MannosylGlycodendritic Structure Inhibits DC-SIGN-Mediated Ebola VirusInfection in
            <i>cis</i>
            and in
            <i>trans</i>

Lasala, Fátima; Arce, Eva; Otero, Joaquín R.; Rojo, Javier; Delgado, Rafaël

doi:10.1128/aac.47.12.3970-3972.2003

Cited by 121 publications

(135 citation statements)

References 20 publications

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“…Since Ebola virus does not infect T-lymphocytes, its entry is absolutely dependent on DC-SIGN for infection of Jurkat cells. 30,37 Jurkat DC-SIGN + cells (2. The range of concentrations tested for compounds 17a-c was 1 pM -10 µM.…”

Section: Ebola Virus Infection Experimentsmentioning

confidence: 99%

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

et al. 2015

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Section: Ebola Virus Infection Experimentsmentioning

confidence: 99%

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

et al. 2015

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“…Additionally, it was demonstrated the antiviral properties of the mannosyl glycodendritic structure BH30sucMan using an Ebola Virus infection model. This glycodendritic hyperbranched polymer inhibited DC-SIGN-mediated Ebola Virus infection in cis and in trans (Lasala et al, 2003;Rojo, Delgado, 2004). The experiment showed that BH30sucMan was able to selectively inhibit direct DC-SIGN-mediated Ebola infection in an efficient dose-dependent manner (IC 50 337 nM).…”

Section: Boltorn-type Glycodendritic Structuresmentioning

confidence: 80%

Glycodendritic structures: tools to interact with DC-SIGN

Reina

Rojo

2013

Braz. J. Pharm. Sci.

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The key role of carbohydrates in many biological events has attracted the interest of the scientific community. This fact has demanded the access to new tools necessary to understand this role and the interaction of carbohydrates with their corresponding receptors, lectins. Glycodendrimers and glycodendritic structures in general, have demonstrated to be very efficient and interesting tools to intervene in those processes where carbohydrates participate. In this review, we discuss the different glycodendritic structures that have been used to interfere with DC-SIGN, a very attractive lectin involved in infection processes and in the regulation of the immune response.

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“…and trans infection process in a dose-dependent manner (IC 50 337 nM), by blocking the interaction of DC-SIGN with the envelope viral glycoprotein of Ebola, GP1 [56]. For comparison, an IC 50 1.3 mM was measured for the monovalent ligand α-methyl-D-mannopyranoside in the same experiment.…”

Section: Model the Third Generation Dendrimer (32 Mannose Units) Wasmentioning

confidence: 99%

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

Sattin

Bernardi

2016

Trends in Biotechnology

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Microbial adhesion is an essential step of infections and is mediated primarily by proteincarbohydrate interactions. Antagonists of such interactions have become a promising target for antiadhesive therapy in a number of infective diseases. Monovalent protein-sugar interactions are often weak, and most successful antiadhesive materials consist of multivalent glycoconjugates.Although often very effective in hampering microbial adhesion, natural epitopes often show limited resistance to enzymatic degradation. The use of carbohydrate mimics (glycomimetics) as a replacement for natural sugars potentially allows to achieve higher metabolic stability and also higher selectivity towards the desired protein target. In this review we will describe the state of the art on the design and synthesis of glycoconjugates and glycomimetics employed for the construction of antiadhesive biomaterials.

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MannosylGlycodendritic Structure Inhibits DC-SIGN-Mediated Ebola VirusInfection in cis and in trans

Cited by 121 publications

References 20 publications

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

Glycodendritic structures: tools to interact with DC-SIGN

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

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