Manufacture of Soft‐Hard Implants from Electrospun Filaments Embedded in 3D Printed Structures

Alkaissy, Rand; Richard, Michael; Morris, Hayley; Snelling, Sarah; Pinchbeck, Henry; Carr, Andrew; Mouthuy, Pierre‐Alexis

doi:10.1002/mabi.202270031

Cited by 3 publications

(2 citation statements)

References 80 publications

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“…Biphasic release offers the combined advantages of rapid and sustained release, holding promising applications in various fields such as cancer treatment [ 78 , 79 , 80 ], bone tissue regeneration [ 81 , 82 , 83 , 84 ], wound healing [ 85 , 86 , 87 , 88 ], rotator cuff tendon tears [ 89 ], and eye diseases [ 90 ].…”

Section: Drug Release Modes Of Drug-loaded Nanofibersmentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

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Section: Drug Release Modes Of Drug-loaded Nanofibersmentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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“…[ 25–30 ] Its versatility in terms of amenability to fabrication techniques, including electrospinning and 3D printing, makes it highly attractive for implant applications. [ 31–34 ] It is also employed in advanced large‐scale fabrication technologies, like pressurized gyration and nozzle‐pressurized gyration, for creating anisotropic microfibers. [ 35,36 ] Many studies have focused on conferring antimicrobial properties to PCL‐based materials through surface derivatization and novel synthetic approaches.…”

Section: Introductionmentioning

confidence: 99%

Probing the Effects of Antimicrobial‐Lysozyme Derivatization on Enzymatic Degradation of Poly(ε‐caprolactone) Film and Fiber

Maroju

Ganesan

Dutta

2023

Macromolecular Bioscience

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Surface derivatization is essential for incorporating unique functionalities into biodegradable polymers. Nonetheless, its precise effects on enzymatic biodegradation still lack comprehensive understanding. In this study, a facile solution‐based method is employed to surface derivatize poly(ε‐caprolactone) (PCL) films and electrospun fibers with lysozyme, aiming to impart antimicrobial properties and examine the impact on enzymatic degradation. The derivatized films and fibers have shown high antibacterial efficacy against E. coli and S. aureus. Through gravimetric analysis, it has been observed that the degradation rate experiences a slight decrease upon lysozyme derivatization. However, this reduction is effectively countered by the inclusion of Tween‐20, as affirmed by isothermal titration calorimetry. Comparing films and fibers, the latter undergoes degradation at a more accelerated pace, coupled with a rapid decline in molecular weight. This study provides valuable insights into the factors influencing the degradation of surface‐derivatized biopolymers through electrospinning, offering a simple strategy to mitigate biomaterial‐associated infections.This article is protected by copyright. All rights reserved

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