Manuka honey, a unique mono-floral honey. A comprehensive review of its bioactives, metabolism, action mechanisms, and therapeutic merits

El-Senduny, Fardous F.; Hegazi, Nesrine M.; El‐Ghani, Ghada E. Abd; Farag, Mohamed A.

doi:10.1016/j.fbio.2021.101038

Cited by 38 publications

(20 citation statements)

References 103 publications

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“…Oral administration of Manuka honey has also demonstrated antioxidant and anti‐inflammatory benefits on a systemic level, as well as chemoprotective effects. Oral intake of Manuka honey has also been shown to provide a potentiated antiviral response when taken in combination with the standard antiviral drugs zanamivir or oseltamivir 44 . Additionally, Manuka honey has been shown to possess potent inhibitory effects toward the influenza virus and the varicella‐zoster virus 45,46 .…”

Section: Current Uses and Methods Of Delivery For Manuka Honeymentioning

confidence: 99%

“…Oral intake of Manuka honey has also been shown to provide a potentiated antiviral response when taken in combination with the standard antiviral drugs zanamivir or oseltamivir. 44 Additionally, Manuka honey has been shown to possess potent inhibitory effects toward the influenza virus and the varicella-zoster virus. 45,46 Currently, the investigation is being done into Manuka honey as a potential treatment for SARS-CoV-2.…”

Section: Benefits Of Oral and Suppository Delivery Methodsmentioning

confidence: 99%

“…The research previously detailed indicates that Manuka honey not only prevents infection from viruses, bacteria, and fungal infections but is also a potent modulator of the immune response and prevents pathologies from an overactive immune reaction. 44 Localized delivery can reduce inflammation, while still being able to stave off infection. Hydrogels and impregnated dressings benefit and expedite resolution as wound dressings.…”

Section: Potential For Manuka Honey At Implantation and At The Host-b...mentioning

confidence: 99%

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Potential for Manuka honey‐inspired therapeutics to improve the host–biomaterial response

Main

Bowlin

2022

MedComm – Biomaterials and Applications

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Honey has been used by a wide variety of cultures across the world and for thousands of years to prevent infection and improve wound healing.Recently, Manuka honey has been demonstrated to be a potent antibacterial and anti-inflammatory therapeutic and has been incorporated into an array of wound dressings, as well as being ingested for its anti-inflammatory and antioxidant effects. Burgeoning investigation into Manuka honey's potential as a biomaterial additive has shown promising results in reducing acute inflammatory behavior from neutrophils, the most abundant leukocyte in the body, and the potent drivers of the initial immune response to implanted biomaterials. This paper discusses the most abundant antioxidant chemicals found in Manuka honey and explains their contribution to the anti-inflammatory and prowound resolution effects seen by Manuka honey therapeutics. This paper also examines the benefits and drawbacks to current Manuka honey therapies and provides future potential uses for Manuka honey-inspired therapeutics that could greatly benefit host-biomaterial integration, reduce scar tissue development at the site of implantation, and lower discomfort to the patient caused by biomaterial implantation.

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Section: Current Uses and Methods Of Delivery For Manuka Honeymentioning

confidence: 99%

Section: Benefits Of Oral and Suppository Delivery Methodsmentioning

confidence: 99%

Section: Potential For Manuka Honey At Implantation and At The Host-b...mentioning

confidence: 99%

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Potential for Manuka honey‐inspired therapeutics to improve the host–biomaterial response

Main

Bowlin

2022

MedComm – Biomaterials and Applications

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“…Sumber antioksidan pada madu dapat berupa antioksidan enzimatik dan antioksidan nonenzimatik. Antioksidan enzimatik pada madu diantaranya yaitu glucose oxidase, dan katalase, sedangkan antioksidan non enzimatik berupa senyawa metabolit sekunder seperti asam askorbat, senyawa fenolik, senyawa flavonoid, senyawa asam fenolik, senyawa turunan karotenoid, dan asam-asam organik (El-Senduny et al 2021). 2018).…”

Section: Pembahasanunclassified

Aktivitas Antioksidan, Total Fenolik, dan Total Flavonoid Madu Apis mellifera dari Hutan Akasia (Accacia crassicarpa) Riau, Indonesia dengan Beberapa Perlakuan Pengeringan

Handayani¹

2022

jbi

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Indonesian honey has high water content and often exceeds the limitation of standard quality appointed by national and international regulation. It is caused by the high humidity and the hygroscopic character of honey itself. Riau Province is one of the highest producers of honey, but the water content is high, about 23-27%. Heating can be used to decrease the water content, but it increases the risk of damage to honey’s secondary metabolites and may lose the functional character of honey towards human health. There is limited research that observes the effect of heating on honey’s secondary metabolites. Our research aimed to evaluate the effect of heating on Apis mellifera honey from acacia forest, Province of Riau, Indonesia towards the stability of honey’s secondary metabolites including water content analysis, screening of secondary metabolites, determination of antioxidant activity, measurement of TPC and TFC. The results show that the heating of 50 0C for 5 days and the heating of 1050C for 6 hours can decrease water content of honey without disturbing stability of honey’s secondary metabolites. It is showed by the score of IC50 of honey without heating (21103,74 μg/mL) is higher than the IC50 of honey heated by 500C (16503,83 μg/mL) and heated by 105 0C (777,33 μg/mL). The low value of IC50 indicates the high antioxidant activity, it is inline with TPC and TFC. The TPC and TFC without heating (TPC= 0,67 mgGAE/g; TFC=0,34 mgQE/g) is lower than sample heated by 500C (TPC=1,59 mgGAE/g; TFC=0,46 mgQE/g) and 1050C (TPC=13,94 mgGAE/g; TFC=4,37 mgQE/g).

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“…origin, honey is characterized by the botanical origin, searching to differentiate between floral or extra floral and among the floral, mono or multiflorals (10) (11) . Some honey such as Manuka honey has an added-value because it came from a native New Zealand myrtaceae (Leptospermum scoparium) and it is associated with medicinal properties (12) . Geographical origin (13) enables to avoid honey coming from contaminated regions as much as to ensure consumers that honey comes from natural or protected areas (5) .…”

Section: Introductionmentioning

confidence: 99%

Uruguayan honey from different regions, characterization and origin markers

et al. 2022

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Uruguay produces and exports honey. Honey is appreciated worldwide and has been well studied in terms of its chemical composition. These studies help determine botanical origin and prevent fraud. However, Uruguay exports honey without differentiating; the diversity of soils and vegetation in the country allows different types of honey production. Therefore, the aim of this work was to characterize honey from four regions of the country including three protected areas. The samples were collected during one year in two stations and electrical conductivity, humidity, sugar profile, macrominerals (K, Ca, Na and Mg) and pollen content were analyzed. The quality of the studied environments was evaluated by determining the presence of glyphosate. Results from this study confirm significant differences among the analyzed honeys from the different regions (Tukey-Kramer, p <0.05). Most of the measured values were within world ranges. However, some samples with high conductivity (> 0.8 mS / cm) associated with high mineral content were found. 37 different pollen taxa (family, genus or species) were detected. Some samples are monofloral (main pollen> 45%) of cultivated species (Lotus sp and Trifolium repens) or native species (Parkinsonia aculeata, Lithraea brasiliensis, Myrcianthes sp and Tripodanthus acutifolius). Calcium and sodium are suggested as markers of geographic origin. Mannose is suggested as a marker of botanical

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Manuka honey, a unique mono-floral honey. A comprehensive review of its bioactives, metabolism, action mechanisms, and therapeutic merits

Cited by 38 publications

References 103 publications

Potential for Manuka honey‐inspired therapeutics to improve the host–biomaterial response

Potential for Manuka honey‐inspired therapeutics to improve the host–biomaterial response

Aktivitas Antioksidan, Total Fenolik, dan Total Flavonoid Madu Apis mellifera dari Hutan Akasia (Accacia crassicarpa) Riau, Indonesia dengan Beberapa Perlakuan Pengeringan

Uruguayan honey from different regions, characterization and origin markers

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