MAPK/ERK signal pathway alterations in patients with Langerhans Cell Histiocytosis

Novosad, O.; Skrypets, Tetiana; Pastushenko, Y.; Titorenko, I.; Martynchyk, A.; Skachkova, O.; Inomistova, M.; Gorbach, Oleksandr; Khranovska, N.; Kryachok, Irina

doi:10.14735/amko2018130

Klin Onkol

2018

DOI: 10.14735/amko2018130

|View full text |Cite

MAPK/ERK signal pathway alterations in patients with Langerhans Cell Histiocytosis

O. Novosad¹,

Tetiana Skrypets²,

Y. Pastushenko³

et al.

Abstract: BRAF and NRAS mutations in LCH suggest a possibility of the disease being driven by the activation of the MAPK/ERK pathway. These oncogenic mutations provide new opportunities in understanding LCH pathogenesis and may be a potential target of therapy.Key words: Langerhans cell histiocytosis - mutations - prognostic factors - relapse - survival.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Comparison of recent WHO classification published 2017 and classification of Histiocyte Society published 2016

Král¹,

Adam²,

Ježová³

et al. 2020

Vnitř Lék

View full text Add to dashboard Cite

Interní hematoonkologická klinika LF MU a FN Brno, pracoviště Bohunice 2 Ústav patologie LF MU a FN Brno, pracoviště Bohunice Neoplazie z histiocytárních a dendritických buněk jsou velmi raritní, a tedy obtížně diagnostikovalné nemoci. Nejčastější z nich je histiocytóza z Langerhansových buněk, incidence ostatních nemocí je ještě menší. V následujícím přehledu je shrnuta jejich charakteristika a uvedeny recentní klasifikace, standardně používaná WHO klasifikace (poslední verze publikovaná v roce 2017) a paralelně s ní existující klasifikace, vytvořená společností Histiocyte Society (poslední verze publikovaná v roce 2016).Klíčová slova: neoplazie odvozené od histiocytárních a dendritických buněk. Histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Comparison of recent WHO classification published 2017 and classification of Histiocyte Society published 2016The histiocytoses are rare disorders characterized by the accumulation of cells thought to be derived from dendritic cells or macrophages. Their clinical behaviour ranges from mild to disseminated and, sometimes, life-threatening forms. The incidence of this diseases is much smaller, then the incidence of diseases derived from lymphocytic or myeloid lineage. Langerhans cell histiocytosis is most frequent disease from this group. The last version of WHO classification from 2017 and last version of classification published by Histiocyte Society is summarised in this paper.

show abstract

Histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Comparison of recent WHO classification published 2017 and classification of Histiocyte Society published 2016

Král¹,

Adam²,

Ježová³

et al. 2020

Vnitř Lék

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

MAPK/ERK signal pathway alterations in patients with Langerhans Cell Histiocytosis

Cited by 1 publication

References 16 publications

Histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Comparison of recent WHO classification published 2017 and classification of Histiocyte Society published 2016

Histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Comparison of recent WHO classification published 2017 and classification of Histiocyte Society published 2016

Contact Info

Product

Resources

About