependent and mannan-inhibitable manner in vitro, suggesting that binding occurs via the carbohydrate recognition domains. This binding also enhanced C4 deposition. In conclusion, these results suggest that low MBL genotypes associate with the occurrence of cirrhosis and hepatocellular carcinoma in progressed HBsAg carriers, and MBL can bind HBsAg. (HEPATOLOGY 2005;42:1037-1045

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Section: Discussioncontrasting

confidence: 75%

Mannose-Binding Lectin in Chronic Hepatitis B Virus Infection *

Chong

et al. 2005

Hepatology

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“…A few other studies have examined mbl2 with respect to recovery from HBV infection, but the data are inconsistent (1,13,26,31). In the largest of these studies, investigators genotyped the codon 52, 54, and 57 SNPs in 180 Gambians with persistent HBV infections and 157 who had recovered from HBV infections (1).…”

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confidence: 99%

Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection

Thio¹,

Mosbruger²,

Astemborski³

et al. 2005

J Virol

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Mannose binding lectin (MBL) is a central component of the innate immune response and thus may be important for determining hepatitis B virus (HBV) persistence. Since single-nucleotide polymorphisms (SNPs)in the gene encoding MBL (mbl2) alter the level of functional MBL, we hypothesized that mbl2 genotypes are a determinant of HBV persistence or recovery from viral infection. We tested this hypothesis by using a nested case control design with 189 persons with HBV persistence matched to 338 individuals who had naturally recovered from HBV infection. We determined genotypes of two promoter and three exon 1 SNPs in mbl2 and grouped these genotypes according to the amount of functional MBL production. We found that the promoter SNP ؊221C, which leads to deficient MBL production, was more common in those subjects with viral persistence (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.01 to 1.89; P ‫؍‬ 0.04). Those subjects homozygous for the combination of promoter and exon 1 genotypes associated with the highest amount of functional MBL had significantly increased odds of recovery from infection (OR, 0.55; 95% CI, 0.37 to 0.84; P ‫؍‬ 0.005). Conversely, those homozygous for the combination of promoter and exon 1 genotypes which produce the lowest amount of functional MBL were more likely to have viral persistence (OR, 1.76; 95% CI, 1.02 to 3.01; P ‫؍‬ 0.04). These data are consistent with the hypothesis that functional MBL plays a central role in the pathogenesis of acute hepatitis B.Chronic hepatitis B infection affects 400 million people and is the most common cause of cirrhosis and hepatocellular carcinoma worldwide. Although most adults recover from acute hepatitis B virus (HBV) infection, it is not fully understood why some develop chronic hepatitis B. The strength and breadth of the host immune response are important (3, 30), and recent data from chimpanzees and transgenic mice suggest that differences in innate immunity affect recovery from HBV infection (11,16).Mannose binding lectin (MBL) plays a central role in the innate immune response (32). mbl2, which encodes MBL, is located on chromosome 10 and consists of four exons (Fig. 1). Several single-nucleotide polymorphisms (SNPs) in the gene's promoter and in exon 1 that ultimately reduce the level of functional MBL have been described (8). Reduced MBL concentrations have been linked with diminished responses to several infectious diseases, including human immunodeficiency virus (HIV) infection and recurrent infections, and higher levels have been linked with inflammatory outcomes such as vascular complications of diabetes mellitus (5, 12, 24, 29). Although one exon 1 SNP has been associated with HBV persistence (31), this gene and its functionally different haplotypes have not been comprehensively examined in persons infected with HBV.We hypothesized that the mbl2 SNPs that reduce functional MBL levels would be found more often in persons with HBV persistence and vice versa. To test this hypothesis, we determined genotypes of the promoter SNPs at Ϫ5...

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“…Human MBL is an acute phase protein, and its concentration in blood increases after the acute phase reaction of viral infection (4). A preliminary study by Hakozaki et al (6) revealed that serum MBL levels in patients with acute viral hepatitis were significantly higher than those in controls.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of studies revealed a correlation between MBL polymorphisms that confer low levels of MBL and poor prognoses such as viral persistence (9), disease progression (4,5,10), HBV acquisition (4) and survival in case of fulminant hepatic failure (6). However, some studies did not show any correlation between MBL polymorphisms and the prognosis of HBV infection (11) (as reviewed by Brown et al [3]).…”

Section: Discussionmentioning

confidence: 99%

Potential Role of Mannose-Binding Lectin in Intrauterine Transmission of Hepatitis B Virus

Zhou

Wang

et al. 2013

Jpn J Infect Dis

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SUMMARY: Intrauterine transmission of hepatitis B virus (HBV) is the main cause of the high prevalence of HBV in endemic areas; however, the mechanisms underlying intrauterine transmission of HBV remain unknown. To explore the role of mannose-binding lectin (MBL), a pattern recognition molecule of the innate immune system, in intrauterine transmission of HBV, we determined MBL levels using an enzyme-linked immunosorbent assay (ELISA) in cord serum of 7 intrauterine-infected neonates and 30 non-infected neonates born to HBV-positive mothers, and 30 control neonates born to HBV-negative mothers. We observed significant differences in cord serum MBL levels among the three groups ( P º 0.001). Non-infected neonates had significantly higher MBL levels than controls (P º 0.001), and intrauterine-infected neonates had significantly lower serum MBL levels than non-infected neonates ( P º 0.001). However, serum MBL levels were not significantly different between intrauterine-infected neonates and controls ( P ＝ 0.800). Our results indicate that maternal HBV infection induces an increase in fetal MBL levels and the absence of this increase is possibly associated with intrauterine transmission of HBV, suggesting that MBL plays a role in intrauterine transmission of HBV.

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Mannose-binding lectin gene polymorphisms and hepatitis B virus infection in Vietnamese patients

Cited by 47 publications

References 28 publications

Mannose-Binding Lectin in Chronic Hepatitis B Virus Infection *

Mannose-Binding Lectin in Chronic Hepatitis B Virus Infection *

Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection

Potential Role of Mannose-Binding Lectin in Intrauterine Transmission of Hepatitis B Virus

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