Manufacturing of Medicate Chewing Gum Against Oral Pathogens by the Extract of Seeds of Lepidium sativum L.

Abstract

The results of the qualitative chemical detection of the active ingredients revealed that the Lepidium sativum L. (SLS) extract contained on the tannins, flavonoids, and saponines, as well as resins and alkaloids but lacked the glycosides. As well as determination of total phenols in SLS extract 44.72 mg/g also flavonoids 19.96 mg/g. Medical gum was manufactured from the following ingredients gum base, glycerine, xylitol, sun flower oil, flavor and color with the addition of the extract tested with different concentration (1.5 and 2.5 mg/g), the release of phenols compounds of chewing gum samples were estimated after each period of crushing the sample of gum in phosphate buffer. It was found that the ratio of the release of tis group of active compounds (phenols) increased with the increase of the duration of crushing gum samples until reaching 100% for all samples after 20 min. The results showed that sample of gum added to the extract (1.5 mg/g) was acceptable and no significant differences was found in comparison to the control treatment except for the sample added to the SLS extract at a concentration of 2.5 mg/g which was not accepted by the consumer due to the unpalatable taste.