Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern

Chang, Chung‐Che; Rowe, J. Jordi; Hawkins, Philip; Sadeghi, Ezedin M.

doi:10.1016/s1079-2104(03)00263-4

Cited by 31 publications

(24 citation statements)

References 30 publications

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“…Similar to previously published cases, our series of oral cavity MCL occurred more commonly in older men 5, 24-26. The finding of a mass, which may or may not be ulcerated, is the most common oral manifestation of NHLs 9,27.…”

Section: Discussionsupporting

confidence: 88%

Mantle cell lymphoma of the oral cavity: case series and comprehensive review of the literature

Guggisberg

Jordan

2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective-Mantle cell lymphoma (MCL) is a rare B cell neoplasm that has only recently been defined as a distinct entity. Because of its rarity and histological similarities with other small cell lymphomas, the microscopic diagnosis of MCL may be challenging. This is particularly true within the oral cavity where other lymphomas are more frequent. To date, few cases of MCL presenting within the oral cavity have been reported. Study Design-We present 2 new cases of MCL presenting within the oral cavity and systematically reviewed 7 other cases of MCL reported in the English language literature. Historical cases were reviewed and available data regarding morphology, special stains, demographics, clinical presentation, radiographic findings, management and outcome were extracted. Data from our current series was then compared with the earlier published literature.Results-To the best of our knowledge, this is the largest reviewed series of MCL within the oral cavity totaling 9 cases. The features of our cases, including histology, clinical presentation and outcome, are consistent with the 7 previously reported cases. The majority of oral MCLs occur in an older male population and a high proportion occur on the palate.Conclusion-We conclude that MCL of the oral cavity is an uncommon diagnosis. Most oral MCLs occur in an elderly male population and have a possible predilection for the palate. The microscopic diagnosis can be challenging given its similar appearance to other small cell lymphomas requiring a comprehensive immunohistochemical panel for the accurate diagnosis. Like MCL occurring in other sites in the body, the prognosis and outcome of oral MCL appears to be poor.

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Section: Discussionsupporting

confidence: 88%

Mantle cell lymphoma of the oral cavity: case series and comprehensive review of the literature

Guggisberg

Jordan

2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…A literature review has identified only three cases of MCL with palatine involvement to date (8)(9)(10). Because the gastrointestinal tract and Waldeyer's ring are common sites of MCL involvement (1-3), it is possible that palatine lesions represent an unusual manifestation of these two extranodal diseases.…”

Section: Discussionmentioning

confidence: 99%

Mantle Cell Lymphoma Presenting with a Tumor of the Hard Palate

et al. 2010

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We report a 71-year-old man with a disseminated disease of mantle cell lymphoma (MCL). He initially noticed instability of the maxillary denture due to swelling of the hard palate. Combined positron-emission tomography and computed tomography demonstrated a marked accumulation of fluorodeoxyglucose in the palate. A biopsy of the palatine tumor disclosed diffuse infiltrates of lymphoid cells, which were positive for CD 20 and cyclin D1. The peripheral blood contained lymphoma cells with the characteristic immunophenotype, and fluorescence in situ hybridization detected fusion signals indicative of t(11;14)(q13;q32). In a literature review we identified only three cases of MCL with palatine involvement to date.

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“…Although MCL of the gastrointestinal tract often affects the ileo-caecal region, involvement of the appendix by MCL has only been reported in two previous cases, to the best of our knowledge [2]. Palatal involvement is also exceptional in this lymphoma, with only one case being previously described [3].…”

Section: (Received 22 August 2005; Accepted 21 February 2006)mentioning

confidence: 94%

“…As for involvement of the palate by MCL, there has only been a single previously reported case [3]. B-cell lymphomas, including MCL, more often involve Waldeyer's ring, which is posterior to the palate [8].…”

Section: Subsequent Coursementioning

confidence: 99%

Involvement of the appendix and palate by pleomorphic variant mantle cell lymphoma

Tan

Soo

et al. 2006

Leukemia & Lymphoma

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Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern

Cited by 31 publications

References 30 publications

Mantle cell lymphoma of the oral cavity: case series and comprehensive review of the literature

Mantle cell lymphoma of the oral cavity: case series and comprehensive review of the literature

Mantle Cell Lymphoma Presenting with a Tumor of the Hard Palate

Involvement of the appendix and palate by pleomorphic variant mantle cell lymphoma

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