Mapping QTLs on chicken chromosome 1 for performance and carcass traits in a broiler x layer cross

Nones, Kátia; Ledur, Mônica Corrêa; Ruy, Deborah Clea; Baron, Erica Elias; Melo, Cláudio; Moura, Ana Silvia Alves Meira Tavares; Zanella, Eraldo Lourenso; Burt, David W.; Coutinho, Luiz Lehmann

doi:10.1111/j.1365-2052.2005.01387.x

Cited by 82 publications

(111 citation statements)

References 23 publications

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“…They found that a significant QTL controlling abdominal fat rate at 70 d of age was located at 241 cM (MCW0058-MCW0101), and a suggestive QTL for abdominal fat weight at 70 d of age was located at 214 cM (LE10174-ADL0361) [10]. Nones et al [15] also reported a QTL for abdominal fat weight located on GGA1 at 194 cM (ADL0020-LEI0160). In the present study, we identified four QTL for fat traits, a significant QTL at a 1% genome-wise level for abdominal fat weight, two significant QTL at a 5% genome-wise level for abdominal fat rate and fat width, and a suggestive QTL for fat thickness under the skin.…”

Section: Discussionmentioning

confidence: 90%

SNP mapping of QTL affecting growth and fatness on chicken GGA1

et al. 2007

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-An F2 chicken population was established from a crossbreeding between a Xinghua line and a White Recessive Rock line. A total of 502 F2 chickens in 17 full-sib families from six hatches was obtained, and phenotypic data of 488 individuals were available for analysis. A total of 46 SNP on GGA1 was initially selected based on the average physical distance using the dbSNP database of NCBI. After the polymorphism levels in all F0 individuals (26 individuals) and part of the F1 individuals (22 individuals) were verified, 30 informative SNP were potentially available to genotype all F2 individuals. The linkage map was constructed using Cri-Map. Interval mapping QTL analyses were carried out. QTL for body weight (BW) of 35 d and 42 d, 49 d and 70 d were identified on GGA1 at 351-353 cM and 360 cM, respectively. QTL for abdominal fat weight was on GGA1 at 205 cM, and for abdominal fat rate at 221 cM. Two novel QTL for fat thickness under skin and fat width were detected at 265 cM and 72 cM, respectively. QTL / chicken / growth / fatness / single nucleotide polymorphisms

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Section: Discussionmentioning

confidence: 90%

SNP mapping of QTL affecting growth and fatness on chicken GGA1

et al. 2007

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“…Some QTLs mapped in this population have been described by Nones et al (2006), Ambo et al (2009) and Campos et al (2009). Procedures seeking to reduce the occurrence of false positives or negatives were not employed in these studies, except of course to adjust the level of type I error to an acceptable level.…”

Section: Introductionmentioning

confidence: 99%

Mapping quantitative trait loci in Gallus gallus using principal components

Pinto¹,

Packer²,

Ledur

et al. 2010

R. Bras. Zootec.

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-This study aimed at mapping QTL (quantitative trait loci) using linear combinations of characteristics of economical interest in Gallus gallus. A total of 350 F2 chickens from an initial crossing among males from a broiler line (TT) with females from a layer line (CC) were used. It was conducted a QTL mapping in chromosomes of Gallus gallus (GGA1, GGA3, GGA5, GGA8, GGA11, and GGA13) for 20 performance and carcass traits. For detecting QTL, it was used the likelihood ratio test between a reduced model (including fixed effects of sex, hatch and random effect of infinitesimal genetic value) and a full model (including all the previous effects plus QTL effects). When original characterists were analyzed, that is, before the formation of linear combinations, six significant QTLs were mapped at 1% in the genome, four in the GGA1 (live weight at 35 days of age and at 42 days of age, abdominal fat and heart weight); and two on GGA3 (live weight at 35 and 42 days of age); three significant QTLs at 5% in the genome, one on GGA1 (head weight), one on GGA3 (wings weight), and one on GGA8 (gizzard weight); besides seven suggestive linkages for several traits. When QTLs were mapped for principal components, many mapped QTLs were confirmed for original traits, in addition to finding three QTLs and eight suggestive linkages not mapped for the original traits. cromossomos Gallus gallus (GGA1, GGA3, GGA5, GGA8, GGA11 e GGA13), para 20 características de desempenho e de carcaça. Para detectar QTL foi utilizado o teste da razão de verossimilhanças entre um modelo reduzido (incluindo efeitos fixos de sexo, incubação e o efeito aleatório de valor genético infinitesimal) e um completo (incluindo todos os efeitos anteriores mais os efeitos de QTL). Ao analisar as características originais, ou seja, antes da formação das combinações lineares, foram mapeados seis QTLs significativos a 1% no genoma, quatro no GGA1 (peso vivo aos 35 dias, peso vivo aos 42 dias, gordura abdominal e peso do coração) e dois no GGA3 (peso vivo aos 35 e aos 42 dias de idade); três QTLs significativos a 5% no genoma, sendo um no GGA1 (peso da cabeça), um no GGA3 (peso das asas), e um no GGA8 (peso da moela); além de sete ligações sugestivas para diversas características. Ao mapear QTLs para os componentes principais, foram confirmados vários QTLs mapeados para as características originais, além de encontrar três QTLs e oito ligações sugestivas não mapeadas para as características originais.Palavras-chave: frangos, galinha, genoma, variáveis canônicas Revista Brasileira de Zootecnia

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“…Both pure lines were developed by the Embrapa Swine and Poultry Research Centre and were under multitrait selection for six (TT) and eight (CC) generations when the F2 population was created (details are in Nones et al 2006). A total of 2,063 F2 chickens were obtained from 17 hatches during 8 months, from 21 full-sib families.…”

Section: Population and Traitsmentioning

confidence: 99%

“…A total of 2,063 F2 chickens were obtained from 17 hatches during 8 months, from 21 full-sib families. Seven of these families (652 F2 chickens) were used in the QTL mapping study (Nones et al 2006). …”

Section: Population and Traitsmentioning

confidence: 99%

“…In a Brazilian F2 chicken resource population, Nones et al (2006) mapped quantitative trait loci (QTL) for growth, carcass and fatness traits in a specific region (between markers ADL0234 and LEI0071) of chicken chromosome 1 (GGA1). QTL for growth and fat deposition were also mapped in other populations in the same region (Abasht et al 2006;Liu et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

et al. 2012

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Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F2 chickens from a resource population. In the IGF1 gene, 17SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G>A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c.34208C>T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p=0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p<0.0001) with abdominal fat was observed, and also associations with body weight, feed intake, percentages of carcass, drums and thighs, gizzard and haematocrit. Our findings suggest that the KDM5A gene might play an important role in the abdominal fat deposition in chickens. The IGF1 and KDM5A genes are strong candidates to explain the QTL mapped in this region of GGA1.

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Mapping QTLs on chicken chromosome 1 for performance and carcass traits in a broiler x layer cross

Cited by 82 publications

References 23 publications

SNP mapping of QTL affecting growth and fatness on chicken GGA1

SNP mapping of QTL affecting growth and fatness on chicken GGA1

Mapping quantitative trait loci in Gallus gallus using principal components

Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

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