Mannose‐binding protein in Chinese patients with systemic lupus erythematosus

Lau, Y. L.; Lau, Chak-Sing; Chan, Sum‐Yin; Karlberg, Johan; Turner, M. W.

doi:10.1002/art.1780390428

Cited by 82 publications

(64 citation statements)

References 10 publications

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“…No significant differences in these parameters could be (29) 89 (73) 27 ( 2 3 ) 26 (22) 21 (18) h l ( i ? ) 27 (23) 32 (27) 30 (25) 21 (18) 120 ( 11 (19) lU (17) 14 (23) 7 (17) 9 (15) 1 1 (10)…”

Section: 001)mentioning

confidence: 99%

Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

Mok

Lanchbury

Chan

et al. 1998

Arthritis & Rheumatism

218

130

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Objective. To study the genetic association of interleukin-10 (IL-10) promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus (SLE), and to investigate possible associations with clinical manifestations of the disease.Methods. DNA was extracted from 88 Chinese patients with SLE and 83 ethnically matched controls. The IL-10 promoter region between positions -533 and -1120 was amplified by polymerase chain reaction, and polymorphisms were detected by restriction-enzyme cleavage.Results. No significant difference in the allele or haplotype frequencies between SLE patients and controls could be demonstrated. The *A and aC alleles at the -597 position were linked to the *T and *C alleles at the -824 position, respectively. However, when clinical features were examined, the *A allele at the -597 position and the *T allele at the -824 position were significantly associated with lupus nephritis, by chisquare analysis ( 2 ' < 0.001, odds ratio 4.19, 95% confidence interval 2.02-8.71). Similarly, the haplotype -1087*A/-824*T/-597*A was also associated with renal involvement (P < 0.001, odds ratio 3.62, 95%confidence interval 1.80-7.31).Conchsion. IL-10 promoter polymorphisms are not strong determinants of susceptibility to the development of SLE, per se, in Southern Chinese individuals. However, IL-10 genotypes are strongly associated with certain clinical manifestations of SLE and may have a role in predicting disease prognosis.

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Section: 001)mentioning

confidence: 99%

Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

Mok

Lanchbury

Chan

et al. 1998

Arthritis & Rheumatism

218

130

View full text Add to dashboard Cite

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“…MBL deficiency in human serum has been associated with increased susceptibility to several infections (Lau et al, 1996;Garred et al, 1997;Summerfield et al, 1997;Davies et al,1997;Graudal et al, 1998;Koch et al, 2001). Infection by VL may be influenced directly by the level of MBL.…”

Section: Introductionmentioning

confidence: 99%

Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil

Silva¹,

Júnior²,

Monteiro³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Visceral leishmaniasis (VL) is one of the seven priority endemic diseases in the world. The clinical outcome of many infections is not only dependent on the pathogenic organism, but also on the genetic variability of the host susceptibility to infection. Mannose-binding lectin (MBL) is a Levels of mannose-binding lectin in leishmaniasis patients 19095©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 19094-19101 (2015) protein that plays an important role in the innate immune system. The aim of this study was to compare the serum levels of MBL between healthy controls and carriers of VL. The VL cases were recruited randomly from the main hospitals and referral outpatient clinics for VL in São Luís, and from home visits. Determination of MBL protein levels was performed by enzyme-linked immunosorbent assay. Of the 161 patients with VL and the 161 healthy controls, 60.9 and 67.1% had high levels of MBL, respectively. There was no significant difference in MBL levels between cases and controls. Low socioeconomic status and living conditions are conducive to the occurrence of VL. Owing to the small number of existing studies, it is extremely important to conduct further studies on MBL levels and susceptibility to VL, especially in regions where the disease is endemic, such as Maranhão, Brazil.

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“…5,6 A number of susceptibility genes, such as HLA, mannose-binding lectin gene, C4A, FcgR, tumor necrosis factor alpha gene (TNF-a) and programmed cell death 1 gene (PDCD1), have been reported to be associated with SLE among various populations. [7][8][9][10][11][12][13][14] In addition, total genome scan has been used in the mapping of chromosomal regions linked with SLE satisfying Lander and Kruglyak's criteria. [15][16][17][18][19][20][21][22] Several lines of evidence indicate that interleukin-10 gene (IL-10) is a strong candidate gene in SLE susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus

Chong

Wong

et al. 2004

Genes Immun

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Mannose‐binding protein in Chinese patients with systemic lupus erythematosus

Cited by 82 publications

References 10 publications

Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil

Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus

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