Mapping and Developmental Expression Analysis of the WD-Repeat Gene Preb

Clelland, Catherine L.; Craciun, Liviu C; Bancroft, Carter; Lufkin, Thomas

doi:10.1006/geno.1999.6089

Cited by 12 publications

(9 citation statements)

References 44 publications

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“…The subsequent window of BTA11 (72-73Mb) harbors important genes previously reported to be associated with reproductive events, such as SLC30A3 [30] and CAD [31] described as estrogen receptors, CIB4 associated with male sheep fecundity [32], EMILIN1 associated with placentation and trophoblast invasion in the uterine wall [33], TCF23 which plays an important role in endometrial decidualization [34], UCN associated with steroidogenesis and maintenance of placental function which is expressed in mature mouse spermatozoa and rat epididymis [35, 36, 37], and IFT172 , PREB and SNX17 which are associated with neural development [38, 39, 40, 41]. Furthermore, window 49-50Mb of BTA17 has been reported to be associated with age at first calving in Nellore cows [13].…”

Section: Resultsmentioning

confidence: 99%

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Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

et al. 2017

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Reproductive traits are economically important for beef cattle production; however, these traits are still a bottleneck in indicine cattle since these animals typically reach puberty at older ages when compared to taurine breeds. In addition, reproductive traits are complex phenotypes, i.e., they are controlled by both the environment and many small-effect genes involved in different pathways. In this study, we conducted genome-wide association study (GWAS) and functional analyses to identify important genes and pathways associated with heifer rebreeding (HR) and with the number of calvings at 53 months of age (NC53) in Nellore cows. A total of 142,878 and 244,311 phenotypes for HR and NC53, respectively, and 2,925 animals genotyped with the Illumina Bovine HD panel (Illumina®, San Diego, CA, USA) were used in GWAS applying the weighted single-step GBLUP (WssGBLUP) method. Several genes associated with reproductive events were detected in the 20 most important 1Mb windows for both traits. Significant pathways for HR and NC53 were associated with lipid metabolism and immune processes, respectively. MHC class II genes, detected on chromosome 23 (window 25-26Mb) for NC53, were significantly associated with pregnancy success of Nellore cows. These genes have been proved previously to be associated with reproductive traits such as mate choice in other breeds and species. Our results suggest that genes associated with the reproductive traits HR and NC53 may be involved in embryo development in mammalian species. Furthermore, some genes associated with mate choice may affect pregnancy success in Nellore cattle.

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Section: Resultsmentioning

confidence: 99%

“…Some genes ( SLIT1 , TNR , FAM181B , IFT172 , PPM1G , SNX17 , and PREB ) associated with neural development [38, 39, 40, 41, 58, 59, 60, 61, 62, 63] were also found in the top 20 significant windows for both traits. Costa et al [10] also detected genes related to neural development that were associated with reproductive traits.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

et al. 2017

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“…Leucine-19 is conserved in mouse, rat and Caenorhabditis elegans Sec12/PREB proteins. The mouse Sec12/PREB cDNA sequence has been previously reported [26]. However, the ORF reported here differs by the inclusion of an inserted glycine-136 residue.…”

Section: Resultsmentioning

confidence: 93%

“…In the mouse, the presence of antisense transcripts of the lung alpha/beta hydrolase-1 ( ABHD1 )[25] and prolactin regulatory element binding ( Sec12/PREB ) genes [26] has been identified by a computational search [3]. Recently, we cloned three closely related cDNAs from a murine lung cDNA library [25], the open reading frames (ORF) of which contained a predicted alpha/beta hydrolase domain [27], containing a catalytic triad analogous to that present in serine proteases, leading them to be named lung alpha/beta hydrolase (LABH1-3) fold proteins.…”

Section: Introductionmentioning

confidence: 99%

“…A recombinant part of rat Sec12, encompassing residues 175–417, has been reported as the prolactin regulatory element binding protein (PREB) transcription factor which regulates the activity of the prolactin promoter [29]. The murine PREB gene has been localised to the proximal end of chromosome 5 [26] and a partial human cDNA encoding PREB was cloned from brain and mapped to 2p23 [34]. Overall, Sec12/PREB transcripts are highly abundant in tissues that are active in secretion [29].…”

Section: Introductionmentioning

confidence: 99%

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The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12

Edgar

2003

BMC Genomics

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Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome

et al. 2000

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We have isolated the human homolog of a novel rodent gene that may be involved in the regulation of pituitary gene transcription. The human PREB gene encodes a predicted protein of 417 amino acids, exhibiting several sequences characteristic of the WD-motif protein family. PREB transcripts were detected in every human fetal and adult tissue examined, although a great variation in levels of expression was observed. PREB was mapped to human Chromosome 2p23, a region of the genome associated with partial trisomy 2p syndrome. Although variable, the common duplication phenotype includes facial abnormalities, skeletal defects, growth and mental retardation, congenital heart and neural tube defects, and abnormalities of the genitalia. We propose that PREB has a role during human development and that abnormal dosage of this transcription factor may be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p.

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Mapping and Developmental Expression Analysis of the WD-Repeat Gene Preb

Cited by 12 publications

References 44 publications

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12

Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome

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