Mannose shows antitumour properties against lung cancer via inhibiting proliferation, promoting cisplatin‑mediated apoptosis and reducing metastasis

Abstract

it has been reported that mannose exerts antitumour effects against certain types of cancer. The present study was designed to evaluate whether mannose exerted potential anticancer effects on a549 and H1299 non-small cell lung cancer (nSclc) cells in vitro, which has not been reported previously. a cell counting Kit-8 cell viability assay was used to assess the antiproliferative effects of mannose on nSclc cells. Flow cytometry-based methods were used to evaluate the effects of mannose on the cell cycle distribution and cisplatin-mediated apoptosis of nSclc cells. Transwell migration and invasion assays were conducted to examine whether mannose could inhibit the invasive abilities of nSclc cells. The effects of mannose on the Pi3K/aKT and erK signalling pathways were explored through western blot analysis assessing the expression of phosphorylated (p)-aKT and p-erK1/2. it was found that mannose showed potential anticancer effects against nSclc cells in vitro by inhibiting proliferation, inducing G0/G1 cell cycle arrest, promoting cisplatin-induced apoptosis and decreasing the invasive abilities. These data indicate the potential anticancer properties of mannose and suggest the application of mannose-based therapies to treat nSclc. Cell Counting Kit-8 (CCK-8) assay. cell viability was detected with a ccK-8 assay (dojindo Molecular Technologies, inc.) according to the manufacturer's protocol. cancer cells

Fructose and Mannose in Inborn Errors of Metabolism and Cancer

“…Of note, a recent study has shown that the mannose uptake by a panel of cancer cells following millimolar mannose supplementation leads to the accumulation of M6P, which subsequently impairs glucose flux into central carbon metabolism and inhibits cancer growth [ 132 ]. In a similar vein, mannose supplementation was also shown to have an anticancer effect in non-small cell lung cancer (NSCLC) cells through inhibiting proliferation and increasing cell death [ 133 ]. Translating these recent findings into the antineoplastic role of mannose may lead to a novel route of treatment for cancer and improved outcomes for cancer patients.…”

Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients

“…These variations can be attributed to fructose‐mediated alterations in glycosylation structures, which have been associated with aggressive and metastatic phenotypes [ 66 ]. By contrast, mannose uptake by cancer cells impedes glucose flux into central carbon metabolism pathways, inhibiting cancer cell proliferation [ 67 ], and a recent study revealed that mannose supplementation has anticancer effects in NSCLC cells, inhibiting proliferation and increasing cell death [ 68 ]. The most important upregulated functional metabolites were related to metabolic pathways involved in energy metabolism and cell proliferation, such as glycerophospholipid metabolism, which had the highest impact score among the pathways associated with the stroma classifier.…”

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia

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