Manufacturing and characterisation of a novel composite dosage form for buccal drug administration

Innovative Use of an Injectable, Self-Healing Drug-Loaded Pectin-Based Hydrogel for Micro- and Supermicro-Vascular Anastomoses

“…Additionally, the drying method plays a crucial role; the hydrogel was air-dried rather than freeze-dried, a process which typically leads to larger pore sizes due to the slower removal of water, further deviating from the conventional porous hydrogel structure. Moreover, the SEM images of the powdered lidocaine in Figures S8e-h are in accordance with the literature 5,6 . Specifically, lidocaine has been shown to form visible crystalline structures in various formulations.…”

Innovative Use of an Injectable, Self-Healing Drug-Loaded Pectin-Based Hydrogel for Micro- and Supermicro-Vascular Anastomoses

“…Additionally, the drying method plays a crucial role; the hydrogel was air-dried rather than freeze-dried, a process which typically leads to larger pore sizes due to the slower removal of water, further deviating from the conventional porous hydrogel structure. Moreover, the SEM images of the powdered lidocaine in Figures S8e-h are in accordance with the literature 5,6 . Specifically, lidocaine has been shown to form visible crystalline structures in various formulations.…”

Development and evaluation of a composite dosage form containing desmopressin acetate for buccal administration

“…The MBF consisted of a mucoadhesive layer [2.5% chitosan (85% deacetylated), 6.0% hypromellose, 2.0% glycerol (85%), and 0.1 N HCl] ( Lindert, 2016 ) and a shield layer [12% ethyl cellulose, 2.5% triethylcitrate, 5.0% distilled water, and ethanol (99%) ad 100% ( V /V)]. The manufacturing process for these films has been previously described ( Kottke et al, 2020 ). In brief, the shield layer was cast discontinuously using a film-casting bench (Erichsen, Hemer, Germany), with a wet film thickness of 500 μm, and dried at 30 °C for two hours.…”

“…Properties such as disintegration and DDAVP release should be accomplished as quickly as possible to achieve the fastest possible permeation while ensuring constant adhesion to the oral mucosa. One possible solution could be the combination dosage form of a minitablet (MT) and a mucoadhesive bilayer film (MBF), such as that developed by our research group for the local drug delivery of lidocaine hydrochloride, which provided controllable and low levels of drug permeation ( Kottke et al, 2020 ). Minitablets are defined as tablets smaller than 3 mm, which is advantageous for applicability, especially among young children ( Freerks et al, 2020 ), and suitable for substances with stability problems.…”