Much valuable information is obtained from water quality measurements and monitoring of lakes around the world. A powerful tool is the use of mapping techniques, as it offers potential use in water quality research. Both remote sensing techniques and traditional water quality monitoring are required to collect data at sampling stations. This study suggests another approach to determine the most appropriate distribution of sampling stations in water reservoirs that will be mapped for water quality parameters. Tests were conducted for the proposed approach for Secchi disc depth (SDD), chlorophyll-a, turbidity and suspended solids parameters in Lake Beysehir, Turkey. Results of analysis are available for a total of 30 sampling stations in August 2006. Ten sampling stations were used to model Lake Beysehir while the others were used for validation of the model. Sampling stations that offered the best representation of the lake for each parameter were determined. Then, the best representative sampling stations for all parameters in the study were determined. Moreover, in order to confirm the accuracy of these re-determined sampling stations, modelling was performed on the results of the analysis of June 2006, and it was found that the values obtained from the re-determined sampling stations were acceptable.