Mapping motion from 4D‐MRI to 3D‐CT for use in 4D dose calculations: A technical feasibility study

Boye, Dirk; Lomax, Tony; Knopf, Antje

doi:10.1118/1.4801914

Cited by 103 publications

(137 citation statements)

References 57 publications

Supporting

Mentioning

137

Contrasting

Order By: Relevance

“…A possible solution was proposed by Boye et al to get motion information from 4D magnetic resonance imaging (4DMRI) and use it in 4D dose calculations [Boye et al, 2013].…”

Section: Study Limitationsmentioning

confidence: 99%

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

et al. 2016

View full text Add to dashboard Cite

Stereotactic body image guided radiation therapy (SBRT) shows excellent results for the local control of early stage lung cancer. However, not all patients are eligible for SBRT, and advanced stage treatment is less successful and often associated with severe side effects. Scanned carbon ion therapy (PT) can deliver more conformal dose likely benefiting these patient groups.Therefore an in silico trial was conducted on early and advanced stage patients to identify potential advantages of PT. The patients were treated with SBRT at Champalimaud Center for the Unknown, Lisbon (Portugal). PT plans were simulated on 4DCTs, and rescanning was investigated for motion mitigation in 4D-dose calculations. A dedicated strategy for 4D intensity modulated particle therapy (IMPT) was developed and applied for advanced stage patients with multiple lesions. For clinically valid and reliable results the deformable image registrationnecessary for 4D-dose calculation -a quality assurance tool was developed and applied in the study.The results showed that target coverage was comparable in SBRT and PT, while PT delivered significantly lower doses to most critical structures, especially the heart, lungs, and esophagus.A highly complex case of advanced stage lung cancer could be treated in a single fraction of 24 Gy with PT, while SBRT could not deliver the full ablative dose treatment due to an excessive heart dose. The mean heart dose was reduced from 10 Gy to 0.8 Gy with PT for this specific patient.

show abstract

“…A possible solution was proposed by Boye et al to get motion information from 4D magnetic resonance imaging (4DMRI) and use it in 4D dose calculations [Boye et al, 2013].…”

Section: Study Limitationsmentioning

confidence: 99%

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The virtual CT method, including interfraction compensation, performed well even in this case, exhibiting a geometrical accuracy within the voxel size and Dose Volume Histograms deviations up to 3.3% for target V 95% (mean dose difference ≤ 0.2% of the prescription dose, gamma pass rate > 98%). Conversely, significant errors were found when omitting the compensation of non‐rigid inter‐fraction changes by means of multimodal DIR, with discrepancies on tumor D 95% and V 95% larger than 10%, demonstrating the better accuracy and effectiveness of the implemented approach with respect to the literature method . The CoMBAT phantom has been already reported in the literature for validation purposes in the field of MRI‐guidance.…”

Section: Discussionmentioning

confidence: 96%

“…Two experiments were performed: (a) the virtual 4DCT was generated considering the simulated 4DMRI and the reference 3D CT, as described in Section 2.A; (b) the virtual 4DCT was obtained without performing the DIR between the end‐exhale MRI and the reference CT, thus neglecting inter‐fraction variations of anatomo‐pathological structures …”

Section: Methodsmentioning

confidence: 99%

Virtual 4DCT from 4DMRI for the management of respiratory motion in carbon ion therapy of abdominal tumors

et al. 2020

View full text Add to dashboard Cite

Purpose To evaluate a method for generating virtual four‐dimensional computed tomography (4DCT) from four‐dimensional magnetic resonance imaging (4DMRI) data in carbon ion radiotherapy with pencil beam scanning for abdominal tumors. Methods Deformable image registration is used to: (a) register each respiratory phase of the 4DMRI to the end‐exhale MRI; (b) register the reference end‐exhale CT to the end‐exhale MRI volume; (c) generate the virtual 4DCT by warping the registered CT according to the obtained deformation fields. A respiratory‐gated carbon ion treatment plan is optimized on the planning 4DCT and the corresponding dose distribution is recalculated on the virtual 4DCT. The method was validated on a digital anthropomorphic phantom and tested on eight patients (18 acquisitions). For the phantom, a ground truth dataset was available to assess the method performances from the geometrical and dosimetric standpoints. For the patients, the virtual 4DCT was compared with the planning 4DCT. Results In the phantom, the method exhibits a geometrical accuracy within the voxel size and Dose Volume Histograms deviations up to 3.3% for target V95% (mean dose difference ≤ 0.2% of the prescription dose, gamma pass rate > 98%). For patients, the virtual and the planning 4DCTs show good agreement at end‐exhale (3% median D95% difference), whereas other respiratory phases exhibit moderate motion variability with consequent dose discrepancies, confirming the need for motion mitigation strategies during treatment. Conclusions The virtual 4DCT approach is feasible to evaluate treatment plan robustness against intra‐ and interfraction motion in carbon ion therapy delivered at the abdominal site.

show abstract

“…Faced with the complexities of 4D treatment, standard dose‐calculation engines found in treatment planning systems (TPSs) that only consider dose to a static three‐dimensional (3D) geometry are insufficient to fully describe the expected dose distribution for cases with tumor/organ motion; a 4D‐dose calculator (4DDC) is thus necessary . Although some TPSs offer methods to compute 4D dose, these offerings are nonideal for several reasons.…”

Section: Introductionmentioning

confidence: 99%

A Monte‐Carlo‐based and GPU‐accelerated 4D‐dose calculator for a pencil beam scanning proton therapy system

et al. 2018

View full text Add to dashboard Cite

show abstract

Mapping motion from 4D‐MRI to 3D‐CT for use in 4D dose calculations: A technical feasibility study

Abstract: The authors have demonstrated that motion information from 4D-MRI can be used to generate realistic 4D-CT data sets on the basis of a single static 3D-CT data set. 4D-CT(MRI) presents a novel approach to test the robustness of treatment plans in the circumstance of patient motion.

Cited by 103 publications

References 57 publications

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

Virtual 4DCT from 4DMRI for the management of respiratory motion in carbon ion therapy of abdominal tumors

A Monte‐Carlo‐based and GPU‐accelerated 4D‐dose calculator for a pencil beam scanning proton therapy system

Contact Info

Product

Resources

About