“…32 Interestingly, although degenerative disc disease has long been thought to be an irreversible disease process, recent findings in vitro and in animal models have suggested that controlled loading and unloading of IVDs may result in some degree of regeneration. 17,24,25,30,33,38,43,48 Although the reason for this finding is unknown, improving diffusion of water in the IVDs by controlled loading and unloading of IVDs through the use of interventions such as lumbar traction, 7,11,12,23,46 joint manipulation, 9,12,26,45 repeated lumbar motions, 28,32 and graded abdominal muscle contraction 31 may be an important process that can favorably affect the internal chemical environment and mechanical properties of the degenerative IVD. However, it is currently unknown if this actually occurs.…”