Manufacturing and mechanical properties of calcium phosphate biomaterials

Laasri, Said; Taha, Mohammed A.; Hlil, E.K.; Laghzizil, A.; Hajjaji, A.

doi:10.1016/j.crme.2012.09.005

Cited by 24 publications

(14 citation statements)

References 18 publications

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“…Some pieces of Agadir and Safi natural rocks were characterized by Vickers hardness tests. The Vickers indenter is a 136 • square-based diamond pyramid and the Vickers hardness (HV) is calculated as the relation between the applied load F and the impression surface and it is defined by the following equation [20,22,23]:…”

Section: Ultrasonic Waves and Mechanical Propertiesmentioning

confidence: 99%

Characterization of Natural Gypsum Materials and Their Composites for Building Applications

et al. 2019

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Building retrofitting plays a key-role in energy saving and a growing interest is focused on insulating materials that allow a reduction in heat loss from envelopes with low thickness, by a process of reducing heating and cooling demand. In this context, a complete characterization of the physical properties of Moroccan natural gypsum materials was carried out. Basic information on the mineralogical, microstructure, thermal, mechanical, and acoustic characteristics of the rocks sampled from two Moroccan regions is provided. It was found that mineralogy, porosity, and water content are the main factors governing the development of the structure and the strength of the samples. The measured values of the porosity were 8.94%, the water content varied between 2.5–3.0% for the two studied typologies, coming from Agadir and Safi, respectively. Gypsum powder was used for fabricating samples, which were investigated in terms of thermal and acoustic performance. Thermal properties were measured by means of a hot disk apparatus and values of conductivity of 0.18 W/mK and 0.13 W/mK were obtained for Agadir and Safi Gypsum, respectively. The acoustic performance was evaluated in terms of absorption coefficient and sound insulation, measured by means of a Kundt’s Tube (ISO 10534-2). The absorption coefficients were slightly higher than the ones of conventional plasters with similar thickness. A good sound insulation performance was confirmed, especially for Safi Gypsum, with a transmission loss-value up to about 50 dB at high frequency.

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Section: Ultrasonic Waves and Mechanical Propertiesmentioning

confidence: 99%

Characterization of Natural Gypsum Materials and Their Composites for Building Applications

et al. 2019

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“…The Vickers micro-indentation method allows the calculation of fracture toughness from imprint edge cracks [10,11]. It is known that the critical stress intensity factor (KC) represents the resistance of a material to the sudden crack propagation.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…The influence of sintering temperature on the breaking stress shows that mechanical characteristic are enhanced to maximum levels at 1160°C and 1200°C respectively for β-TCP and HAp. Observed compressive strengths at these conditions are whining the range 45 to 50 MPa for both HAp and β-TCP [10]. In addition to microhardness, other mechanical properties are studied namely the yield and the compressive strengths.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Investigation of microstructure and mechanical properties of phosphocalcic bone substitute using the chemical wet method

Alimi¹,

Bahloul²,

Azzi³

et al. 2018

AIP Conference Proceedings

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Selection of calcium phosphate base materials in reconstructive bone surgery is justified by the surprising similarities in chemical compositions with human bones. The closest to natural apatite material is the hydroxyapatite (HAp) which has a chemical composition based on calcium and phosphate (Ca10(PO4)6(OH)2). In this study, HAp is synthesized using the wet precipitation method from hydrated calcium chloride (CaCl2,12H2O) and di-sodium hydrogen phosphate di-hydrate (HNa2PO4,2H2O). The powder is calcinated at 900°C and 1200°C in order to compare with sintered condition at 1150°C. Vickers microhardness tests and X-ray diffraction analyzes are used for the characterization of the crystalline material. Mechanical properties (HV, σe, σr, and KC) and the degree of crystallinity (Xc) are discussed according to heat treatment temperatures. Results indicate that heat treating the powder at 1200°C increased crystallinity up to 72%. At the same time, microhardness increased with temperature and even outmatched the sintered case at 1150°C. Fracture toughness is ameliorated with increasing heat treatment temperature by more than two folds. * Calculated (when needed) using Eq. 6. **Calculated (when needed) from compressive strength using Eq. 7.

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“…However, the use of β-TCP often gives rise to compromised bone regeneration in regions where the osseous environment is inactive owing to its limited osteoinductivity [ 8 , 9 ]. In addition, an agglomerate of β-TCP is susceptible to catastrophic failure due to its inferior fracture toughness and high Young’s modulus, which restricts its clinical use on load-bearing sites [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone‐graft substitute for accelerated craniofacial bone regeneration

Lee

Kim

et al. 2021

Biomater Res

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Background Bioceramic β-tricalcium phosphate (β-TCP) is used as a bone-grafting material and a therapeutic drug carrier for treatment of bone defects in the oral and maxillofacial regions due to the osteoconductivity and biocompatibility. However, the low mechanical strength and limited osteoinductivity of β-TCP agglomerate restrict bone regenerating performance in clinical settings. Methods Herein, a biomimetic composite is proposed as a bone morphogenetic protein-2 (BMP-2)-delivering bone graft substitute to achieve a robust bone grafting and augmented bone regeneration. Results The sequential processes of brown algae-inspired biosilicification and collagen coating on the surface of β-TCP enable the effective incorporation of BMP-2 into the coating layer without losing its bioactivity. The sustained delivery of BMP-2 from the biosilicated collagen and β-TCP composites promoted in vitro osteogenic behaviors of pre-osteoblasts and remarkedly accelerated in vivo bone regeneration within a rat calvarial bone defect. Conclusions Our multicomposite bone substitutes can be practically applied to improve bone tissue growth in bone grafting applications with further expansion to general bone tissue engineering.

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Manufacturing and mechanical properties of calcium phosphate biomaterials

Cited by 24 publications

References 18 publications

Characterization of Natural Gypsum Materials and Their Composites for Building Applications

Characterization of Natural Gypsum Materials and Their Composites for Building Applications

Investigation of microstructure and mechanical properties of phosphocalcic bone substitute using the chemical wet method

Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone‐graft substitute for accelerated craniofacial bone regeneration

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