Many respiratory viruses have temporal association with meningococcal disease

Castro-Rodriguez, José A.; Jakubson, Leticia; Padilla, Oslando; Gallegos, Doris; Fasce, Rodrigo; Bertrand, P.; Sánchez, Ignacio; Perret, Cecilia

doi:10.1016/j.aller.2014.07.005

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…It causes lysis of epithelial cells and other local immunologic damages, enhancing the invasiveness of pathogenic bacteria such as N. meningitidis. RSV has been shown not to affect or influence IMD, and other respiratory viruses have not consistently proven to enhance the invasiveness of N. meningitidis [11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 98%

“…Influenza infection has been previously associated with IMD, even triggering the latter [11,12]. However, other respiratory viruses, such as respiratory syncytial virus (RSV) and adenovirus, have either not or only suggestively been associated with IMD [13][14][15]. There is only one published case from Scotland of a young adult IMD patient co-infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in a good outcome [16].…”

Section: Introductionmentioning

confidence: 99%

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Fatal Pediatric Meningococcal Invasive Disease Caused by Neisseria meningitidis Serogroup C and Co-Infected With SARS-CoV-2: Report of a Case in Tijuana, Mexico

Chacón-Cruz¹,

Lopatynsky

Machado-Contreras

et al. 2022

Cureus

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Invasive meningococcal disease (IMD) is a severe infection caused by Neisseria meningitidis, with mortality rates ranging from 10% to 40%. IMD has been confirmed to be an endemic disease in Tijuana, Mexico, right across the border from San Diego, California. To date, coronavirus disease 2019 (COVID-19) is the most severe pandemic, causing more than 5.5 million deaths globally. Prior or co-infections of influenza with IMD has been reported previously; however, the participation of other respiratory viruses facilitating the invasiveness of N. meningitidis is either not shown or remains unclear. Here, we report the case of an unvaccinated (for IMD and COVID-19) seven-year-old child who had confirmed fatal IMD caused by N. meningitidis, serogroup C, and was co-infected by severe acute respiratory syndrome coronavirus 2.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Fatal Pediatric Meningococcal Invasive Disease Caused by Neisseria meningitidis Serogroup C and Co-Infected With SARS-CoV-2: Report of a Case in Tijuana, Mexico

Chacón-Cruz¹,

Lopatynsky

Machado-Contreras

et al. 2022

Cureus

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“…Studies conducted by J. A. Castro-Rodriguez et al in Chile [3] showed that many respiratory viruses like Respiratory syncytial virus, Influenza virus, Para influenza virus and adenovirus have temporal association with meningococcal disease. The case discussed here also gives a clinical history similar to flu like symptoms following which he developed severe respiratory infection.…”

Section: Discussionmentioning

confidence: 99%

Extended Spectrum Beta Lactamase (ESBL) Producing Neisseria meningitidis – Isolated from a Case of Pneumonia

Sasikumari

George

Devi

2021

EJMED

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Neisseria meningitidis (meningococci) is the most common cause of bacterial meningitis in all age groups. Invasive meningococcal disease manifesting as meningococcal pneumonia is a very rare clinical condition. Here we have a 72 year old male who presented with meningococcal pneumonia and sepsis following a flu like illness. It is notable that he did not develop the syndrome of meningococcemia or its associated complications. This patient was treated with injections of Piperacillin-Tazobactum and Azithromycin because of the unusual antibiotic resistance pattern of the organism. He recovered completely without any sequelae. The meningococci isolated was an ESBL (extended spectrum beta lactamase) producing strain, hence it was resistant to Penicillin and third generation Cephalosporins which are usually used for the treatment of meningococcal infections .This strain was also resistant to Ciprofloxacin .This poses a threat to the community as well, especially because Ciprofloxacin is used as a chemo prophylactic drug by the contacts of the patient and the laboratory workers dealing with the patient’s clinical samples.

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“…Some studies in symptomatic children have identified interferences between upper respiratory tract (URT) viruses and/or bacteria. 8,9,25,26 However, since these studies were performed in symptomatic populations they most likely represent interactions between true pathogens and not merely microorganisms in a carrier stage. The mechanisms underlying viral coexistence in case of asymptomatic patients are probably quite different, given the absence of activated inflammatory pathways, and so the results from the above studies should not be considered directly comparable to our own.…”

Section: Discussionmentioning

confidence: 99%

Evidence for respiratory viruses interactions in asymptomatic preschool-aged children

Douros

Kotzia

Kottaridi

et al. 2019

Allergologia et Immunopathologia

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Aim: To prospectively evaluate interferences between viruses of the upper respiratory tract in asymptomatic preschool children. Methods: Nasal-pharyngeal swabs from 233 preschool aged children were prospectively collected over four consecutive time periods, during one school year. The samples were tested using a RT-PCR DNA/RNA microarray system for nine respiratory viruses. Results: Respiratory syncytial virus (RSV) was a predictor of the presence of influenza virus (INFL) (OR: 9.12, CI: 1.52---54.75, p = 0.016), and similarly, INFL predicted the presence of RSV (OR: 4.01, CI: 1.14---14.16, p = 0.030). Also, rhinovirus (RV) was a predictor of adenovirus (ADV) presence (OR: 3.66, CI: 1.10---12.14, p = 0.034), and similarly, ADV predicted the presence of RV (OR: 4.05, CI: 1.02---16.05, p = 0.046). No other significant associations between viruses were observed. Conclusion: Our results indicate that respiratory viruses found in carrier stage in asymptomatic children may interact with other viruses and even facilitate their settling in the upper respiratory tract. The pathophysiological role of these interactions is not yet clear.

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Many respiratory viruses have temporal association with meningococcal disease

Abstract: The rate of MNG in Chile is temporally associated to all of the respiratory viruses studied, but with variability according age range, and regions.

Cited by 7 publications

References 19 publications

Fatal Pediatric Meningococcal Invasive Disease Caused by Neisseria meningitidis Serogroup C and Co-Infected With SARS-CoV-2: Report of a Case in Tijuana, Mexico

Fatal Pediatric Meningococcal Invasive Disease Caused by Neisseria meningitidis Serogroup C and Co-Infected With SARS-CoV-2: Report of a Case in Tijuana, Mexico

Extended Spectrum Beta Lactamase (ESBL) Producing Neisseria meningitidis – Isolated from a Case of Pneumonia

Evidence for respiratory viruses interactions in asymptomatic preschool-aged children

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