Manual Acupuncture Improved Quality of Life in Cancer Patients with Radiation-Induced Xerostomia

Cho, Jung Hyo; Chung, Weon Kuu; Kang, Weechang; Choi, Sun Mi; Cho, Chong Kwan; Son, Chang Gue

doi:10.1089/acm.2007.0793

Cited by 84 publications

(122 citation statements)

References 14 publications

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“…One trial 32 used a single-blind setting, and the placebo setting was considered as appropriate. The study by Pfister et al 33 had 6 patients lost to follow-up, but the missing outcome data were balanced between the 2 groups.…”

Section: Results Of Methodological Quality Assessmentmentioning

confidence: 99%

“…Selective reporting was found in the study by Pfister et al, 33 because it failed to include results that would be expected to have been reported for such a study, for example, the salivary flow rates. In the study by Cho et al, 32 subjects were not evenly divided based on disease-state characteristics, which we considered as a potential source of bias (see Figures 2 and 3 for overview).…”

Section: Results Of Methodological Quality Assessmentmentioning

confidence: 99%

“…36 So we extracted data on the volume of radiation delivered to the parotid. Only 1 study 32 described in detail the principles used in choosing acupuncture points-for this study, points that support salivary flow or water-like elements of the body were chosen. The points most frequently used were ST 36, LI 4, auricular of Shenmen, and the corresponding points in the ear (such as parotis, larynx, and mouth)…”

Section: Description Of the Included Studies And Data Analysismentioning

confidence: 99%

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The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

et al. 2012

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Background. Methods currently available to prevent and manage xerostomia which caused by radiotherapy in patients with head and neck caner have limited efficacy. Some studies suggest that acupuncture may be beneficial. Objectives. The authors evaluated the preventive and therapeutic effect of acupuncture for radiation-induced xerostomia among patients with head and neck cancer. Methods. PUBMED, EMBASE, Cochrane Library, CBM, CAJD, Wan Fang database, and VIP Database for Chinese Technical Periodicals were electronically searched, in conjunction with further manual search for relevant articles. Studies that met the inclusion criteria were systematically evaluated. Results. Three randomized controlled trials (RCTs) investigating the therapeutic effect of acupuncture were included. One RCT on the preventive effect of acupuncture was found. Because of the considerable variation among included studies, meta-analysis was not possible. Two included RCTs used placebo controls, and both observed significant improvement in the salivary flow rates between acupuncture and control groups. However, no significant differences were found. Three included RCTs suggested that acupuncture for radiation-induced xerostomia can improve patients' subjective symptoms. The only study evaluating the preventive effect of acupuncture for radiation-induced xerostomia showed positive changes in salivary flow rates (both unstimulated and stimulated) and dry mouth -related symptoms. Acupuncture treatment was well tolerated by all patients and no severe adverse effects were seen. Conclusions. Insufficient evidence is available to judge whether acupuncture is safe and whether it is effective in preventing or treating radiation-induced xerostomia. Significant research remains to be done before acupuncture can be recommended for routine use in radiation-induced xerostomia.

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Section: Results Of Methodological Quality Assessmentmentioning

confidence: 99%

Section: Results Of Methodological Quality Assessmentmentioning

confidence: 99%

Section: Description Of the Included Studies And Data Analysismentioning

confidence: 99%

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The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

et al. 2012

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“…Acupuncture: Acupuncture therapy for treating dry mouth produces a stimulation of the autonomic nervous system by increasing blood flow and in turn stimulating salivary flow 94 . Researchers have studied the use of acupuncture in patients with xerostomia induced by external beam radiotherapy applied twice a week for 6 weeks, and they managed to obtain satisfactory results in total unstimulated salivary flow 95 .…”

Section: Non-pharmacological Salivary Stimulationmentioning

confidence: 99%

Dental perspective on Sjögren’s syndrome: literature review

et al. 2015

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Abstract:The human body releases around 500-600mL of saliva daily, however when values of unstimulated whole saliva range from 0.1 to 0.2mL/ min, there is a condition called Hyposalivation or hyposialia. Hyposalia is characterized by a large number of systemic conditions, including Sjögren's syndrome, a chronic autoimmune disease that affects between 0.1 and 3% of the world population and is characterized by exocrinopathy of the salivary glands leading to glandular hypofunction and thus decreasing the normal salivary flow. Saliva is part of innate immunity, when there is a decrease in protein secretion, numerous oral manifestations occur such as dental caries, candidiasis, gingival disease, angular cheilitis, lymphomas of the salivary glands, dysphagia, erythematous and fissured tongue, among others. Currently there is no defined dental treatment, however there are alternative treatments by sialogogues and salivary substitutes, plus non-pharmacological therapies, which seek to maintain the ecology and oral conditions stable, in addition to preventive and restorative dental treatment for lesions already established as a consequence of the disease. The aim of this study is to conduct a literature review on the characteristics, classification, oral manifestations and dental management of Sjögren's syndrome.

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“…2,3 Preliminary evidence has suggested that acupuncture is a type of medical intervention that has demonstrated an ability to improve QoL in patients with cancer. [4][5][6][7][8][9] However, the impact of acupuncture in health-related QoL in the population of patients with ovarian cancer during chemotherapy has not been evaluated, especially in a randomized controlled clinical trial.…”

Section: Introduction Imentioning

confidence: 99%

The Feasibility and Effects of Acupuncture on Quality of Life Scores During Chemotherapy in Ovarian Cancer: Results from a Pilot, Randomized Sham-Controlled Trial

Matulonis

Dunn

et al. 2012

Medical Acupuncture

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Background: Within a pilot trial regarding chemotherapy-induced neutropenia, the secondary aim of the main study was explored. This involved measuring the effects-as shown on two key measurement scales reflecting quality of life (QoL)-of verum versus sham acupuncture on patients with ovarian cancer during chemotherapy. Objective: The aim of this substudy was to determine the feasibility of determining the effects of verum acupuncture versus sham acupuncture on QoL in patients with ovarian cancer during chemotherapy. Design: This was a randomized, sham-controlled trial. Setting: The trial was conducted at two cancer centers. Patients: Patients with ovarian cancer (N = 21) who were receiving chemotherapy-primarily intravenous carboplatin and paclitaxel-participated in this substudy. Intervention: The participants were given either active or sham acupuncture 1 week prior to cycle 2 of chemotherapy. There were ten sessions of acupuncture, with manual and electro-stimulation over a 4-week period. Main Outcome Measures: The European Organization for Research and Treatment of Cancer-Quality-of-Life Questionnaire-Core 30 Item (EORTC-QLQ-C30) and the Quality of Life Questionnaire-Ovarian Cancer Module-28 Item (QLQ-OV28) were administered to the patients at baseline and at the end of their acupuncture sessions. Results: Of the original 21, 15 patients (71%) completed the study, and 93% of them completed the questionnaires. The EORTC-QLQ-C30 subscores were improved in the acupuncture arm, including the mean scores of social function (SF), pain, and insomnia ( p = 0.05). However, after adjusting for baseline differences, only the SF score was significantly higher in the active acupuncture arm, compared with the sham acupuncture arm ( p = 0.03).

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Manual Acupuncture Improved Quality of Life in Cancer Patients with Radiation-Induced Xerostomia

Abstract: Our results showed the significantly meaningful amelioration of the subjective sensation of xerostomia closely associated with QOL in patients with head and neck cancer treated with irradiation.

Cited by 84 publications

References 14 publications

The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

The Preventive and Therapeutic Effect of Acupuncture for Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

Dental perspective on Sjögren’s syndrome: literature review

The Feasibility and Effects of Acupuncture on Quality of Life Scores During Chemotherapy in Ovarian Cancer: Results from a Pilot, Randomized Sham-Controlled Trial

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