Background.
Inappropriate sinus tachycardia (IST) is a rare clinical disorder
characterized by an elevated resting heart rate and an exaggerated rate
response to exercise or autonomic stress. Pharmacologic therapy and catheter
ablation are considered first-line treatments for IST but can yield
suboptimal relief of symptoms. The results of surgical ablation at our
center were reviewed for patients with refractory IST.
Methods.
Between 1987 and 2018, 18 patients underwent surgical sinoatrial (SA)
node isolation for treatment-refractory IST. All 18 patients had previously
failed pharmacologic therapy, and 15 patients had failed catheter ablation
of the SA node.
Results.
Ten patients underwent a median sternotomy, and 8 patients underwent
a minimally invasive right thoracotomy. The SA node was isolated with the
use of surgical incisions, cryoablation, or bipolar radiofrequency
ablations. Sinus tachycardia was eliminated in 100% of patients in the
immediate postoperative period. Long-term follow-up data were available for
17 patients, with a mean follow-up of 11.4 ± 7.9 years. At last
follow-up, 100% of patients were free from recurrent symptomatic IST. More
than 80% of patients were completely asymptomatic, whereas 3 patients
reported occasional palpitations. Four patients were on b-blockers, and 5
patients required subsequent pacemaker implantation. All 8 patients who
underwent minimally invasive isolation were in normal sinus rhythm at last
follow-up, and only 1 patient complained of palpitations.
Conclusions.
Surgical isolation of the SA node is a feasible treatment for IST
refractory to pharmacologic therapy and catheter ablation. A minimally
invasive surgical approach offers a less morbid alternative to traditional
median sternotomy.