Mansonella perstans filariasis in Africa

Simonsen, Paul E.; Onapa, Ambrose; Asio, Santa Maria

doi:10.1016/j.actatropica.2010.01.014

Cited by 142 publications

(241 citation statements)

References 97 publications

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“…A history of ivermectin treatment for onchocerciasis was found in both cases and controls. Evidence of infection with Mansonella perstans, another insect vector-borne human filarial nematode, 28 was also significantly higher in cases than controls. By contrast, there was no difference in infection with Wucheria bancrofti, the nematode responsible for lymphatic filariasis.…”

Section: -2002mentioning

confidence: 93%

Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors

Spencer¹,

Vandemaele

Richer³

et al. 2013

Afr H. Sci.

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Background: Nodding Syndrome is a seizure disorder of children in Mundri County, Western Equatoria, South Sudan. The disorder is reported to be spreading in South Sudan and northern Uganda. Results: Nodding Syndrome was associated with Onchocerca volvulus and Mansonella perstans infections, with food use of a variety of sorghum (serena) introduced as part of an emergency relief program, and was inversely associated with a history of measles infection. There was no evidence to suggest exposure to a manmade neurotoxic pollutant or chemical agent, other than chemically dressed seed intended for planting but used for food. Food use of cyanogenic plants was documented, and exposure to fungal contaminants could not be excluded. Conclusion: Nodding Syndrome in South Sudan has an unknown etiology. Further research is recommended on the association of Nodding Syndrome with onchocerciasis/mansonelliasis and neurotoxins in plant materials used for food.

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Section: -2002mentioning

confidence: 93%

Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors

Spencer¹,

Vandemaele

Richer³

et al. 2013

Afr H. Sci.

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“…A remarkably diminished difference in NATOG concentration with high statistical significance (4.2 ± 0.7 μM; P < 0.001) was observed. Although these data suggest a metabolic specificity of NATOG for O. volvulus and the host, future sampling of other human filarial nematode species, such as Loa loa and Mansonella perstans, will help to establish a more complete picture of the metabolic regulation of NATOG and these other parasitic disease states (20).…”

Section: −8mentioning

confidence: 99%

Onchocerca volvulus -neurotransmitter tyramine is a biomarker for river blindness

Globisch

Moreno

Hixon

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Onchocerciasis, also known as “river blindness”, is a neglected tropical disease infecting millions of people mainly in Africa and the Middle East but also in South America and Central America. Disease infectivity initiates from the filarial parasitic nematode Onchocerca volvulus , which is transmitted by the blackfly vector Simulium sp. carrying infectious third-stage larvae. Ivermectin has controlled transmission of microfilariae, with an African Program elimination target date of 2025. However, there is currently no point-of-care diagnostic that can distinguish the burden of infection—including active and/or past infection—and enable the elimination program to be effectively monitored. Here, we describe how liquid chromatography-MS–based urine metabolome analysis can be exploited for the identification of a unique biomarker, N -acetyltyramine- O ,β-glucuronide (NATOG), a neurotransmitter-derived secretion metabolite from O. volvulus . The regulation of this tyramine neurotransmitter was found to be linked to patient disease infection, including the controversial antibiotic doxycycline treatment that has been shown to both sterilize and kill adult female worms. Further clues to its regulation have been elucidated through biosynthetic pathway determination within the nematode and its human host. Our results demonstrate that NATOG tracks O. volvulus metabolism in both worms and humans, and thus can be considered a host-specific biomarker for onchocerciasis progression. Liquid chromatography-MS–based urine metabolome analysis discovery of NATOG not only has broad implications for a noninvasive host-specific onchocerciasis diagnostic but provides a basis for the metabolome mining of other neglected tropical diseases for the discovery of distinct biomarkers and monitoring of disease progression.

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“…The quality control indicated that some laboratory technicians had difficulty differentiating W. bancrofti from Mansonella perstans , a much more common filarial parasite. 10 To make sure that no positive slides were missed, it was decided, after the first year's activities, that all slides would be reread.…”

Section: Methodsmentioning

confidence: 99%

A Laboratory-Based Surveillance System for Wuchereria bancrofti in Togo: A Practical Model for Resource-Poor Settings

Mathieu

Dorkenoo²,

Otogbe³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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One goal of the Global Program to Eliminate Lymphatic Filariasis (GAELF) is interruption of disease transmission through annual mass drug administration (MDA) in areas where LF prevalence is greater than 1%. After MDAs are completed, the World Health Organization (WHO) recommends a period of passive surveillance before final certification of LF elimination is achieved. Guidelines for such a surveillance system have yet to be developed. This paper describes a surveillance system launched in Togo in 2006. The system uses existing laboratories with technicians on call at night who, among other activities, prepare nocturnal thick blood smears for malaria diagnosis that can also be used for LF diagnosis. During its first 2 years (2006–2007), the system provided geographically disperse sampling nationwide, and 1 of 750 people residing in Togo was tested. Over the same period, the system detected two cases of LF, both from areas previously considered non-endemic. This system could be a cost-effective, sustainable model for WHO-mandated passive surveillance after cessation of MDA.

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Mansonella perstans filariasis in Africa

Cited by 142 publications

References 97 publications

Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors

Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors

Onchocerca volvulus -neurotransmitter tyramine is a biomarker for river blindness

A Laboratory-Based Surveillance System for Wuchereria bancrofti in Togo: A Practical Model for Resource-Poor Settings

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