Mannose-Binding Lectin Genotypes and Susceptibility to Epstein-Barr Virus Infection in Infancy

Friborg, Jeppe; Jarrett, Ruth F.; Koch, Anders; Garred, Peter; Freeland, June; Andersen, Andreas; Melbye, Mads

doi:10.1128/cvi.00527-09

Cited by 15 publications

(14 citation statements)

References 27 publications

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“…In conclusion, consistent with findings from other viral infections (4,6,8,10,12,(24)(25)(26), MBL2 polymorphisms known to lead to MBL deficiencies were associated with higher TTV VLs than was wild-type MBL2, supporting the view that innate immunity efficiency contributes to determining the TTV VL size. The increase was modest but might have been greater had we examined subjects earlier in infancy, when the role of MBL in antimicrobial resistance is most important (5,28).…”

supporting

confidence: 78%

“…MBL, encoded by gene MBL2 on chromosome 10, is a pattern recognition protein that exerts its protective action by activating the complement cascade through an antibody-independent pathway triggered by its binding to pathogen surfaces and other mechanisms (13). MBL is probably most important in antibacterial defenses (14) but also plays a significant role against viruses; indeed, MBL2 polymorphisms known to lead to lower-than-normal blood concentrations of functional MBL have been linked with an increased susceptibility to several enveloped and nonenveloped viruses (3,4,6,8,10,12,24,25,26). Furthermore, because the airways are colonized by TTV early in life and may represent a port of body entry (18), we conducted the investigation with patients being evaluated to confirm or exclude the presence of primary ciliary dyskinesia (PCD).…”

mentioning

confidence: 99%

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Torque Teno Virus Viremia Load Size in Patients with Selected Congenital Defects of Innate Immunity

Maggi

Pifferi

Michelucci³

et al. 2011

Clin. Vaccine Immunol.

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supporting

confidence: 78%

mentioning

confidence: 99%

Torque Teno Virus Viremia Load Size in Patients with Selected Congenital Defects of Innate Immunity

Maggi

Pifferi

Michelucci³

et al. 2011

Clin. Vaccine Immunol.

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“…In Asia EBV seroprevalence rapidly increased with age, exceeding 80% by age 5, and 90% by 7-8 years [19,21,36,47]. In contrast, studies in Europe and North America showed a more gradual increase in seroprevalence which did not exceed 90% until age 22 [23,25,28,33,38,43,49,53,79,83]. Studies which used validated, commercially available tests for EBV antigens were more likely to show increases in seroprevalence with age than studies which used in-house tests or did not reported which test they used; these studies also tended to be larger and representative of the underlying population (Table S1 in the Online Supplementary Document).…”

Section: Age and Ebv Seroprevalencementioning

confidence: 94%

“…The majority of studies (19/36) reported no association between sex and EBV serostatus (Table 1) [8,17,19,20,23,29,42,43,[54][55][56]60,61,63,[68][69][70][71][72]. Studies which reported associations [18,22,26,30,32,34,[49][50][51]57,59,62,[64][65][66][67] were evenly split in their findings, with no discernible differences according to study type, population or location, although they were generally small and lacking in power; 9/15 had ≤75 participants.…”

Section: Other Sociodemographic Factors and Ebv Seroprevalencementioning

confidence: 99%

Predictors of Epstein-Barr virus serostatus and implications for vaccine policy: A systematic review of the literature

Winter

Jackson

Lewis

et al. 2020

Journal of Global Health

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Background Epstein-Barr virus (EBV) is an important human pathogen; it infects >90% people globally and is linked to infectious mononucleosis and several types of cancer. Vaccines against EBV are in development. In this study we present the first systematic review of the literature on risk factors for EBV infection, and discuss how they differ between settings, in order to improve our understanding of EBV epidemiology and aid the design of effective vaccination strategies.Methods MEDLINE, Embase, and Web of Science were searched on 6 th March 2017 for observational studies of risk factors for EBV infection. Studies were excluded if they were published before 2008 to ensure relevance to the modern day, given the importance of influencing future vaccination policies. There were no language restrictions. After title, abstract and full text screening, followed by checking the reference lists of included studies to identify further studies, data were extracted into standardised spreadsheets and quality assessed. A narrative synthesis was undertaken.Results Seventy-seven papers met our inclusion criteria, including data from 31 countries. There was consistent evidence that EBV seroprevalence was associated with age, increasing throughout childhood and adolescence and remaining constant thereafter. EBV was generally acquired at younger ages in Asia than Europe/North America. There was also compelling evidence for an association between cytomegalovirus infection and EBV. Additional factors associated with EBV seroprevalence, albeit with less consistent evidence, included ethnicity, socioeconomic status, other chronic viral infections, and genetic variants of HLA and immune response genes. ConclusionsOur study is the first systematic review to draw together the global literature on the risk factors for EBV infection and includes an evaluation of the quality of the published evidence. Across the literature, the factors examined are diverse. In Asia, early vaccination of infants would be required to prevent EBV infection. In contrast, in Western countries a vaccine could be deployed later, particularly if it has only a short duration of protection and the intention was to protect against infectious mononucleosis. There is a lack of high-quality data on the prevalence and age of EBV infection outside of Europe, North America and South-East Asia, which are essential for informing effective vaccination policies in these settings.

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“…This project, a cooperation between Greenland and Denmark, addressed the burden of infectious diseases in Greenland by establishing research programs to evaluate long-term consequences of certain infectious diseases, to evaluate the use of routine surveillance data, to initiate intervention trials in order to prevent infectious diseases, to seek implementation of results in the Greenland health system and to establish cooperation with public health and research organizations in other countries. Specific studies under this project included a validation of the Greenlandic inpatient register, the initiation of tuberculosis studies (47–52), an evaluation of the distribution of bacterial pathogens causing invasive disease (8,53,54), a study of the long-term consequences of hepatitis B (27–30,55), a study of the association between Epstein Barr virus and various cancers (56,57), a study of HIV drug resistance (58,59), a study of HIV and living conditions (60), a study on gene mutations and hearing (61), longitudinal studies on chronic otitis media (62,63), a study of the first case of Q fever endocarditis in Arctic Areas (64) and a study of the aetiology of viral respiratory pathogens among Greenlandic children.…”

Section: Researchmentioning

confidence: 99%

The Arctic Human Health Initiative: a legacy of the International Polar Year 2007–2009

Parkinson

2013

International Journal of Circumpolar Health

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BackgroundThe International Polar Year (IPY) 2007–2008 represented a unique opportunity to further stimulate cooperation and coordination on Arctic health research and increase the awareness and visibility of Arctic regions. The Arctic Human Health Initiative (AHHI) was a US-led Arctic Council IPY coordinating project that aimed to build and expand on existing International Union for Circumpolar Health (IUCH) and Arctic Council human health interests. The project aimed to link researchers with potential international collaborators and to serve as a focal point for human health research, education, outreach and communication activities during the IPY. The progress of projects conducted as part of this initiative up until the end of the Arctic Council Swedish chairmanship in May 2013 is summarized in this report.DesignThe overall goals of the AHHI was to increase awareness and visibility of human health concerns of Arctic peoples, foster human health research, and promote health strategies that will improve health and well-being of all Arctic residents. Proposed activities to be recognized through the initiative included: expanding research networks that will enhance surveillance and monitoring of health issues of concern to Arctic peoples, and increase collaboration and coordination of human health research; fostering research that will examine the health impact of anthropogenic pollution, rapid modernization and economic development, climate variability, infectious and chronic diseases, intentional and unintentional injuries, promoting education, outreach and communication that will focus public and political attention on Arctic health issues, using a variety of publications, printed and electronic reports from scientific conferences, symposia and workshops targeting researchers, students, communities and policy makers; promoting the translation of research into health policy and community action including implementation of prevention strategies and health promotion; and promoting synergy and strategic direction of Arctic human health research and health promotion.ResultsAs of 31 March, 2009, the official end of the IPY, AHHI represented a total of 38 proposals, including 21 individual Expressions of Intent (EoI), and 9 full proposals (FP), submitted to the IPY Joint Committee for review and approval from lead investigators from the US, Canada, Greenland, Norway, Finland, Sweden and the Russian Federation. In addition, there were 10 National Initiatives (NI-projects undertaken during IPY beyond the IPY Joint Committee review process). Individual project details can be viewed at www.arctichealth.org. The AHHI currently monitors the progress of 28 individual active human health projects in the following thematic areas: health network expansion (5 projects), infectious disease research (7 projects), environmental health research (7 projects), behavioral and mental health research (4 projects), and outreach education and communication (5 projects).ConclusionsWhile some projects have been completed, others will contin...

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Mannose-Binding Lectin Genotypes and Susceptibility to Epstein-Barr Virus Infection in Infancy

Cited by 15 publications

References 27 publications

Torque Teno Virus Viremia Load Size in Patients with Selected Congenital Defects of Innate Immunity

Torque Teno Virus Viremia Load Size in Patients with Selected Congenital Defects of Innate Immunity

Predictors of Epstein-Barr virus serostatus and implications for vaccine policy: A systematic review of the literature

The Arctic Human Health Initiative: a legacy of the International Polar Year 2007–2009

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