MAP3K1 variant causes hyperactivation of Wnt4/β-catenin/FOXL2 signaling contributing to 46,XY disorders/differences of sex development

H, Chen; Chen, Q; Zhu, Yan; K, Yuan; H, Li; Zhang, B; Zeng, Jia; Zhou, H; Fan, Ming; Qiu, Yong; Zhuang, Q; Zhang, Lei; M, Li; Huang, W; Liang, L; Qiu, Yan; C, Wang

doi:10.1530/ey.19.6.7

Cited by 146 publications

(196 citation statements)

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“…This finding at the same time rejects the hypothesis of growth led export in sort run. In addition, Hye and Boubaker (2011) found the same finding in Tunisia. This various finding of study means there is gaps empirically in export and growth relationship.…”

Section: Introductionsupporting

confidence: 66%

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The correlation of international trade and growth in Indonesia

Sudarmawan

2023

JEP

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Exports generate foreign exchange that can be used for economic activities. On the other hand, imports also give households and companies more choices in consuming goods. In other words, international trade provides advantages for each country. There have been many studies that attempt to empirically prove the relationship between export-import and economic growth. The aim of this study is to re-examine the relationship between exports, imports, and growth in the short run and long run in Indonesia. This study employed the Granger Causality test and VECM to find long-term and short-term respectively. This research used secondary data annually from 1980 to 2019. Result of this empirical study, we find correlating variables are GDP-Exports, GDP-Imports, and Imports-Exports in the long-term. These three long-term findings match the short-term findings explained by VECM modeling. According to these findings, the policy recommendation is Indonesia needs to import carefully because importing consumption goods is a sure way to deplete its own foreign exchange reserves. Second, based on our empirical found, importing intermediate goods can increase our export, so we suggest Indonesia should run substitution import strategy immediately

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Section: Introductionsupporting

confidence: 66%

“…However, previous study conducted by Ali et al (2017) Hye (2012, Ashraf et al (2011), andHye andBoubaker (2011) found bidirectional between import and growth, consist of import led growth and growth led import. Therefore, previous study cannot explain the relationship between import and growth in the short run and long run.…”

Section: Introductionmentioning

confidence: 84%

The correlation of international trade and growth in Indonesia

Sudarmawan

2023

JEP

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“…FOXL2 has an important role in sex determination and differentiation, ovarian development and maintenance, embryonic development, and immune regulation in animals (He et al, 2020;Craig et al, 2005). Sequence analysis of the CsFOXL2 in the present study showed that CsFOXL2 contains an FH domain.…”

mentioning

confidence: 48%

Characterization, expression profiling, and estradiol response analysis of DMRT3 and FOXL2 in clam Cyclina sinensis

Yan¹,

Xu²,

Xie³

et al. 2023

Front. Mar. Sci.

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The clam Cyclina sinensis is one of the important economical aquaculture shellfish in China. However, the mechanisms of sex determination and differentiation in C. sinensis have not been fully studied. In this study, full-length cDNAs of DMRT3 and FOXL2 were cloned and functionally characterized. The ORF region of CsDMRT3 consists of 1137 nucleotides, which encode 378 amino acids contains a conserved DM domain of DMRT family. The ORF region of CsFOXL2 is 1245 bp, encodes 414 amino acids, and contains a conserved FH domain. Tissue-specific expression results showed that the higher expression level of CsDMRT3 and CsFOXL2 was found in the ovary and testis of C. sinensis. The expression levels of CsDMRT3 and CsFOXL2 also peaked at the maturation stage of male and female gonadal development, respectively. Moreover, the expression levels of CsDMRT3 and CsFOXL2 were significantly higher in the trochophore and D-larval stages than in other stages. The transcript levels of CsDMRT3 reached the highest level at 11 months of age, while the CsFOXL2 reached the highest level at 7 months of age. In estradiol-treated experiments, the expression levels of CsDMRT3 and CsFOXL2 in the gonads were highest at 5 µg/L estradiol treatment, and histologically, it was observed that the oocytes diameters became larger with increasing estradiol concentration. These results suggest that CsDMRT3 and CsFOXL2 play an important role in gonadal development and sex differentiation of C. sinensis.

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“…By activating the PPARγ/LXRα/ABCA1 signaling pathway, emodin boosted ApoA-1-mediated cholesterol efflux from THP-1 macrophages. Emodin also reduced diet-induced AS in rabbits (Hei et al, 2006;Fu et al, 2014).…”

Section: Emodinmentioning

confidence: 84%

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Wang

Liu²,

Hu³

et al. 2023

Front. Pharmacol.

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Atherosclerosis (AS) is the pathology of atherosclerotic cardiovascular diseases (ASCVD), characterized by persistent chronic inflammation in the vessel wall, in which monocytes/macrophages play a key role. It has been reported that innate immune system cells can assume a persistent proinflammatory state after short stimulation with endogenous atherogenic stimuli. The pathogenesis of AS can be influenced by this persistent hyperactivation of the innate immune system, which is termed trained immunity. Trained immunity has also been implicated as a key pathological mechanism, leading to persistent chronic inflammation in AS. Trained immunity is mediated via epigenetic and metabolic reprogramming and occurs in mature innate immune cells and their bone marrow progenitors. Natural products are promising candidates for novel pharmacological agents that can be used to prevent or treat cardiovascular diseases (CVD). A variety of natural products and agents exhibiting antiatherosclerotic abilities have been reported to potentially interfere with the pharmacological targets of trained immunity. This review describes in as much detail as possible the mechanisms involved in trained immunity and how phytochemicals of this process inhibit AS by affecting trained monocytes/macrophages.

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MAP3K1 variant causes hyperactivation of Wnt4/β-catenin/FOXL2 signaling contributing to 46,XY disorders/differences of sex development

Cited by 146 publications

References 0 publications

The correlation of international trade and growth in Indonesia

The correlation of international trade and growth in Indonesia

Characterization, expression profiling, and estradiol response analysis of DMRT3 and FOXL2 in clam Cyclina sinensis

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

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