Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) Although considerable data show that sleep deprivation alters many aspects of behavior, little is known about changes in the brain substrate underlying the behavioral effects, and even less is known about the cerebral effects of recovery sleep. The overarching objective of this study is to investigate the effects of 2 full nights of sleep loss (66 hours total) and 2 full nights of recovery sleep on cognitive performance and brain function. We have studied 40 individuals for 6 nights and 6 days. Over the course of this period, subjects received 4 polysomnograms and 10 functional magnetic resonance imaging (FMRI) sessions. During the FMRI sessions, functional brain imaging data was collected while subjects performed each of 3 cognitive tasks. These data provide a rich amount of information concerning the effects of prolonged total sleep deprivation and recovery sleep on cognitive performance and the cerebral underpinnings of that performance. Early analyses of these data are revealing the course of deterioration and recovery in cognitive performance, the specific component processes of cognition affected by sleep deprivation, and the changes in brain function associated with sleep deprivation. We have also initially reported distinct patterns of recovery for different sleep parameters after sleep deprivation, and the possibility of using the FMRI measures to identify neural correlates of vulnerability and resilience to sleep deprivation. References…………………………………………………………………………..… 6
REPORT DATE (DD-MM-YYYY)
01-08-2006
REPORT TYPE
Annual
DATES COVERED
SUBJECT TERMSAppendices……………………………………………………………………………. 7
INTRODUCTION:An ever-increasing number of military personnel and civilians alike must work daily without adequate sleep. Although considerable data show that sleep deprivation alters many aspects of behavior, including motor skills and cognitive performance, little is known about changes in the brain substrate underlying the behavioral effects. Even less is known about the cerebral effects of recovery sleep. The overarching objective of this study is to investigate the effects of 2 full nights of sleep...