Mapping micromechanical properties of soft polymer contact lenses

Chyasnavichyus, Marius; Young, Seth L.; Tsukruk, Vladimir V.

doi:10.1016/j.polymer.2014.09.053

Cited by 23 publications

(20 citation statements)

References 51 publications

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“…Thin and soft materials might experience a substrate‐backing effect on the specification of the films elasticity, mainly when the indentation depth goes beyond 10% of the CL thickness . Hence, other methods have been used to assess the compression properties of lenses, like atomic force microscopy, the falling dart method, and micro‐shaft poking …”

Section: Mechanical Behavior Of Contact Lensesmentioning

confidence: 99%

Recent Trends in Advanced Contact Lenses

Mutlu

Es‐haghi

Çakmak

2019

Adv Healthcare Materials

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Exploiting contact lenses for ocular drug delivery is an emerging field in the area of biomedical engineering and advanced healthcare materials. Despite all the research conducted in this area, still, new technologies are in their early stages of the development, and more work must be done in terms of clinical trials to commercialize these technologies. A great challenge in using contact lenses for drug delivery is to achieve a prolonged drug release profile within the therapeutic range for various eye‐related problems and diseases. In general, desired release kinetics to avoid the initial burst release is the zero‐order kinetics within the therapeutic range. This review highlights the new technologies developed to achieve efficient and extended drug delivery. It also provides an overview of the materials and methods for fabrication of contact lenses and their mechanical and optical properties.

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Section: Mechanical Behavior Of Contact Lensesmentioning

confidence: 99%

Recent Trends in Advanced Contact Lenses

Mutlu

Es‐haghi

Çakmak

2019

Adv Healthcare Materials

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“…The lens was measured immediately after removal from the original blister pack containing saline solution and discarded after one day of measurements. The lens was sectioned as described in detail in an earlier study in order to create a flat region conducive to AFM measurements [15]. A small droplet of the saline solution taken from the blister pack was placed at the scanning surface of the lens and measurements with the AFM were made inside of this droplet.…”

Section: Methodsmentioning

confidence: 99%

“…The versatility of AFM facilitates the measurement of surface forces in controlled environments, as well as with a variety of tip shapes and cantilever spring constants [13,14]. These methods have been successfully employed in our laboratory to study the micromechanical behavior of thin and ultra-thin polymer films [1], silicone-based contact lenses [15], biological sensing systems [16], and cell encapsulation membranes [17] to name a few. However, experimental routines as well as data analysis for the consistent extraction of accurate, quantitative data is not always a straight forward process.…”

Section: Introductionmentioning

confidence: 99%

Probing elastic properties of soft materials with AFM: Data analysis for different tip geometries

Chyasnavichyus

Young

Geryak

et al. 2016

Polymer

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It has become increasingly common to use atomic force microscopy measurements to probe mechanical properties at the nano-micro level. The data obtained from these measurements, however, must be subjected to specific models for deconvolution of the effect of the probe's tip size and shape. While analytical models have been developed to assist in this endeavor, a thorough understanding of the limits of these models is essential to fitting data accurately. In this report, we explore the relationship between three different analytical tip shape models for the AFM tip (spherical, parabolic, and conical indenters) and present an analysis of mechanical testing on selected materials. Along with this, we present a simple numerical method for computing the contact radius for true spherical contact. The role of tip size (large vs small radius) on the limitations of data analysis and the benefits and drawbacks inherent to different tip sizes is discussed. Our analysis demonstrates the ability to accurately apply multiple models to a given data set, while also showing the limitations of simple analytical models to accurately describe tip-sample interactions outside of certain indentation regimes.

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“…With this method (commercially known as the peak force tapping mode), as the z-piezoelement raster scans the surface, it also resonates at very high frequencies. During each resonance cycle, the tip engages the surface and then is retraced from it at a given amplitude; thereby, hundreds of FDCs can be produced in matter of milliseconds [155,156]. This AFM mode has gained increased popularity in the field of surface characterization of biological materials [157,158].…”

Section: Nanoscale Adhesion On Viscoelastic Surfacesmentioning

confidence: 99%

Multiscale Frictional Properties of Cotton Fibers: A Review

Hosseinali

Thomasson

2018

Fibers

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This review discusses the important concept of cotton fiber friction at both the macro-and nanoscale. First, the technological importance of fiber friction and its role in fiber breakage during fiber processing is discussed. Next, previous studies on frictional properties of cotton fibers are reviewed and different experimental procedures to measure friction between fibers or against another surface are evaluated. Friction models developed to explain friction process during various experimental procedures are considered and their limitations are discussed. Since interpretation of friction processes at the macroscale can be challenging (mainly due to difficulties in analyzing the multiple asperities in contact), a separate section is devoted to surveying studies on the emerging field of single-asperity friction experiments with atomic force microscope (AFM). Special attention is given to studies on nanoscale frictional characteristics of rough viscoelastic surfaces (e.g., plant cuticular biopolymers and cotton fibers). Due to the close relationship between friction and adhesion hysteresis at the nanoscale, adhesion studies with AFM on viscoelastic surfaces are also reviewed. Lastly, recommendations are made for future research in the field of frictional properties of cotton fibers.

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Mapping micromechanical properties of soft polymer contact lenses

Cited by 23 publications

References 51 publications

Recent Trends in Advanced Contact Lenses

Recent Trends in Advanced Contact Lenses

Probing elastic properties of soft materials with AFM: Data analysis for different tip geometries

Multiscale Frictional Properties of Cotton Fibers: A Review

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