Manufacturing methods and applications of membranes in microfluidics

Chen, Xueye; Shen, Jienan; Hu, Zengliang; Huo, Xuyao

doi:10.1007/s10544-016-0130-7

Cited by 33 publications

(17 citation statements)

References 112 publications

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“…Indeed, any additive used during the manufacturing may be harmful in vivo if able to migrate from PET fibers into the host tissues. The presence of additive traces should be carefully identified prior to implantation by means of high sensitivity detection techniques . Moreover, physicochemical characterization of mesh explants revealed the presence of chemical species transferred from the host tissues to the polymer during long‐term implantation.…”

Section: Discussionmentioning

confidence: 99%

Interplay between physicochemical and mechanical properties of poly(ethylene terephthalate) meshes for hernia repair

Todros

Pavan

Pachera

et al. 2017

J of Applied Polymer Sci

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Non-medical-grade industrial nets are often implemented in developing countries as affordable alternative to surgical meshes for hernia repair. Even if there is clear evidence about their repairing reliability, their physicochemical and mechanical properties have been not fully investigated. This works compares three industrial nets with different textile patterns, and a surgical mesh of the same polymer. Nets are autoclave-sterilized and characterized through scanning electron microscope, Raman spectroscopy, thermogravimetric analysis , differential scanning calorimetry, and uniaxial tensile tests. Spectral and thermal analyses reveal that all samples are based on poly(ethylene terephthalate). Differences are found in phase conformations with modifications in amorphous, ordered amorphous, and crystalline domains. Changes in material characteristics do not affect mechanical properties, which are mainly ascribable to the textile pattern. Industrial nets show a stiffening behavior different from the almost linear anisotropic response of surgical mesh. However, non-medical-grade nets could be potentially applied for surgeries once their biocompatibility and in vivo stability have been evaluated. Non-medical-grade industrial nets are used as low-cost alternative to surgical meshes for hernia repair in less developed countries. Nets sterilization modifies their phase conformation, due to the interaction with water, but do not affect mechanical properties. Even tough industrial nets show a different stiffening behavior, physicochemical characterization confirms a similarity to standard surgical meshes.

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Section: Discussionmentioning

confidence: 99%

Interplay between physicochemical and mechanical properties of poly(ethylene terephthalate) meshes for hernia repair

Todros

Pavan

Pachera

et al. 2017

J of Applied Polymer Sci

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“…Fouling by colloidal particles remains a major issue in many industrial processes including particle synthesis and solid handling in microreactors, membrane filtration, and liquid chromatography, often leading to complete stoppage of the process [1]. Even though this clogging issue is specific to each application, some generic features have been identified thanks to the use of microfluidic technology coupled with various imaging techniques such as confocal microscopy [2][3][4][5][6][7]. This technology enables the design of microdevices with complex geometries [8] that mimic industrial processes, in particular membrane filtration, and inside these devices we can follow the capture or deposition of colloidal particles over time, at the pore scale level, using diverse microscopy techniques.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of pore fouling by colloidal particles at the particle level

Dersoir

Schofield

Vincent

et al. 2019

Journal of Membrane Science

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Particle filtration occurs whenever particles flow through porous media such as membrane. Progressive capture or deposition of particles inside porous structure often leads to complete, and generally unwanted, fouling of the pores. Previously there has been no experimental work that has determined the particle dynamics of such a process at the pore level, since imaging the particles individually within the pores remains a challenge. Here, we overcome this issue by flowing fluorescently dyed particles through a model membrane, a microfluidic filter, imaged by a confocal microscope. This setup allows us to determine the temporal evolution of pore fouling at the particle level, from the first captured particle up to complete blocking of the pore. We show that from the very beginning of pore fouling the immobile particles inside the pore significantly participate in the capture of other flowing particles. For the first time it is determined how particles deposit inside the pore and form aggregates that eventually merge and block the pore.

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“…With the development of microfabrication technologies in the last decade, microfluidic membrane filtration combining microfluidics and membrane technologies has become a promising research area [30][31][32]. Many different fabrication methods integrating membranes into a microfluidic device have been proposed, e.g., direct incorporation of membranes in microchannels and incorporation of membranes during lithography processes.…”

Section: Introductionmentioning

confidence: 99%

Design Optimization for a Microfluidic Crossflow Filtration System Incorporating a Micromixer

et al. 2019

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In this study, we report on a numerical study on design optimization for a microfluidic crossflow filtration system incorporated with the staggered herringbone micromixer (SHM). Computational fluid dynamics (CFD) and the Taguchi method were employed to find out an optimal set of design parameters, mitigating fouling in the filtration system. The flow and the mass transfer characteristics in a reference SHM model and a plain rectangular microchannel were numerically investigated in detail. Downwelling flows in the SHM model lead to backtransport of foulants from the permeable wall, which slows down the development of the concentration boundary layer in the filtration system. Four design parameters -the number of grooves, the groove depth, the interspace between two neighboring grooves, and the interspace between half mixing periodswere chosen to construct a set of numerical experiments using an orthogonal array L 9 (3 4 ) from the Taguchi method. The Analysis of Variance (ANOVA) using the evaluated signal-to-noise (SN) ratios enabled us to identify the contribution of each design parameter on the performance. The proposed optimal SHM model indeed showed the lowest growth rate of the wall concentration compared to other SHM models.

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Manufacturing methods and applications of membranes in microfluidics

Cited by 33 publications

References 112 publications

Interplay between physicochemical and mechanical properties of poly(ethylene terephthalate) meshes for hernia repair

Interplay between physicochemical and mechanical properties of poly(ethylene terephthalate) meshes for hernia repair

Dynamics of pore fouling by colloidal particles at the particle level

Design Optimization for a Microfluidic Crossflow Filtration System Incorporating a Micromixer

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