Electrospun
micro/nanofibers have gained popularity recently for
flexible biomechanical sensors because of their advantages of lightness,
compatibility, breathability, mechanical deformability, and function
integrability, etc., offering them unprecedented sensitivities and
versatilities. With increasing advances in the digital era, existing
electrospun flexible sensors are not capable of catering to the demands
of multiscenario applications including wearable electronics, interactive
interfaces, and real-time continuous health monitoring. To ease and
expedite their developments, we thoroughly reviewed their latest progress
regarding design, preparation, and optimization. First, a brief overview
of the design approaches of electrospun flexible biomechanical sensors
based on the working mechanism is highlighted. Then, two kinds of
preparation strategies including direct electrospinning and post-treatment-assisted
electrospinning are discussed in detail. Further, four means for optimizing
the performance and endowing multifunctions to electrospun flexible
biomechanical sensors are demonstrated in terms of processing. Accordingly,
the challenges and the potential solutions related to this topic are
addressed, providing a future direction for the next generation of
electrospun flexible biomechanical sensors.