Manufacturing hydroxyapatite scaffold from snapper scales with green phenolic granules as the space holder material

Indra, Ade; Hamid, Irfan; Farenza, Jerry; Handra, Nofriady; Anrinal,; Subardi, Adi

doi:10.1016/j.jmbbm.2022.105509

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…In comparison to space-holder technology [15,16] and the foaming method [17], 3D printing technology offers significant advantages in terms of the appearance shape, porosity, aperture, pore shape, and spatial arrangement control of titanium scaffolds. 3D printing technology includes a variety of methods, mainly including: digital light processing (DLP), fused deposition modeling (FDM), stereoscopic light curing molding (SLA), powder bed fusion (PBF) and material jetting (MJ).…”

Section: Discussionmentioning

confidence: 99%

Investigating mechanical properties of 3D printed porous titanium scaffolds for bone tissue engineering

Yang,

Qin,

et al. 2024

Mater. Res. Express

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Objective:Three-dimensional (3D) printed porous titanium scaffolds serve as a bone tissue engineering technology that offers a promising solution for addressing bone defects. The scaffold's pore structure offers structural support and facilitates the proliferation of bone cells. Therefore, investigating the aperture and pore shape is of crucial for the development of 3D printed porous titanium scaffolds.Methods:Ti6Al4V scaffolds with the specified structure were fabricated using selective laser melting (SLM) technology. The scaffolds comprised fifteen cylindrical models measuring 20 mm in diameter and 20 mm in height. These models featured five scaffold shapes: imitation diamond-60°, imitation diamond-90°, imitation diamond-120°, regular tetrahedron and regular hexahedron. Each of these structural shapes was characterized by three different aperture sizes (400 μm, 600 μm and 800 μm). The porosity and mechanical properties of Ti6Al4V scaffolds were examined.Results:The measured porosity of Ti6Al4V scaffolds varied between 56.50% and 95.28%. The porosity increased with the size of the aperture. The mechanical properties tests revealed that, for identical apertures, the compressive strength and torsional strength were influenced by the configuration of the unit structure. Furthermore, the positive and lateral compressive strength as well as torsional strength of various unit structures exhibited distinct advantages and disadvantages. Within a uniform unit structure shape, the compressive strength and torsional strength were found to be correlated with the size of apertures, indicating that larger apertures result in decreased compressive and torsional strength.Conclusion:The configuration of the aperture and the shape of the pore were identified as significant factors that influenced the compressive strength. The compressive strength of Ti6Al4V scaffolds with various unit structure shapes exhibited both advantages and disadvantages when subjected to positive, lateral, and torsional forces. The enlarged aperture augmented the scaffold's porosity while diminishing its compressive and torsional strength.

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Section: Discussionmentioning

confidence: 99%

Investigating mechanical properties of 3D printed porous titanium scaffolds for bone tissue engineering

Yang,

Qin,

et al. 2024

Mater. Res. Express

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“…It worked by depositing a 45 vol% hydroxyapatite slurry forming a ceramic network of perpendicularly oriented layers of bars, as illustrated in Fig 1B . This material was chosen since bioceramics are proven to enhance naïve tissue growth by regulating osteoblast proliferation and differentiation while the structure is reabsorbed [48]. From previous works in the literature, the concentration of colloidal suspensions in the 3D-printing ink (45 vol%) was optimized to obtain the suitable viscoelastic properties for an effective deposition and assembly while ensuring the proper mechanical performance of the sintered structure in vivo [49][50][51]. An example of the final geometry of the patient-specific scaffold is provided in the S1 File of the Supporting Information.…”

Section: Design and Fabrication Of The Scaffoldmentioning

confidence: 99%

Gait analysis: An effective tool to mechanically monitor the bone regeneration of critical-sized defects in tissue engineering applications

Blázquez-Carmona,

Mora-Macías,

Morgaz

et al. 2023

PLoS ONE

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Introduction Tissue engineering has emerged as an innovative approach to treat critical-size bone defects using biocompatible scaffolds, thus avoiding complex distraction surgeries or limited stock grafts. Continuous regeneration monitoring is essential in critical-size cases due to the frequent appearance of non-unions. This work evaluates the potential clinical use of gait analysis for the mechanical assessment of a tissue engineering regeneration as an alternative to the traditional and hardly conclusive manual or radiological follow-up. Materials and methods The 15-mm metatarsal fragment of eight female merino sheep was surgically replaced by a bioceramic scaffold stabilized with an external fixator. Gait tests were performed weekly by making the sheep walk on an instrumented gangway. The evolution of different kinematic and dynamic parameters was analyzed for all the animal’s limbs, as well as asymmetries between limbs. Finally, potential correlation in the recovery of the gait parameters was evaluated through the linear regression models. Results After surgery, the operated limb has an altered way of carrying body weight while walking. Its loading capacity was significantly reduced as the stance phases were shorter and less impulsive. The non-operated limbs compensated for this mobility deficit. All parameters were normalizing during the consolidation phase while the bone callus was simultaneously mineralizing. The results also showed high levels of asymmetry between the operated limb and its contralateral, which exceeded 150% when analyzing the impulse after surgery. Gait recovery significantly correlated between symmetrical limbs. Conclusions Gait analysis was presented as an effective, low-cost tool capable of mechanically predicting the regeneration of critical-size defects treated by tissue engineering, as comparing regeneration processes or novel scaffolds. Despite the progressive normalization as the callus mineralized, the bearing capacity reduction and the asymmetry of the operated limb were more significant than in other orthopedic alternatives.

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3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity

Shan¹,

Bai²,

Yang³

et al. 2023

Journal of Advanced Ceramics

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In bone tissue engineering, scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration, attracting increasingly interests in clinical practice. In this study, strontium-incorporated β-tricalcium phosphate (β-TCP), named Sr-TCP, bioceramic triply periodic minimal surface (TPMS) structured scaffolds were successfully fabricated by digital light processing (DLP)-based 3D printing technique, achieving high porosity, enhanced strength, and excellent bioactivity. The Sr-TCP scaffolds were first characterized by element distribution, macrostructure and microstructure, and mechanical properties. Notably, the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%, bringing a great mechanical breakthrough to porous scaffolds. Furthermore, the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line (MC3T3-E1) cells in both gene and protein aspects, verified by alkaline phosphatase (ALP) activity and polymerase chain reaction (PCR) assays. Overall, the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity, boosted strength, and superior bioactivity at the same time, serving as a promising approach for bone regeneration.

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Manufacturing hydroxyapatite scaffold from snapper scales with green phenolic granules as the space holder material

Cited by 3 publications

References 61 publications

Investigating mechanical properties of 3D printed porous titanium scaffolds for bone tissue engineering

Investigating mechanical properties of 3D printed porous titanium scaffolds for bone tissue engineering

Gait analysis: An effective tool to mechanically monitor the bone regeneration of critical-sized defects in tissue engineering applications

3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity

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