Abstract. Clinical Decision Support Systems (CDSS) have gained relevance due to their potential to support patient-centric care, but their deployment still has to overcome barriers to become successful. One of these barriers is the integration of patient data with the CDSS engine, a tough challenge given the need to address interoperability with many different existing systems and medical devices. The MobiGuide project aims to build such a CDSS, providing guideline-based clinical decision support through a Personal Health Record (PHR). This PHR is the main component through which the CDSS could access patient data originating from hospital EMRs and wearable sensors, but it also contains the log of the recommendations provided by the CDSS. Using a case study, we compare data-representation standards through which the PHR could be developed, while considering expressiveness and usability requirements. We propose to develop the PHR by combining openEHR archetypes and the HL7 Virtual Medical Record standard, supported by a service oriented framework for data exchange. This proposal aims to close the gap between the HL7 and the ISO/CEN 13606 by using an openEHR-based approach.