Mappingin silicogenetic networks of theKMT2Dtumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities
Yuka Takemon,
Erin D. Pleasance,
Alessia Gagliardi
et al.
Abstract:Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required. Here, we computationally map genetic networks ofKMT2D, a tumour suppressor gene frequently mutated in several cancer types. UsingKMT2Dloss-of-function (KMT2DLOF) mutations as a model, we illustrate the utility ofin silicogenetic networks in uncovering novel functional associations and vulnerabilities in cancer cells with… Show more
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