Manual reaction times and brain dynamics after ‘awake surgery’ of slow-growing tumours invading the parietal area. A case report

Abstract

Primary objectives: Awake surgeries of slow growing tumors invading the brain and guided by direct electrical stimulation are accompanied by major brain reorganisations followed with slight impairments post-operatively. In most cases, these deficits are so slight after a few days that they are often not detectable on classical neuropsychological evaluations. Consequently, we investigated whether simple visuo-manual reaction times paradigms would sign some level of functional asymmetries between both hemispheres. Importantly, the visual stimulus was located in the saggital plan in order to limit attentional biases and to focus mainly on the interhemispheric asymmetry. Methods and procedures: Three patients (aged of 41, 59 and 59 years) after resections in parietal regions and a control group (age=44, SD 6.9) were compared during simple uni and bimanual reaction times (RTs).

Connectomic Networks and Their Impact on Clinical Outcomes in Glioma Treatment: A Review

“…[93][94][95] Preoperative brain plasticity and reorganization of the DAN and other attenuation networks in the setting of a lowgrade glioma may contribute to a patient's normal results on standard neuropsychological assessments, as surrounding regions may take on the eloquent roles and function of the invaded tissue. [96][97][98][99][100][101] This can be seen in patients with lowgrade glioma undergoing surgical resection who receive intraoperative electrical stimulation to assist in surrounding white matter tract preservation. Even during acute-phase postoperative deficits, complete recovery among these patients was possible within 3 months.…”

Functional reorganization of the attentional networks in low-grade glioma patients: A longitudinal study

“…8 Preservation of cognitive functions in lateralized target detection, visual exploration or line bisection is likely to be ensured by a very efficient functional reorganization that operates in parallel with tumour progression (see Desmurget et al, 2007 for a review). Pre-operative brain plasticity may enable the migration of the functions by modifying the underlying networks (Herbet, Lafargue, Bonnetblanc, Moritz-Gasser, & Duffau, 2013;Sallard, Barral, Duffau, & Bonnetblanc, 2012;. Desmurget et al (2007) , 5, 6, 8, 9, 12, 13, 14, 16, 17).…”

“Awake Surgery” of Slow-Growing Tumors and Cortical Excitability Measured by EEG Recordings: Preliminary Results

“…However, some level of functional asymmetry between both hands has been observed for these patients post-operatively (+ 4 to 5 days). Longer visuo-manual reaction times (RTs) were observed for the impaired hand [5]. This may sign some interhemispheric imbalance and especially post-lesional changes in cortical excitability.…”