Mapping protein–protein interactions by mass spectrometry
Xiaonan Liu,
Lawrence Abad,
Lopamudra Chatterjee
et al.
Abstract:Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious diseases. Recent advances in mass spectrometry (MS)‐based protein interactomics have significantly expanded our understanding of the PPIs in cells, with techniques that conti… Show more
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