Manufacture of macroporous β-tricalcium phosphate bioceramics

Descamps, M.; Duhoo, Thierry; Monchau, F.; Lu, Jianxi; Hardouin, Pierre; Hornez, Jean‐Christophe; Leriche, Anne

doi:10.1016/j.jeurceramsoc.2007.05.025

Cited by 140 publications

(100 citation statements)

References 25 publications

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“…Functionally graded bioceramics consisting of calcium orthophosphates only [575] have been developed [411,482,484,[578][579][580][581][582][583][584][585][586][587]. For example, dense sintered bodies with gradual compositional changes from α-TCP to HA were prepared by sintering a diamond-coated HA compacts at 1280 °C under a reduced pressure, followed by heating under the atmospheric conditions [578].…”

Section: Functionally Graded Bioceramicsmentioning

confidence: 99%

“…Thus, in various attempts to mimic the porous structure of bones, calcium orthophosphate bioceramics with graded porosity have been fabricated [375,411,482,484,[578][579][580][581][582][583][584][585]588]. For example, graded porous calcium orthophosphate bioceramics can be produced by means of tape casting and lamination (Fig.…”

Section: Functionally Graded Bioceramicsmentioning

confidence: 99%

“…Furthermore, submicron-sized HA powders are biodegraded even faster than the highly porous HA scaffolds. Other examples of bioresorbable materials include porous bioceramic scaffolds made of BCP (which is an intimate mixture of either β-TCP + HA [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] or α-TCP + HA [8][9][10][11][12]) or bone grafts (dense or porous) made of CDHA [152], TCP [411,596,597] and/or ACP [462,598]. One must stress that recently the concepts of bioactive and bioresorbable materials have converged and bioactive materials are made bioresorbable, while bioresorbable materials are made bioactive [599].…”

Section: Interaction With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

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Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Section: Functionally Graded Bioceramicsmentioning

confidence: 99%

Section: Functionally Graded Bioceramicsmentioning

confidence: 99%

Section: Interaction With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

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Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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“…The formation of β-TCP can be associated to the reduction of the pH during the reaction, due to formation of sulfuric acid during the reaction. However, β-TCP is a resorbable biomaterial and enhance the biological properties of monolithic HA [18,19]. Micrograph of PHB particles is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Production of polyhydroxybutyrate and hydroxyapatite (PHB/HA) composites for use as biomaterial

et al. 2017

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The composite materials using polyhydroxybutyrate as matrix and hydroxyapatite as reinforcement (PHB/HA) were produced by molding, using pressing at 100 MPa and 165 °C for 30 min. The amount of filler was varied from 0 to 20 wt% to evaluate the effect of the HA particles on mechanical properties and the bioactivity of the composites. The increase of the HA amount reduced the compressive strength of the composites nearly 20% while bending strength reduced nearly 30%. However, the bioactivity after 14 days immersion in SBF was improved with the increase of HA amount, with formation of apatite layer on the surface of the PHB/HA composite. Keywords: polyhydroxybutyrate, hydroxyapatite, composite, biomaterials. Resumo Materiais compósitos com matriz de poli-hidroxibutirato e material de reforço de hidroxiapatita (PHB

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“…The scaffolds were manufactured by impregnating an organic template with a calcium phosphate slurry according to the process of Descamps et al (Descamps et al, 2008). This allowed for full control of the round shape and diameter of the macro-pores (i.e.…”

Section: Scaffold Preparationmentioning

confidence: 99%

Validation of an in vitro 3D bone culture model with perfused and mechanically stressed ceramic scaffold

Bouet¹,

Cruel²,

Laurent³

et al. 2015

eCM

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An engineered three dimensional (3D) in vitro cell culture system was designed with the goal of inducing and controlling in vitro osteogenesis in a reproducible manner under conditions more similar to the in vivo bone microenvironment than traditional two-dimensional (2D) models. This bioreactor allows efficient mechanical loading and perfusion of an original cubic calcium phosphate bioceramic of highly controlled composition and structure. This bioceramic comprises an internal portion containing homogeneously interconnected macropores surrounded by a dense layer, which minimises fluid flow bypass around the scaffold. This dense and flat layer permits the application of a homogeneous loading on the bioceramic while also enhancing its mechanical strength. Numerical modelling of constraints shows that the system provides direct mechanical stimulation of cells within the scaffold. Experimental results establish that under perfusion at a steady flow of 2 µL/min, corresponding to 3 ≤ Medium velocity ≤ 23 µm/s, mouse calvarial cells grow and differentiate as osteoblasts in a reproducible manner, and lay down a mineralised matrix. Moreover, cells respond to mechanical loading by increasing C-fos expression, which demonstrates the effective mechanical stimulation of the culture within the scaffold. In summary, we provide a "proof-of-concept" for osteoblastic cell culture in a controlled 3D culture system under perfusion and mechanical loading. This model will be a tool to analyse bone cell functions in vivo, and will provide a bench testing system for the clinical assessment of bioactive bone-targeting molecules under load.

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Manufacture of macroporous β-tricalcium phosphate bioceramics

Cited by 140 publications

References 25 publications

Medical Application of Calcium Orthophosphate Bioceramics

Medical Application of Calcium Orthophosphate Bioceramics

Production of polyhydroxybutyrate and hydroxyapatite (PHB/HA) composites for use as biomaterial

Validation of an in vitro 3D bone culture model with perfused and mechanically stressed ceramic scaffold

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