Mapping Myocardial Salvage Index by Extracellular Volume Fraction

Bulluck, Heerajnarain; Hausenloy, Derek J.

doi:10.1161/circimaging.117.006680

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…However, Bland-Altman analysis showed a bias of 1.9% and wide limits of agreement of ±10.5% and further studies are therefore needed to build on these findings. 47 However, as it stands, ECV-mapping may complement late gadolinium enhancement imaging to assess MI size and predict wall motion recovery at follow-up, as recently shown by 2 small studies. 16, 48 …”

Section: Recent Advances In the Role Of Cmr In Reperfused Stemi Patientsmentioning

confidence: 94%

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

et al. 2018

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While mortality following ST-segment elevation myocardial infarction (STEMI) is on the decline, the number of patients developing heart failure due to prior myocardial infarction (MI) is on the rise. Apart from timely reperfusion by primary percutaneous coronary intervention (PPCI), there is currently no established therapy for reducing MI size. As such new cardioprotective therapies are required to improve clinical outcomes following STEMI. Cardiovascular magnetic resonance (CMR) has emerged as an important imaging modality for assessing the efficacy of novel therapies for reducing MI size and preventing subsequent adverse left ventricular remodeling. The recent availability of multi-parametric mapping CMR has provided new insights into the pathophysiology underlying myocardial edema, microvascular obstruction, intramyocardial hemorrhage, and changes in the remote myocardial interstitial space following STEMI. In this article, we provide an overview of the recent advances in CMR imaging in reperfused STEMI patients, discuss the controversies surrounding its use, and explore future applications of CMR in this setting.

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Section: Recent Advances In the Role Of Cmr In Reperfused Stemi Patientsmentioning

confidence: 94%

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

et al. 2018

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“…38 showed that ECV maps could be used for the AAR and chronic MI size by applying different thresholds. However, the limits of agreement with the T2-derived AAR from the T2-weighted imaging were quite wide at ±10.4% 39 . Whether the wide limits of agreement in edema measures seen in the study by Garg et al .…”

Section: Discussionmentioning

confidence: 92%

“…Whether the wide limits of agreement in edema measures seen in the study by Garg et al . 39 could be due to ECV not identifying the edema-based AAR accurately in some patients with less severe extracellular edema, warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Interrogation of the infarcted and salvaged myocardium using multi-parametric mapping cardiovascular magnetic resonance in reperfused ST-segment elevation myocardial infarction patients

Hausenloy

Lim

Chan

et al. 2019

Sci Rep

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We used multi-parametric cardiovascular magnetic resonance (CMR) mapping to interrogate the myocardium following ST-segment elevation myocardial infarction (STEMI). Forty-eight STEMI patients underwent CMR at 4 ± 2 days. One matching short-axis slice of native T1 map, T2 map, late gadolinium enhancement (LGE), and automated extracellular volume fraction (ECV) maps per patient were analyzed. Manual regions-of-interest were drawn within the infarcted, the salvaged and the remote myocardium. A subgroup analysis was performed in those without MVO and with ≤75% transmural extent of infarct. For the whole cohort, T1, T2 and ECV in both the infarcted and the salvaged myocardium were significantly higher than in the remote myocardium. T1 and T2 could not differentiate between the salvaged and the infarcted myocardium, but ECV was significantly higher in the latter. In the subgroup analysis of 15 patients, similar findings were observed for T1 and T2. However, there was only a trend towards ECV salvage being higher than ECV remote . In the clinical setting, current native T1 and T2 methods with the specific voxel sizes at 1.5 T could not differentiate between the infarcted and salvaged myocardium, whereas ECV could differentiate between the two. ECV was also higher in the salvaged myocardium when compared to the remote myocardium.

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Relaxometry: Applications in the Heart

Dall’Armellina

Das

2020

Advances in Magnetic Resonance Technology and Applications

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Mapping Myocardial Salvage Index by Extracellular Volume Fraction

Cited by 3 publications

References 21 publications

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

Interrogation of the infarcted and salvaged myocardium using multi-parametric mapping cardiovascular magnetic resonance in reperfused ST-segment elevation myocardial infarction patients

Relaxometry: Applications in the Heart

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