Manuka Honey: A Tissue Engineering Essential Ingredient

Speer, Shannon L.; Schreyack, Gretchen E

doi:10.4172/2157-7552.1000e130

Cited by 19 publications

(27 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the New Zealand Manuka honey (MH), derived from Leptospermum scoparium, is very attractive because of the remarkable non-peroxide antibacterial activity of methylglyoxal (MGO, or Unique Manuka Factor). Since 2015, when Manuka honey was defined "a tissue engineering essential ingredient" (Speer, et al, 2015), it was employed as diet supplement or wound dresser in combination with chitosan (Carter et al, 2016;Sasikala & Durai, 2015). However, at the best of our knowledge, the neat Manuka honey has never been exploited to synthesise implantable hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair

Bonifacio

Cometa²,

Cochis

et al. 2018

Carbohydrate Polymers

View full text Add to dashboard Cite

Biomaterials for cartilage repair are still far from clinical requirements, even if several studies recently focused on this topic. In this respect, Nature-derived hydrogels are a promising class of scaffolds for cartilage tissue engineering, mimicking the native cellular microenvironment. However, they frequently lack mechanical features required for cartilage applications and are commonly subjected to infection threat. This work describes the innovative use of Manuka honey as molecular spacer for preparing gellan gum-based composites with intrinsic antibacterial properties and superior compressive Young's modulus in respect of several Nature-derived gels based on chitosan, hyaluronic acid or alginate. The addition of Manuka honey made hydrogels able to inhibit the proliferation of S. aureus and S. epidermidis clinical isolates. Furthermore, no cytotoxic effects were detected on human mesenchymal stem cells seeded on the hydrogels. Moreover, chondrogenesis experiments showed a consistent expression of collagen II and high synthesis of GAGs and proteoglycans, thus indicating the formation of cartilage matrix. Overall, these data suggest that the developed smart composites have a great potential as tools for cartilage tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair

Bonifacio

Cometa²,

Cochis

et al. 2018

Carbohydrate Polymers

View full text Add to dashboard Cite

show abstract

“…More recently, with the rise of antibiotic resistant bacteria, honey use has experienced a clinical resurgence. Manuka honey (MH) is produced from the nectar of the Leptospermum scoparium tree native to New Zealand . This unique honey has demonstrated inhibitory effects instigated by a variety of its basic components including methylglyoxal and leptosperin .…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, the methylglyoxal (MGO), referred to as the Unique Manuka Factor (UMF), has been identified as being at least partially responsible for MH's anti‐bacterial effects . In addition to the UMF, MH also utilizes low levels of hydrogen peroxide, similarly to other honeys, for bacterial clearance . During the degradation of honey, glucose is broken down into gluconic acid and hydrogen peroxide where the hydrogen peroxide has been shown to possess antiseptic properties .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, honey is hygroscopic, removing moisture from the wound site, thus dehydrating the bacteria . Manuka honey is known to have a low pH, from 3.2 to 4.5, which is an additional factor in bacterial clearance and can encourage angiogenesis at the wound site . Honey also has inflammation modulation effects that have demonstrated promotion of wound healing and avoidance of an extended inflammatory response …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds incorporated with Manuka honey for the treatment of chronic bone infections

Hixon

Carletta

et al. 2017

J Biomed Mater Res

View full text Add to dashboard Cite

Previous studies have identified honey as an agent in bacterial inhibition and a mediator in lowering the pH at the wound site. Manuka honey (MH), indigenous to New Zealand, contains a Unique Manuka Factor that provides an additional antibacterial agent. While there are many potential benefits to incorporating MH into wounds, there is currently no ideal way to deliver the material to the site of injury. Cryogels are a type of scaffold that possess high porosity, mechanical stability, and a sponge-like consistency. This study uniquely incorporates varying amounts of MH into cryogel scaffolds, utilizing its properties in a sustained release fashion to assist in the overall healing process, while using the cryogel structure as a tissue template. All cryogels were evaluated to determine the effects of MH on porosity, swelling potential, mechanical durability, and cell compatibility. The release of MH was also quantified to evaluate bacterial clearance potential, and the scaffolds were mineralized to replicate native bone. It was determined that a 5% MH silk fibroin cryogel has the potential to inhibit bacterial growth while still maintaining adequate porosity, mechanical properties, and cell infiltration. Such a scaffold would have use in a number of applications, including bone regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1918-1933, 2018.

show abstract

“…Although this problem can be solved with plasticizers, such as glycerol, sucrose, and sorbitol, we used honey as a unique plasticizer, composed mainly of fructose, glucose, maltose, and sucrose, to improve the interactions between PVA and chitosan through the formation of hydrogen bonds through two networks. Moreover, not only is honey nontoxic and biocompatible but it also has remediation and healing properties . As a result, it can be a proper plasticizer for bioapplications, especially in wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of extremely biocompatible double‐network hydrogels based on chitosan and poly(vinyl alcohol) with enhanced mechanical properties

Pourjavadi

Tavakoli

Motamedi

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

An easy and ecofriendly method for designing double‐network (DN) hydrogels based on chitosan and poly(vinyl alcohol) (PVA) with high mechanical performance is described. When covalent bonds in the networks are used as crosslinking agents in the achievement of a higher mechanical strength, the irreversible deformation of these hydrogels after a large force is applied is still one of the most important obstacles. To overcome this problem, we used physical crosslinking for both networks. The mechanical strength, surface morphology, and cytotoxicity of the films were studied by tensile testing, scanning electron microscopy analysis, and an MTT assay. The synthesized chitosan–PVA DN hydrogels showed a large improvement in the tensile strength to 11.52 MPa with an elongation of 265.6%. The surface morphologies of the films demonstrated the effective interactions between the two networks and a suitable porosity. Also, because of the use of a natural polymer and honey as a plasticizer, the cell culture indicated that the synthesized DN hydrogels had good biocompatibility (with 327.49 ± 11.22% viability) and could be used as capable biomaterials. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45752.

show abstract

Manuka Honey: A Tissue Engineering Essential Ingredient

Cited by 19 publications

References 11 publications

Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair

Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair

A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds incorporated with Manuka honey for the treatment of chronic bone infections

Facile synthesis of extremely biocompatible double‐network hydrogels based on chitosan and poly(vinyl alcohol) with enhanced mechanical properties

Contact Info

Product

Resources

About