Mapping of the Gene for the Mouse Telomerase RNA Component,Terc,to Chromosome 3 by Fluorescencein SituHybridization and Mouse Chromosome Painting

Ai, Soder; Hoare, SF; Muire, S; Balmain, Allan; Ek, Parkinson; Keith, W. Nicol

doi:10.1006/geno.1997.4621

Cited by 18 publications

(7 citation statements)

References 6 publications

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“…The 3q26‐29 amplicon is spread over four major cytogenetic bands with 10 subdivisions, and contains 188 protein‐encoding genes with associated TCGA genomic data: 62% of these genes also have increased gene expression ( z ‐score > 2 in > 10% patients, E. J. Shanks, M. A. Davidson & M. Neilson, unpublished results) . Figure provides current genomic alteration data (copy number amplification, mRNA upregulation and mutation status) for genes known to arbitrate key oncogenic driver events in HNSCC, including PIK3CA (which encodes the p110 catalytic subunit of PI3K) and TERC, the telomerase RNA component gene , as well as novel genes revealed in our analysis. However, it is unlikely that all of the genes within the amplicon will be relevant to disease, thus necessitating the implementation of other characteristics such as survival and mutation status.…”

Section: Identification Of Pro‐oncogenic Factors In 3q26‐29mentioning

confidence: 99%

3q26‐29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes

Davidson

Shanks

2017

The FEBS Journal

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Head and neck squamous cell carcinoma (HNSCC) is significantly underrepresented in worldwide cancer research, yet survival rates for the disease have remained static for over 50 years. Distant metastasis is often present at the time of diagnosis, and is the primary cause of death in cancer patients. In the absence of routine effective targeted therapies, the standard of care treatment remains chemoradiation in combination with (often disfiguring) surgery. A defining characteristic of HNSCC is the amplification of a region of chromosome 3 (3q26‐29), which is consistently associated with poorer patient outcome. This review provides an overview of the role the 3q26‐29 region plays in HNSCC, in terms of both known and as yet undiscovered processes, which may have potential clinical relevance.

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Section: Identification Of Pro‐oncogenic Factors In 3q26‐29mentioning

confidence: 99%

3q26‐29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes

Davidson

Shanks

2017

The FEBS Journal

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“…34,35 Several studies based on this approach and using CGH data have also been documented. 31,36,37 Clustering of aberrations between SK and SCC demonstrates a dispersion of SK samples among the SCC population. If SK were a dysplasia distinct from SCC, most samples would cluster into a separate subset.…”

Section: Commentmentioning

confidence: 99%

“…The gain of 3q may be linked to the human telomerase RNA gene, which maps to this arm. 37 Aberrant telomerase activity has been linked to cellular immortality and tumor progression in a wide array of tumor types, including nonmelanoma skin cancer, and in many of these types overexpression of the 3q arm can be observed. [38][39][40] Interestingly, the loss of 3p and gain of 3q was a significant occurrence in SCC.…”

Section: Commentmentioning

confidence: 99%

Chromosomal Aberrations in Squamous Cell Carcinoma and Solar Keratoses Revealed by Comparative Genomic Hybridization

Ashton¹,

Weinstein²,

Maguire³

et al. 2003

Arch Dermatol

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“…The gene encoding hTR was cloned in 1995 [120]. It is a single copy gene localized to chromosome 3 at 3q26.3 by fluorescence in situ hybridization [121]. The half-life of this RNA, transcribed in mammals by RNA polymerase II, varies from 4 to 32 days [122], and thus is the longest ever reported for an eukaryotic RNA.…”

Section: Htr (Human Telomerase Rna)mentioning

confidence: 99%

Telomeres and Telomerase: Pharmacological Targets for New Anticancer Strategies?

Pendino

Tárkányi

Dudognon

et al. 2006

CCDT

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Telomeres are located at the ends of eukaryotic chromosomes. Human telomerase, a cellular reverse transcriptase, is a ribonucleoprotein enzyme that catalyzes the synthesis and extension of telomeric DNA. It is composed of at least, a template RNA component (hTR; human Telomerase RNA) and a catalytic subunit, the telomerase reverse transcriptase (hTERT). The absence of telomerase is associated with telomere shortening and aging of somatic cells, while high telomerase activity is observed in over 85% of human cancer cells, strongly indicating its key role during tumorigenesis. Several details regarding telomere structure and telomerase regulation have already been elucidated, providing new targets for therapeutic exploitation. Further support for anti-telomerase approaches comes from recent studies indicating that telomerase is endowed of additional functions in the control of growth and survival of tumor cells that do not depend only on the ability of this enzyme to maintain telomere length. This observation suggests that inhibiting telomerase or its synthesis may have additional anti-proliferative and apoptosis inducing effect, independently of the reduction of telomere length during cell divisions. This article reviews the basic information about the biology of telomeres and telomerase and attempts to present various approaches that are currently under investigation to inhibit its expression and its activity. We summarize herein distinct anti-telomerase approaches like antisense strategies, reverse transcriptase inhibitors, and G-quadruplex interacting agents, and also review molecules targeting hTERT expression, such as retinoids and evaluate them for their therapeutic potential. "They conceive a certain theory, and everything has to fit into that theory. If one little fact will not fit it, they throw it aside. But it is always the facts that will not fit in that are significant". "Death on the Nile". Agatha Christie.

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Mapping of the Gene for the Mouse Telomerase RNA Component,Terc,to Chromosome 3 by Fluorescencein SituHybridization and Mouse Chromosome Painting

Cited by 18 publications

References 6 publications

3q26‐29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes

3q26‐29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes

Chromosomal Aberrations in Squamous Cell Carcinoma and Solar Keratoses Revealed by Comparative Genomic Hybridization

Telomeres and Telomerase: Pharmacological Targets for New Anticancer Strategies?

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