Manufacturing and assembly of an all-glass OCT microendoscope

Taege, Yanis; González-Cerdas, Gerardo; Jund, Felix; Zappe, Hans; Ataman, Çağlar

doi:10.1088/1361-6439/ac2d9d

Cited by 3 publications

(10 citation statements)

References 30 publications

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“…17 With a precision that can attain 1 to 5 μm depending on the specific structure, it allows for optomechanical designs that can be precisely tuned during production and assembly, facilitating the mounting and interconnection of components to provide a robust fabrication process. 11,12,18 To reach such tight fabrication tolerances, both the laser-writing and chemical etching steps of the process need to be fine-tuned through various iterations, which can be time-consuming and is not suitable for fast prototyping. However, once the appropriate control parameters have been found for a specific design, it can be easily replicated in batch.…”

Section: Manufacturing Of the Probe Head Assembly Platformmentioning

confidence: 99%

“…A detailed description of the design requirements and implementation of the probe head itself has been given by the authors in Ref. 12 and is summarized here for completeness. Since OCT is a scanned imaging technique, the probe head needs to feature a miniaturized laser scanner.…”

Section: Optomechanical Design and Medical-grade Encapsulationmentioning

confidence: 99%

“…This was fabricated through SLE (LightFab GmbH), a two-step subtractive 3D microstructuring process that can provide a selectivity of up to 1:1500 17 . With a precision that can attain 1 to 5 μm depending on the specific structure, it allows for optomechanical designs that can be precisely tuned during production and assembly, facilitating the mounting and interconnection of components to provide a robust fabrication process 11 , 12 , 18 . To reach such tight fabrication tolerances, both the laser-writing and chemical etching steps of the process need to be fine-tuned through various iterations, which can be time-consuming and is not suitable for fast prototyping.…”

Section: Fabrication and Assemblymentioning

confidence: 99%

“…An auxiliary structure was also manufactured to aid in the assembly of the glass holder and the focusing lens on the fiber tip, as previously presented by the authors in Ref. 12 and 18. The streamlined and precise process enabled by this approach allows for an increase in fabrication yield and reduces the assembly time, as well as the risk of damage or misalignment during the critical fixing steps.…”

Section: Fabrication and Assemblymentioning

confidence: 99%

See 3 more Smart Citations

Preclinical-grade microendoscope for optical coherence tomography and angiography inside the bladder

González-Cerdas

Taege

Jund

et al. 2023

J. Optical Microsystems

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We present a preclinical-grade, forward-viewing endomicroscope for in-contact optical coherence tomography (OCT) and optical coherence angiography (OCA) imaging through the working channel of a conventional cystoscope. Beam scanning is achieved with a fiber scanner driven by a tubular piezoelectric actuator. A focusing lens at the fiber tip helps engineering of the operation frequency within a compact probe length to avoid lateral undersampling. Microstructuring of fused silica through selective laser-induced etching was used for manufacturing a self-aligning housing for the probe head. The entire micro-optical system is assembled and encapsulated within a custom-developed sterilizable packaging with 4.5 mm outer diameter. The presented design and fabrication strategy can be used for any forward-viewing probe, independent of its imaging modalities. We demonstrate OCT imaging within a 2.1-mm diameter field of view at a transverse resolution of 19 μm and microvasculature visualization through OCA. The presented probe's mechanical characteristics and optical performance make it particularly attractive for outpatient care use in the detection of tissue pathology inside the bladder. The presented fabrication methodology provides a reliable strategy for enabling preclinical trials with endoscopic imaging probes.

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Section: Manufacturing Of the Probe Head Assembly Platformmentioning

confidence: 99%

Section: Optomechanical Design and Medical-grade Encapsulationmentioning

confidence: 99%

Section: Fabrication and Assemblymentioning

confidence: 99%

Section: Fabrication and Assemblymentioning

confidence: 99%

See 2 more Smart Citations

Preclinical-grade microendoscope for optical coherence tomography and angiography inside the bladder

González-Cerdas

Taege

Jund

et al. 2023

J. Optical Microsystems

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“…A number of laser scanning micro-endoscopes and probes have been developed in an effort to perform optical biopsies in-situ. These devices are typically equipped with 3Dscanning mechanism a comprising a combination of lateral and axial scanning MEMS chips [1][2][3][4], piezoelectric fiber scanners [5][6][7][8] and lens actuators [9]. Micromotors have been utilized in circumferential scanning devices, such as tethered * Author to whom any correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

A 3D-printed spiral actuator for focus adjustment in circumferential scanning endomicroscopy

Zog¹,

Gurcuoglu²,

Özdemir³

et al. 2022

J. Micromech. Microeng.

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We propose the utilization of laser scanning in wireless capsule endoscopy to provide high-resolution imaging at multiple depth sections throughout the gastrointestinal tract. The proposed device, targeted for confocal imaging, comprises a laser source and a light detector, a 3D-printed focus adjusting actuator to address different layers, a micro-motor for circumferential scanning, and batteries to provide energy to all units. It also involves a conformal antenna to transmit the acquired data to an external receiver unit and an integrated circuit to administer the entire operation. In this study, we showcase the design, manufacturing, and characterization of the focus adjustment actuator. The actuator has a spiral flexure, carrying a lens and multiple magnets at its center to facilitate focusing through electromagnetic actuation. The interplay between the spiral flexure length and the lens size is investigated for optimal performance. An external coil is utilized to drive the lens actuator with a low power (~ 5mW) to acquire data from targets placed at multiple depths, axially spanning a range of 5 mm. We also showcase data acquisition with reflective targets placed at different depths. Discussion on the integrated circuit and antenna design is also provided. With further development, the proposed device can be adapted for the clinical environment.

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Magnetic position sensing for self-calibration and image registration of scanning fiber endoscopes

Çalıkoğlu,

González-Cerdas,

Ilioae

et al. 2024

J. Optical Microsystems

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We present a magnetic position sensor for scanning fiber endoscopes to address their inherent short-and long-term position instability, which is a major hurdle before their widespread clinical deployment. The position sensor uses a ring-shaped micromagnet at the tip of the fiber cantilever, producing a dynamic magnetic field as the scanner resonates. A miniaturized three-dimensional Hall sensor accommodated within the endoscopic probe housing measures the magnetic field vector, which is then mapped directly to the beam position using closed-form calibration curves empirically obtained through a one-time calibration step using a position sensitive detector. By integrating the sensor into an OCT-endomicroscope recently developed in our group, we demonstrate an average position resolution of 20 μm over a field-ofview of 2.1 mm field-of-view and distortion-free OCT images recorded with various scan parameters. We also discuss how sub-pixel (e.g., better than half the diffraction-limited spot size) position resolution can be attained with the new sensing scheme.

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Manufacturing and assembly of an all-glass OCT microendoscope

Cited by 3 publications

References 30 publications

Preclinical-grade microendoscope for optical coherence tomography and angiography inside the bladder

Preclinical-grade microendoscope for optical coherence tomography and angiography inside the bladder

A 3D-printed spiral actuator for focus adjustment in circumferential scanning endomicroscopy

Magnetic position sensing for self-calibration and image registration of scanning fiber endoscopes

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