Manometric tests of anorectal function in 90 healthy children: a clinical study from Kuwait

Kumar, Sunil; Ramadan, Saleema Al; Gupta, Vipul; Helmy, Safwat; Atta, Imran; Alkholy, Ashraf

doi:10.1016/j.jpedsurg.2009.01.008

Cited by 61 publications

(48 citation statements)

References 20 publications

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“…In addition, although a significant difference in vector volume, asymmetric index, and anal canal pressure was found between the LAARP and PSARP groups, we also noted significant variability within the same group. It has been observed that anorectal manometric values may vary with age [30]. However, because of limited case number in this study, we could not separate the patients into subgroups of different ages.…”

Section: Discussionmentioning

confidence: 86%

Laparoscopically assisted anorectal pull-through for high imperforate anus in infants: intermediate results

Tong¹,

Tang²,

Pu³

et al. 2011

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 86%

Laparoscopically assisted anorectal pull-through for high imperforate anus in infants: intermediate results

Tong¹,

Tang²,

Pu³

et al. 2011

Journal of Pediatric Surgery

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“…The rectal FLOQSwabs were specially designed such that they would sample just beyond the anal canal at the columnar epithelium. The swab has a lengthened flocked surface and a stopper at the 3.2-cm mark, which extends just proximal to the surgical anus of most children Ͻ3 years of age (19). Many of the bacterial and some of the protozoal pathogens of diagnostic interest reside in this anatomic location, and therefore, we hypothesized that this would be the ideal location to sample.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anatomically Designed Flocked Rectal Swabs for Molecular Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis in Botswana

et al. 2014

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f Two-hundred eighty matched bulk stool and anatomically designed flocked rectal swab samples were collected from children admitted to the hospital with acute diarrhea in Botswana. Their parents were asked about the acceptability of the swab collection method compared with bulk stool sampling. All samples underwent identical testing with a validated 15-target (9 bacterial, 3 viral, and 3 parasite) commercial multiplex PCR assay. The flocked swabs had a 12% higher yield for bacterial pathogen targets (241 versus 212; P ‫؍‬ 0.003) compared with that of stool samples, as well as similar yields for viral targets (110 versus 113; P ‫؍‬ 0.701) and parasite targets (59 versus 65; P ‫؍‬ 0.345). One hundred sixty-four of the flocked swab-stool pairs were also tested with separate laboratory-developed bacterial and viral multiplex assays, and the flocked rectal swabs had a performance that was similar to that seen with commercial assay testing. Almost all parents/guardians found the swabs acceptable. Flocked rectal swabs significantly facilitate the molecular diagnosis of diarrheal disease in children. Diarrheal disease remains a leading cause of global childhood morbidity and mortality, yet access to diagnostic laboratory testing is rarely available in much of the world. One of the barriers to diagnosing diarrheal disease, either for clinical or surveillance purposes, is the difficulty and time delays in obtaining and transporting a bulk stool specimen. Several investigators have sought to overcome this barrier through the use of rectal swab specimens for culture, molecular, and antigen testing, with variable results (1-5). Flocked swabs designed for respiratory and genitourinary sampling have been shown to acquire better samples than those acquired with more traditional spun fiber swabs (6, 7). We used a specially designed flocked rectal swab (FLOQSwabs; Copan Italia, Brescia, Italy) developed specifically for the diagnosis of diarrheal disease in children (Fig. 1) and then compared matched flocked rectal swabs to bulk stool samples in a clinical setting. The samples were collected from children admitted to the hospital in Botswana with severe acute gastroenteritis and tested using a U.S. FDAcleared commercial multiplex PCR assay in order to assess performance across a broad number of bacterial, viral, and parasitic pathogens.(These data were presented in part at the 29th Annual Clinical Virology Symposium, Daytona Beach, FL, 28 April to 1 May 2013, and at the Annual Pediatric Academic Society Meeting, Vancouver, Canada, 5 May 2014.) MATERIALS AND METHODSChildren Ͻ13 years of age who were admitted to the hospital with a diagnosis of acute gastroenteritis were enrolled prospectively at the Princess Marina Hospital in Gaborone, Botswana. Princess Marina Hospital is the largest referral hospital in Botswana.Clinical data were collected, and both the pediatric flocked rectal swab and bulk stool samples were obtained from each child as soon as possible after enrollment. The swab and stool samples were collected simultaneousl...

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“…Although anorectal manometry is now routinely used in the pediatric age group to diagnose Hirschsprung disease and to evaluate patients after anorectal surgery, the introduction of 3D-EAUS is a more recent innovation. Both procedures are well tolerated, safe, cost-effective, and minimally invasive [9].…”

mentioning

confidence: 99%

Three-dimensional endoanal ultrasound and anorectal manometry in children with anorectal malformations: new discoveries

Caldaro

Romeo

Angelis

et al. 2012

Journal of Pediatric Surgery

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Manometric tests of anorectal function in 90 healthy children: a clinical study from Kuwait

Cited by 61 publications

References 20 publications

Laparoscopically assisted anorectal pull-through for high imperforate anus in infants: intermediate results

Laparoscopically assisted anorectal pull-through for high imperforate anus in infants: intermediate results

Evaluation of Anatomically Designed Flocked Rectal Swabs for Molecular Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis in Botswana

Three-dimensional endoanal ultrasound and anorectal manometry in children with anorectal malformations: new discoveries

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