Mannosylated nanocarriers mediated site-specific drug delivery for the treatment of cancer and other infectious diseases: A state of the art review

Patil, Tulshidas S.; Deshpande, Ashwini

doi:10.1016/j.jconrel.2020.01.046

Cited by 48 publications

(22 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 2 B displays a representative flow cytometry histogram where the MFI illustrates fluorescence inside cells. These results are consistent with previous reports demonstrating the role played by mannose density on nanoparticle uptake by binding to mannose receptor CD206 externally displayed by macrophage [ 51 , 52 , 53 ].…”

Section: Resultssupporting

confidence: 94%

Mannose-Decorated Dendritic Polyglycerol Nanocarriers Drive Antiparasitic Drugs To Leishmania infantum-Infected Macrophages

et al. 2020

View full text Add to dashboard Cite

Macrophages are hosts for intracellular pathogens involved in numerous diseases including leishmaniasis. They express surface receptors that may be exploited for specific drug-targeting. Recently, we developed a PEGylated dendritic polyglycerol-based conjugate (PG–PEG) that colocalizes with intracellular parasite. We hereby study the effect of surface decoration with mannose units on the conjugates’ targeting ability toward leishmania intracellular parasites. Murine and human macrophages were exposed to fluorescently labeled mannosylated PG–PEG and uptake was quantified by flow cytometry analysis. Nanocarriers bearing five mannose units showed the highest uptake, which varied between 30 and 88% in the population in human and murine macrophages, respectively. The uptake was found to be dependent on phagocytosis and pinocytosis (80%), as well as clathrin-mediated endocytosis (79%). Confocal microscopy showed that mannosylated PG–PEGs target acidic compartments in macrophages. In addition, when both murine and human macrophages were infected and treated, colocalization between parasites and mannosylated nanoconjugates was observed. Leishmania-infected bone marrow-derived macrophages (BMM) showed avidity by mannosylated PG–PEG whereas non-infected macrophages rarely accumulated conjugates. Moreover, the antileishmanial activity of Amphotericin B was kept upon conjugation to mannosylated PG–PEG through a pH-labile linker. This study demonstrates that leishmania infected macrophages are selectively targeted by mannosylated PEGylated dendritic conjugates.

show abstract

Section: Resultssupporting

confidence: 94%

Mannose-Decorated Dendritic Polyglycerol Nanocarriers Drive Antiparasitic Drugs To Leishmania infantum-Infected Macrophages

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Anisamide variants have been conjugated to poly(ethyleneamine) (PEI) gold nanospheres [109] or PEGlyated AuNPs [110] to facilitate cell-specific internalization of siRNA-conjugated AuNPs, both in vitro and in vivo. Similar approaches have utilized NP conjugation of biotin [111], mannose [112,113] or hyaluronic acid (HA) [114,115] for targeted delivery to various cell types. Chan examined the effect of diameter on tumor uptake of spherical AuNPs, with and without targeting ligand (transferrin coating).…”

Section: Modulating Np-cell Interactionsmentioning

confidence: 99%

Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design

et al. 2021

View full text Add to dashboard Cite

Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with ”small” organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.

show abstract

“…C-type lectin receptors are Ca 2+ dependent carbohydrate recognition proteins and have multiple types including mannose receptor, macrophage galactose-type lectin-C and dectin receptor. Hence, different carbohydrate moieties are used to target C-type lectin receptors like mannose, glucose, D-galactose, N-acetyl-D-glucosamine (NAG) and maltose [110]. Recently, various mannose receptor targeting strategies involving mannose anchored liposomes, solid lipid nanoparticles, polymeric nanocarriers, niosomes, dendrimers and quantum dots have been fabricated to modulate macrophage function in the tumor [110].…”

Section: Tumor-associated Macrophages (Tams)mentioning

confidence: 99%

“…Hence, different carbohydrate moieties are used to target C-type lectin receptors like mannose, glucose, D-galactose, N-acetyl-D-glucosamine (NAG) and maltose [110]. Recently, various mannose receptor targeting strategies involving mannose anchored liposomes, solid lipid nanoparticles, polymeric nanocarriers, niosomes, dendrimers and quantum dots have been fabricated to modulate macrophage function in the tumor [110]. In this quest, biotin and mannose conjugated lipid-coated calcium zoledronate nanocarriers have shown higher internalization in both TAMs and cancer cells, restraining tumor growth, progression and angiogenesis [111].…”

Section: Tumor-associated Macrophages (Tams)mentioning

confidence: 99%

Onco-Receptors Targeting in Lung Cancer via Application of Surface-Modified and Hybrid Nanoparticles: A Cross-Disciplinary Review

et al. 2021

View full text Add to dashboard Cite

Lung cancer is among the most prevalent and leading causes of death worldwide. The major reason for high mortality is the late diagnosis of the disease, and in most cases, lung cancer is diagnosed at fourth stage in which the cancer has metastasized to almost all vital organs. The other reason for higher mortality is the uptake of the chemotherapeutic agents by the healthy cells, which in turn increases the chances of cytotoxicity to the healthy body cells. The complex pathophysiology of lung cancer provides various pathways to target the cancerous cells. In this regard, upregulated onco-receptors on the cell surface of tumor including epidermal growth factor receptor (EGFR), integrins, transferrin receptor (TFR), folate receptor (FR), cluster of differentiation 44 (CD44) receptor, etc. could be exploited for the inhibition of pathways and tumor-specific drug targeting. Further, cancer borne immunological targets like T-lymphocytes, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and dendritic cells could serve as a target site to modulate tumor activity through targeting various surface-expressed receptors or interfering with immune cell-specific pathways. Hence, novel approaches are required for both the diagnosis and treatment of lung cancers. In this context, several researchers have employed various targeted delivery approaches to overcome the problems allied with the conventional diagnosis of and therapy methods used against lung cancer. Nanoparticles are cell nonspecific in biological systems, and may cause unwanted deleterious effects in the body. Therefore, nanodrug delivery systems (NDDSs) need further advancement to overcome the problem of toxicity in the treatment of lung cancer. Moreover, the route of nanomedicines’ delivery to lungs plays a vital role in localizing the drug concentration to target the lung cancer. Surface-modified nanoparticles and hybrid nanoparticles have a wide range of applications in the field of theranostics. This cross-disciplinary review summarizes the current knowledge of the pathways implicated in the different classes of lung cancer with an emphasis on the clinical implications of the increasing number of actionable molecular targets. Furthermore, it focuses specifically on the significance and emerging role of surface functionalized and hybrid nanomaterials as drug delivery systems through citing recent examples targeted at lung cancer treatment.

show abstract

Mannosylated nanocarriers mediated site-specific drug delivery for the treatment of cancer and other infectious diseases: A state of the art review

Cited by 48 publications

References 78 publications

Mannose-Decorated Dendritic Polyglycerol Nanocarriers Drive Antiparasitic Drugs To Leishmania infantum-Infected Macrophages

Mannose-Decorated Dendritic Polyglycerol Nanocarriers Drive Antiparasitic Drugs To Leishmania infantum-Infected Macrophages

Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design

Onco-Receptors Targeting in Lung Cancer via Application of Surface-Modified and Hybrid Nanoparticles: A Cross-Disciplinary Review

Contact Info

Product

Resources

About