Woody alien plant species have been deliberately introduced globally in many arid and semi-arid regions, as they can provide services and goods to the rural poor. However, some of these alien trees and shrubs have become invasive over time, with important impacts on biodiversity, ecosystem services, and human well-being. Prosopis was introduced in Baringo County, Kenya, in the 1980s, but since then, it has spread rapidly from the original plantations to new areas. To assess land-use and land-cover (LULC) changes and dynamics in Baringo, we used a combination of dry and wet season Landsat satellite data acquired over a seven-year time interval between 1988-2016, and performed a supervised Random Forest classification. For each time interval, we calculated the extent of Prosopis invasion, rates of spread, gains and losses of specific LULC classes, and the relative importance of Prosopis invasion on LULC changes. The overall accuracy and kappa coefficients of the LULC classifications ranged between 98.1-98.5% and 0.93-0.96, respectively. We found that Prosopis coverage increased from 882 ha in 1988 to 18,792 ha in 2016. The highest negative changes in LULC classes were found for grasslands (−6252 ha; −86%), irrigated cropland (−849 ha; −57%), Vachellia tortilis-dominated vegetation (−3602 ha; −42%), and rainfed cropland (−1432 ha; −37%). Prosopis invasion alone directly accounted for over 30% of these negative changes, suggesting that Prosopis invasion is a key driver of the observed LULC changes in Baringo County. Although the management of Prosopis by utilization has been promoted in Baringo for 10-15 years, the spread of Prosopis has not stopped or slowed down. This suggests that Prosopis management in Baringo and other invaded areas in East Africa needs to be based on a more integrated approach. ecosystems and human welfare [1,2]. These species are a major threat to the environment, because they can: (1) suppress or replace native biodiversity, (2) alter ecosystem functions and services, and (3) cause significant economic damage, costing economies millions of dollars [3].African arid and semi-arid lands (ASALs) were severely degraded by the prolonged Sahelian drought of the 1970s [4][5][6], which prompted the prioritization of tree planting. In Kenya, species from the South and Central American genus Prosopis were selected for screening because they had shown potential in the rehabilitation of quarries [7,8]. Prosopis spp., also known as Mesquite and locally as 'Mathenge' or 'Promi', are perennial, multi-stemmed shrubby or single-canopy trees [9] which are nitrogen-fixing and tolerant to arid conditions [10]. In the 1980s, Prosopis juliflora (Sw.) DC., Prosopis pallida (Willd.), and Prosopis chilensis (Molina) Stuntz were planted in Baringo County [11]. The planted Prosopis trees were initially appreciated due to their ability to grow in degraded and barren landscapes where native vegetation could not grow, thus reducing soil erosion and dust storms, while providing shade and pods that served as fodder for lives...