Manufacturing functional hydrogels for inducing angiogenic–osteogenic coupled progressions in hard tissue repairs: prospects and challenges

Kumar, Anuj; Sood, Ankur; Singhmar, Ritu; Mishra, Yogendra Kumar; Thakur, Vijay Kumar; Han, Sung Soo

doi:10.1039/d2bm00894g

Cited by 22 publications

(12 citation statements)

References 126 publications

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“…Adequate angiogenesis is essential for the reconstruction and regeneration of the bone matrix during bone repair ( Kumar et al, 2022 ). Neovascularization provides essential nutrients and cytokines for bone regeneration to regulate the process of angiogenesis and osteogenesis ( Lee et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Zinc-energized dynamic hydrogel accelerates bone regeneration via potentiating the coupling of angiogenesis and osteogenesis

Lv,

Zhou,

Hong

et al. 2024

Front. Bioeng. Biotechnol.

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Insufficient initial vascularization plays a pivotal role in the ineffectiveness of bone biomaterials for treating bone defects. Consequently, enhancing the angiogenic properties of bone repair biomaterials holds immense importance in augmenting the efficacy of bone regeneration. In this context, we have successfully engineered a composite hydrogel capable of promoting vascularization in the process of bone regeneration. To achieve this, the researchers first prepared an aminated bioactive glass containing zinc ions (AZnBg), and hyaluronic acid contains aldehyde groups (HA-CHO). The composite hydrogel was formed by combining AZnBg with gelatin methacryloyl (GelMA) and HA-CHO through Schiff base bonding. This composite hydrogel has good biocompatibility. In addition, the composite hydrogel exhibited significant osteoinductive activity, promoting the activity of ALP, the formation of calcium nodules, and the expression of osteogenic genes. Notably, the hydrogel also promoted umbilical vein endothelial cell migration as well as tube formation by releasing zinc ions. The results of in vivo study demonstrated that implantation of the composite hydrogel in the bone defect of the distal femur of rats could effectively stimulate bone generation and the development of new blood vessels, thus accelerating the bone healing process. In conclusion, the combining zinc-containing bioactive glass with hydrogels can effectively promote bone growth and angiogenesis, making it a viable option for the repair of critical-sized bone defects.

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Section: Discussionmentioning

confidence: 99%

Zinc-energized dynamic hydrogel accelerates bone regeneration via potentiating the coupling of angiogenesis and osteogenesis

Lv,

Zhou,

Hong

et al. 2024

Front. Bioeng. Biotechnol.

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“…In summary, research on hydrogel-based immunotherapy for melanoma is advancing rapidly, and drug delivery technology is constantly improving ( 89 , 90 ), but there are still obstacles to translating the materials from the experimental stage to clinical application. First, biological materials are foreign substances to human organisms, and acute or chronic inflammation may occur in the body in response to the degradation of biological substances.…”

Section: Discussionmentioning

confidence: 99%

Research progress on hydrogel-based drug therapy in melanoma immunotherapy

He,

Zhang,

et al. 2024

BMB Rep

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Melanoma is one of the most aggressive skin tumors, and conventional treatment modalities are not effective in treating advanced melanoma. Although immunotherapy is an effective treatment for melanoma, it has disadvantages, such as a poor response rate and serious systemic immune-related toxic side effects. The main solution to this problem is the use of biological materials such as hydrogels to reduce these side effects and amplify the immune killing effect against tumor cells. Hydrogels have great advantages as local slow-release drug carriers, including the ability to deliver antitumor drugs directly to the tumor site, enhance the local drug concentration in tumor tissue, reduce systemic drug distribution and exhibit good degradability. Despite these advantages, there has been limited research on the application of hydrogels in melanoma treatment. Therefore, this article provides a comprehensive review of the potential application of hydrogels in melanoma immunotherapy. Hydrogels can serve as carriers for sustained drug delivery, enabling the targeted and localized delivery of drugs with minimal systemic side effects. This approach has the potential to improve the efficacy of immunotherapy for melanoma. Thus, the use of hydrogels as drug delivery vehicles for melanoma immunotherapy has great potential and warrants further exploration.

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“…The RA prevascular stage is brief before progressing to a major vascular stage with an obvious rise in vessel formation [ 44 ]. An increase in macrophages and fibroblast synoviocytes is an indication of the prevascular stage in the lining layer [ 45 ].…”

Section: Neovascularization and Ramentioning

confidence: 99%

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review

Atta,

Salem,

El-Said

et al. 2024

Cell Mol Biol Lett

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Rheumatoid arthritis (RA) is an autoimmune disease involving T and B lymphocytes. Autoantibodies contribute to joint deterioration and worsening symptoms. Adenosine deaminase (ADA), an enzyme in purine metabolism, influences adenosine levels and joint inflammation. Inhibiting ADA could impact RA progression. Intracellular ATP breakdown generates adenosine, which increases in hypoxic and inflammatory conditions. Lymphocytes with ADA play a role in RA. Inhibiting lymphocytic ADA activity has an immune-regulatory effect. Synovial fluid levels of ADA are closely associated with the disease’s systemic activity, making it a useful parameter for evaluating joint inflammation. Flavonoids, such as quercetin (QUE), are natural substances that can inhibit ADA activity. QUE demonstrates immune-regulatory effects and restores T-cell homeostasis, making it a promising candidate for RA therapy. In this review, we will explore the impact of QUE in suppressing ADA and reducing produced the inflammation in RA, including preclinical investigations and clinical trials. Graphical Abstract

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Manufacturing functional hydrogels for inducing angiogenic–osteogenic coupled progressions in hard tissue repairs: prospects and challenges

Abstract: In large bone defects, inadequate vascularization within the engineered-constructs has been a major challenge in developing clinically impactful product. It is fairly determined that the bone tissue and blood vessels...

Cited by 22 publications

References 126 publications

Zinc-energized dynamic hydrogel accelerates bone regeneration via potentiating the coupling of angiogenesis and osteogenesis

Zinc-energized dynamic hydrogel accelerates bone regeneration via potentiating the coupling of angiogenesis and osteogenesis

Research progress on hydrogel-based drug therapy in melanoma immunotherapy

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review

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