Mapping of zones of altered morphology and chorionic connective tissue cellular phenotype in human fetal membranes (amniochorion and decidua) overlying the lower uterine pole and cervix before labor at term

McParland, Penny; Taylor, David; Bell, Steven

doi:10.1067/s0002-9378(03)00585-4

Cited by 63 publications

(45 citation statements)

References 13 publications

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“…This distinct para-cervical region has been demonstrated in the FM from both term vaginal and caesarean section deliveries without labor and comprises approximately 2-10% of the total FM surface area (McLaren et al, 1999a;McParland et al, 2003). Bell's group further characterized this area of FM as having increased matrix metalloproteinase (MMP) -9, increased trophoblast apoptosis, differences in the thickness of membrane sub layers, and increased myofibroblasts in this area (McLaren et al, 1999b(McLaren et al, , 2000a(McLaren et al, , 2000bMcParland et al, 2003). Lappas and colleagues have confirmed an increase in apoptotic markers, and have reported increased NF-kB activity and acetylated-forkhead box O1 protein expression in the para-cervical FM region (Reti et al, 2007;Lappas et al, 2009).…”

Section: Term Fm Develops a Para-cervical "Weak Zone" Where Rupture Imentioning

confidence: 99%

“…Malak and Bell first identified an area of socalled "high morphological change" in the zone of FM overlying the cervix (Malak & Bell, 1994). This distinct para-cervical region has been demonstrated in the FM from both term vaginal and caesarean section deliveries without labor and comprises approximately 2-10% of the total FM surface area (McLaren et al, 1999a;McParland et al, 2003). Bell's group further characterized this area of FM as having increased matrix metalloproteinase (MMP) -9, increased trophoblast apoptosis, differences in the thickness of membrane sub layers, and increased myofibroblasts in this area (McLaren et al, 1999b(McLaren et al, , 2000a(McLaren et al, , 2000bMcParland et al, 2003).…”

Section: Term Fm Develops a Para-cervical "Weak Zone" Where Rupture Imentioning

confidence: 99%

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Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

Rangaswamy¹,

Kumar²,

Moore³

et al. 2012

Preterm Birth - Mother and Child

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Section: Term Fm Develops a Para-cervical "Weak Zone" Where Rupture Imentioning

confidence: 99%

Section: Term Fm Develops a Para-cervical "Weak Zone" Where Rupture Imentioning

confidence: 99%

Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

Rangaswamy¹,

Kumar²,

Moore³

et al. 2012

Preterm Birth - Mother and Child

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“…The amnion is the inner layer of the FM facing the amniotic liquid. This thin membrane has a mean thickness of about 60-120 µm [5,6,7,8] and is composed of a monolayer of epithelial cells, a compact layer of collagen and a layer of collagen fibers containing fibroblast cells [4]. The amnion is considered to be the load-bearing layer of the FM [9] becoming the focus of mechanical investigations.…”

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confidence: 99%

Time-dependent mechanical behavior of human amnion: Macroscopic and microscopic characterization

et al. 2015

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Edoardo (2015) Time-dependent mechanical behavior of human amnion: Macroscopic and microscopic characterization. Acta Biomaterialia, 11 . pp. 314-323. ISSN 1878-7568 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/45411/1/mauri_actabiomaterialia2014_preprint.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. AbstractCharacterizing the mechanical response of the human amnion is essential to understand and to eventually prevent premature rupture of fetal membranes. In this study, a large set of macroscopic and microscopic mechanical tests has been carried out on fresh unfixed amnion to gain insight into the time-dependent material response and the underlying mechanisms. Creep and relaxation responses of amnion were characterized in macroscopic uniaxial tension, biaxial tension and inflation configurations. For the first time, these experiments were complemented by microstructural information from nonlinear laser scanning microscopy performed during in-situ uniaxial relaxation tests. The amnion showed large tension reduction during relaxation and small inelastic strain accumulation in creep. The short-term relaxation response was related to a concomitant in-plane and out-of-plane contraction and was dependent on the testing configuration. The microscopic 2 investigation revealed a large volume reduction at the beginning, but no change of volume was measured long-term during relaxation. Tension-strain curves normalized with respect to the maximum strain were highly repeatable in all configurations and allowed the quantification of corresponding characteristic parameters. The present data indicate that dissipative behavior of human amnion is related to two mechanisms: (i) volume reduction due to water outflow (up to ~20 seconds) and (ii) long-term dissipative behavior without macroscopic deformation and no systematic global reorientation of collagen fibers. IntroductionThe fetal membrane (FM) surrounds the growing fetus and ensures its environment during gestation. Preterm premature rupture of the membrane affects about 3% of all pregnancies and increases the risk of morbidity in the newborn [1]. The etiology of preterm premature rupture of the membrane is complex and not completely understood. Repeated mechanical loading, such as that occurring as a result of fetal movement and labor, was recen...

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“…It is considered rather as a biologically programmed process of the histological remodeling leading to membrane weakening [2]. Studies conducted by different authors led to the conclusion that the amniotic membrane is not a homogenous tissue and that at least two different areas of the amnion: placental and cervical (apical), can be distinguished [3,4]. The placental region, the area distant from the uterine cervix, that covers the placenta, is the thickest part of the amnion, particularly resistant to stretch forces.…”

Section: Introductionmentioning

confidence: 99%

The MMP-9/TIMP-1 imbalance and the reduced level of TGF-β in the cervical area of amniotic membrane is a possible risk factor of PROM and premature labor — proof-of-concept study

et al. 2017

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Objectives:To assess the level MMP-9, TIMP-1 and TGF-β in placental and cervical region of amniotic membranes derived from at-term, pre-term and PROM deliveries.Material and methods: 14 amniotic membranes have been assessed; the quantitative analysis of MMP-9, TGF-β and TIMP-1 was assayed using respective Quantikine Immunoassay Kit. Results:The MMP-9 level in PROM samples was similar to the level of MMP-9 in at-term membranes and comparable between the cervical and placental region of these membranes. The concentration of TGF-β and TIMP-1 was decreased in the cervical area of AM derived from deliveries complicated with PROM. Conclusion:The MMP9/TIMP-1 imbalance, as well as the reduced level of TGF-β may be possible risk factors of pre-term labor and PROM.

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Mapping of zones of altered morphology and chorionic connective tissue cellular phenotype in human fetal membranes (amniochorion and decidua) overlying the lower uterine pole and cervix before labor at term

Cited by 63 publications

References 13 publications

Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

Time-dependent mechanical behavior of human amnion: Macroscopic and microscopic characterization

The MMP-9/TIMP-1 imbalance and the reduced level of TGF-β in the cervical area of amniotic membrane is a possible risk factor of PROM and premature labor — proof-of-concept study

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